Search Results - "Yang, Guizhi"

Sphingosine kinase 1 promotes liver fibrosis by preventing miR‐19b‐3p‐mediated inhibition of CCR2 by Lan, Tian, Li, Changzheng, Yang, Guizhi, Sun, Yue, Zhuang, Lihang, Ou, Yitao, Li, Hui, Wang, Genshu, Kisseleva, Tatiana, Brenner, David, Guo, Jiao

“…Chronic liver disease mediated by activation of hepatic stellate cells (HSCs) and Kupffer cells (KCs) leads to liver fibrosis. Here, we aimed to investigate…”
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The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival by Wang, Haizhen, Nicolay, Brandon N., Chick, Joel M., Gao, Xueliang, Geng, Yan, Ren, Hong, Gao, Hui, Yang, Guizhi, Williams, Juliet A., Suski, Jan M., Keibler, Mark A., Sicinska, Ewa, Gerdemann, Ulrike, Haining, W. Nicholas, Roberts, Thomas M., Polyak, Kornelia, Gygi, Steven P., Dyson, Nicholas J., Sicinski, Piotr

“…The cyclin D3–CDK6 kinase complex, which is overactive in some cancers, inhibits two key glycolysis enzymes and thereby enhances the levels of antioxidants in…”
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NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice by Liang, Shuang, Ma, Hsiao-Yen, Zhong, Zhenyu, Dhar, Debanjan, Liu, Xiao, Xu, Jun, Koyama, Yukinori, Nishio, Takahiro, Karin, Daniel, Karin, Gabriel, Mccubbin, Ryan, Zhang, Cuili, Hu, Ronglin, Yang, Guizhi, Chen, Li, Ganguly, Souradipta, Lan, Tian, Karin, Michael, Kisseleva, Tatiana, Brenner, David A.

“…Although there are associations among oxidative stress, reduced nicotinamide adenine dinucleotide phosphate oxidase (NOX) activation, and hepatocellular…”
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Tetrahydropalmatine attenuates liver fibrosis by suppressing endoplasmic reticulum stress in hepatic stellate cells by Xuan, Yuanyuan, Chen, Shiyun, Ding, Xin, Wang, Lexun, Li, Shengwen, Yang, Guizhi, Lan, Tian

“…Quantitative real-time PCR (qPCR) assays showed that hepatic mRNA levels of profibrotic genes, such as α-SMA, Collagen I, platelet-derived growth factor,…”
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Polydatin attenuates hepatic stellate cell proliferation and liver fibrosis by suppressing sphingosine kinase 1 by Lan, Tian, Zhuang, Lihang, Li, Shengwen, Yang, Guizhi, Xuan, Yuanyuan, Guo, Jiao

“…[Display omitted] •Polydatin evidently attenuated liver injury and collagen deposition in mice induced by CCl4.•Polydatin exhibited significant…”
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Single-vector inducible lentiviral RNAi system for oncology target validation by Wiederschain, Dmitri, Susan, Wee, Chen, Lin, Loo, Alice, Yang, Guizhi, Huang, Alan, Chen, Yan, Caponigro, Giordano, Yao, Yung-mae, Lengauer, Christoph, Sellers, William R., Benson, John D.

“…The use of RNA interference (RNAi) has enabled loss-of-function studies in mammalian cancer cells and has hence become critical for  identifying and validating…”
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Osteopontin promotes collagen I synthesis in hepatic stellate cells by miRNA-129-5p inhibition by Chen, Yinghua, Ou, Yitao, Dong, Jiale, Yang, Guizhi, Zeng, Zhi, Liu, Ying, Liu, Bing, Li, Weidong, He, Xiaoshun, Lan, Tian

“…Activation of hepatic stellate cells (HSCs) is an essential event in the initiation and progression of liver fibrosis. HSCs are believed to be the major source…”
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Research on High Precision Tracking Method of Guided Transport Vehicle Based on Autonomous Combination Positioning by Cao, Yuan, Zhang, Shuangshuang, Yang, Guizhi, Wen, Tao

“…Guided transport vehicle (GTV) uses satellite positioning technology, lidar, and high performance video sensors to achieve real‐time positioning and tracing,…”
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Hyperglycemia Induced by Chronic Restraint Stress in Mice Is Associated With Nucleus Tractus Solitarius Injury and Not Just the Direct Effect of Glucocorticoids by Zheng, Xiang, Bi, Wenjie, Yang, Guizhi, Zhao, Jia, Wang, Jie, Li, Xiaojing, Zhou, Xue

“…Chronic restraint stress (CRS) can affect hypothalamic-pituitary-adrenal (HPA) axis activity and increase glucocorticoid levels. Glucocorticoids are stress…”
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Identification of Mixed Lineage Leukemia 1(MLL1) Protein as a Coactivator of Heat Shock Factor 1(HSF1) Protein in Response to Heat Shock Protein 90 (HSP90) Inhibition by Chen, Yaoyu, Chen, Jinyun, Yu, Jianjun, Yang, Guizhi, Temple, Emilia, Harbinski, Fred, Gao, Hui, Wilson, Christopher, Pagliarini, Raymond, Zhou, Wenlai

“…Heat shock protein 90 (HSP90) inhibition inhibits cancer cell proliferation through depleting client oncoproteins and shutting down multiple oncogenic…”
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Protective effects of Longhu Rendan on chronic liver injury and fibrosis in mice by Yang, Guizhi, Li, Shengwen, Jin, Jiahua, Xuan, Yuanyuan, Ding, Liqin, Huang, Minxia, Liu, Jun, Wang, Biye, Lan, Tian

“…Background and aim: Liver fibrosis resulting from persistent liver injury represents a major healthcare problem globally. Traditional Chinese medicine has…”
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Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth by Chen, Jinyun, Chung, Franklin, Yang, Guizhi, Pu, Minying, Gao, Hui, Jiang, Wei, Yin, Hong, Capka, Vladimir, Kasibhatla, Shailaja, Laffitte, Bryan, Jaeger, Savina, Pagliarini, Raymond, Chen, Yaoyu, Zhou, Wenlai

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A hierarchical connectionist CPG controller for controlling the snake-like robot's 3-dimensional gaits by Guizhi Yang, Shugen Ma, Bin Li, Minghui Wang

“…Connectionist Central Pattern Generator models (CCPG) are helpful to understand how the CPG neural mechanism functions, and have relatively small complexity…”
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Strath terraces of Jinshaan Canyon, Yellow River, and Quaternary tectonic movements of the Ordos Plateau, North China by Cheng, Shaoping, Deng, Qidong, Zhou, Shiwei, Yang, Guizhi

“…ABSTRACT Studies of the strath terraces in Jinshaan Canyon − where the Yellow River cuts through the Ordos Plateau in the continental interior of China −…”
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Cordycepin Ameliorates Nonalcoholic Steatohepatitis by Activation of the AMP‐Activated Protein Kinase Signaling Pathway by Lan, Tian, Yu, Yang, Zhang, Jing, Li, Haonan, Weng, Qiqing, Jiang, Shuo, Tian, Song, Xu, Tonghao, Hu, Sha, Yang, Guizhi, Zhang, Yan, Wang, Weixuan, Wang, Lexun, Zhu, Qing, Rong, Xianglu, Guo, Jiao

“…Background and Aims Nonalcoholic fatty liver disease, especially nonalcoholic steatohepatitis (NASH), has become a major cause of liver transplantation and…”
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Improved electrical properties of detector-grade Cd 1−x Zn x Te single crystals passivated by KMnO4 and K2S2O8 solutions by Yu, Pengfei, Yang, Guizhi, Sun, Xing, Rao, Tianjing, Fu, Haijia, Luan, Lijun, Li, Hui

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Improved electrical properties of detector-grade Cd1−xZnxTe single crystals passivated by KMnO4 and K2S2O8 solutions by Yu, Pengfei, Yang, Guizhi, Sun, Xing, Rao, Tianjing, Fu, Haijia, Luan, Lijun, Li, Hui

“…Surface treatment is very important for detector-grade Cd1−xZnxTe crystals. In this paper, electrical properties of detector-grade Cd1−xZnxTe single crystals…”
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Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling by Liu, Chen, Lu, Hengyu, Wang, Hongyun, Loo, Alice, Zhang, Xiamei, Yang, Guizhi, Kowal, Colleen, Delach, Scott, Wang, Ye, Goldoni, Silvia, Hastings, William D, Wong, Karrie, Gao, Hui, Meyer, Matthew J, Moody, Susan E, LaMarche, Matthew J, Engelman, Jeffrey A, Williams, Juliet A, Hammerman, Peter S, Abrams, Tinya J, Mohseni, Morvarid, Caponigro, Giordano, Hao, Huai-Xiang

“…SHP2 inhibitors offer an appealing and novel approach to inhibit receptor tyrosine kinase (RTK) signaling, which is the oncogenic driver in many tumors or is…”
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H2/CO production via high temperature electrolysis of H2O/CO2 coupling with solar spectral splitting at a tunable cut-off wavelength by Yang, Weixu, Pan, Heng, Yang, Guizhi, Han, Fengshuang, Dang, Zhi-Min, Lu, Youjun, Shao, Zongping, Zhu, Liya

“…Solar driven CO2/H2O splitting is a promising path for large-scale and long-term solar energy conversion and storage. In this work, a thermodynamic model of…”
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High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response by Gao, Hui, Korn, Joshua M, Ferretti, Stéphane, Monahan, John E, Wang, Youzhen, Singh, Mallika, Zhang, Chao, Schnell, Christian, Yang, Guizhi, Zhang, Yun, Balbin, O Alejandro, Barbe, Stéphanie, Cai, Hongbo, Casey, Fergal, Chatterjee, Susmita, Chiang, Derek Y, Chuai, Shannon, Cogan, Shawn M, Collins, Scott D, Dammassa, Ernesta, Ebel, Nicolas, Embry, Millicent, Green, John, Kauffmann, Audrey, Kowal, Colleen, Leary, Rebecca J, Lehar, Joseph, Liang, Ying, Loo, Alice, Lorenzana, Edward, Robert McDonald, E, McLaughlin, Margaret E, Merkin, Jason, Meyer, Ronald, Naylor, Tara L, Patawaran, Montesa, Reddy, Anupama, Röelli, Claudia, Ruddy, David A, Salangsang, Fernando, Santacroce, Francesca, Singh, Angad P, Tang, Yan, Tinetto, Walter, Tobler, Sonja, Velazquez, Roberto, Venkatesan, Kavitha, Von Arx, Fabian, Wang, Hui Qin, Wang, Zongyao, Wiesmann, Marion, Wyss, Daniel, Xu, Fiona, Bitter, Hans, Atadja, Peter, Lees, Emma, Hofmann, Francesco, Li, En, Keen, Nicholas, Cozens, Robert, Jensen, Michael Rugaard, Pryer, Nancy K, Williams, Juliet A, Sellers, William R

“…The authors implement a collection of patient-derived xenograft tumors to test cancer drug responses. Profiling candidate therapeutics with limited cancer…”
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