Search Results - "Yang, David C. H."

Identification and Biochemical Characterization of Small-Molecule Inhibitors of Clostridium botulinum Neurotoxin Serotype A by Roxas-Duncan, Virginia, Enyedy, Istvan, Montgomery, Vicki A, Eccard, Vanessa S, Carrington, Marco A, Lai, Huiguo, Gul, Nizamettin, Yang, David C H, Smith, Leonard A

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Two Protein Lysine Methyltransferases Methylate Outer Membrane Protein B from Rickettsia by Abeykoon, Amila H, Chao, Chien-Chung, Wang, Guanghui, Gucek, Marjan, Yang, David C. H, Ching, Wei-Mei

“…Rickettsia prowazekii, the etiologic agent of epidemic typhus, is a potential biological threat agent. Its outer membrane protein B (OmpB) is an immunodominant…”
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Expression of SUMO-2/3 Induced Senescence through p53- and pRB-mediated Pathways by Li, Tianwei, Santockyte, Rasa, Shen, Rong-Fong, Tekle, Ephrem, Wang, Guanghui, Yang, David C.H., Chock, P. Boon

“…Three highly homologous small ubiquitin-related modifier (SUMO) proteins have been identified in mammals. Modifications of proteins by SUMO-1 have been shown…”
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Sumoylation of Heterogeneous Nuclear Ribonucleoproteins, Zinc Finger Proteins, and Nuclear Pore Complex Proteins: A Proteomic Analysis by Li, Tianwei, Evdokimov, Evgenij, Shen, Rong-Fong, Chao, Chien-Chung, Tekle, Ephrem, Wang, Tao, Stadtman, Earl R., David C. H. Yang, Chock, P. Boon

“…SUMO, a small ubiquitin-related modifier, is known to covalently attach to a number of nuclear regulatory proteins such as p53, IκB, promyelocytic leukemia…”
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FAT10 modifies p53 and upregulates its transcriptional activity by Li, Tianwei, Santockyte, Rasa, Yu, Shiqin, Shen, Rong-Fong, Tekle, Ephrem, Lee, Caroline G.L., Yang, David C.H., Chock, P. Boon

“…► Our study reveals that p53 is covalently modified by FAT10. ► Overexpression of FAT10 in HEK293 cells leads to elevation of p53 transcriptional activity. ►…”
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Cancer Preventive Isothiocyanates Induce Selective Degradation of Cellular α- and β-Tubulins by Proteasomes by Mi, Lixin, Gan, Nanqin, Cheema, Amrita, Dakshanamurthy, Sivanesan, Wang, Xiantao, Yang, David C.H., Chung, Fung-Lung

“…Although it is conceivable that cancer preventive isothiocyanates (ITCs), a family of compounds in cruciferous vegetables, induce cell cycle arrest and…”
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Outer Membrane Protein OmpB Methylation May Mediate Bacterial Virulence by Yang, David C.H., Abeykoon, Amila H., Choi, Bok-Eum, Ching, Wei-Mei, Chock, P. Boon

“…Methylation of outer membrane proteins (OMPs) has been implicated in bacterial virulence. Lysine methylation in rickettsial OmpB is correlated with rickettsial…”
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Systematic analysis of fusion and affinity tags using human aspartyl-tRNA synthetase expressed in E. coli by Guzzo, Catherine M., Yang, David C.H.

“…Fusion and affinity tags are popular tools for the expression of mammalian proteins in bacteria. To facilitate the selection of expression approaches, a…”
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Structural Insights into Substrate Recognition and Catalysis in Outer Membrane Protein B (OmpB) by Protein-lysine Methyltransferases from Rickettsia by Abeykoon, Amila H., Noinaj, Nicholas, Choi, Bok-Eum, Wise, Lindsay, He, Yi, Chao, Chien-Chung, Wang, Guanghui, Gucek, Marjan, Ching, Wei-Mei, Chock, P. Boon, Buchanan, Susan K., Yang, David C.H.

“…Rickettsia belong to a family of Gram-negative obligate intracellular infectious bacteria that are the causative agents of typhus and spotted fever. Outer…”
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Multimethylation of Rickettsia OmpB Catalyzed by Lysine Methyltransferases by Abeykoon, Amila, Wang, Guanghui, Chao, Chien-Chung, Chock, P. Boon, Gucek, Marjan, Ching, Wei-Mei, Yang, David C.H.

“…Methylation of rickettsial OmpB (outer membrane protein B) has been implicated in bacterial virulence. Rickettsial methyltransferases RP789 and RP027-028 are…”
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Quinolinol and peptide inhibitors of zinc protease in botulinum neurotoxin A: Effects of zinc ion and peptides on inhibition by Lai, Huiguo, Feng, Minghao, Roxas-Duncan, Virginia, Dakshanamurthy, Sivanesan, Smith, Leonard A., Yang, David C.H.

“…Quinolinol derivatives were found to be effective inhibitors of botulinum neurotoxin serotype A (BoNT/A). Studies of the inhibition and binding of…”
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Polyubiquitylation of PARP-1 through ubiquitin K48 is modulated by activated DNA, NAD+, and dipeptides by Wang, Tao, Simbulan-Rosenthal, Cynthia M., Smulson, Mark E., Chock, P. Boon, Yang, David C.H.

“…Poly(ADP‐ribose) polymerase‐1 (PARP‐1) is the most abundant and the best‐studied isoform of a family of enzymes that catalyze the polymerization of ADP‐ribose…”
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A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers by Li, Tianwei, Santockyte, Rasa, Shen, Rong-Fong, Tekle, Ephrem, Wang, Guanghui, Yang, David C.H., Chock, P. Boon

“…Ubiquitin-like modifiers (UBLs) contain ubiquitin homology domains and can covalently modify target proteins in a manner similar to ubiquitylation. In this…”
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Structural organization of the multienzyme complex of mammalian aminoacyl-tRNA synthetases by Godar, Dianne E, Godar, Douglas E, Garcia, Victor, Jacobo, Alfredo, Aebi, Ueli, Yang, David C. H

“…The multienzyme complexes of mammalian aminoacyl-tRNA synthetases were purified from rat liver, rabbit liver, and rabbit reticulocytes according to the…”
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Induction of immunomodulator transcriptional responses by cholera toxin by Royaee, Atabak R., Hammamieh, Rasha, Mendis, Chanaka, Das, Rina, Jett, Marti, H. Yang, David C.

“…Cholera toxin (CT) is the causative agent of cholera, binds to GM1 glycosphingolipids, induces the production of cellular cAMP and is also a very powerful…”
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Cholera toxin induced novel genes in human lymphocytes and monocytes by Royaee, Atabak R., Jong, Linda, Mendis, Chanaka, Das, Rina, Jett, Marti, Yang, David C.H.

“…Cholera toxin (CT) is well known as an inducer of the accumulation of cellular cAMP through the ADP-ribosylation of the Gs protein by CT. CT is also one of the…”
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A peptide from the extension of Lys-tRNA synthetase binds to transfer RNA and DNA by Yiadom, Kwabena P.A.B, Hammamieh, Rasha, Ukpabi, Nkoli, Tsang, Pearl, Yang, David C.H

“…Eukaryotic aminoacyl-tRNA synthetases have dispensable extensions appended at the amino- or carboxyl-terminus as compared to their bacterial counterparts…”
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Production of Tumor Necrosis Factor Alpha in Human T Lymphocytes by Staphylococcal Enterotoxin B Correlates with Toxin-Induced Proliferation and Is Regulated through Protein Kinase C by ZHENGYIN YAN, YANG, D. C. H, NEILL, R, JETT, M

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Structural and catalytic roles of conserved cysteine residues in human lysyl‐tRNA synthetase by Maanu, Christiana A Addei, Yang, David C H

“…Abstract only Human and eukaryotic tRNA‐synthetases contain substantially more cysteine residues than their bacterial counterparts, while the other nineteen…”
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Lysyl-tRNA synthetase interacts with EF1α, aspartyl-tRNA synthetase and p38 in vitro by Guzzo, Catherine M., Yang, David C.H.

“…The functions of evolved mammalian supramolecular assemblies and extensions of enzymes are not well understood. Human lysyl-tRNA synthetase (hKRS) only upon…”
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