Search Results - "Yang, Bryant H"

Highly Active Palladium Catalysts for Suzuki Coupling Reactions by Wolfe, John P, Singer, Robert A, Yang, Bryant H, Buchwald, Stephen L

“…Mixtures of palladium acetate and o-(di-tert-butylphosphino)biphenyl (4) catalyze the room-temperature Suzuki coupling of aryl bromides and aryl chlorides with…”
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A Palladium-Catalyzed Method for the Preparation of Indoles via the Fischer Indole Synthesis by Wagaw, Seble, Yang, Bryant H, Buchwald, Stephen L

“…A Pd-catalyzed method for the preparation of N-aryl benzophenone hydrazones 4 is described. The use of a Pd/BINAP-based catalyst provides hydrazones 4 in good…”
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Pseudoephedrine as a Practical Chiral Auxiliary for the Synthesis of Highly Enantiomerically Enriched Carboxylic Acids, Alcohols, Aldehydes, and Ketones by Myers, Andrew G, Yang, Bryant H, Chen, Hou, McKinstry, Lydia, Kopecky, David J, Gleason, James L

“…The use of pseudoephedrine as a practical chiral auxiliary for asymmetric synthesis is described in full. Both enantiomers of pseudoephedrine are inexpensive…”
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The Development of Efficient Protocols for the Palladium-Catalyzed Cyclization Reactions of Secondary Amides and Carbamates by Yang, Bryant H, Buchwald, Stephen L

“…With the proper choice of palladium catalyst, ligand, and base, five-, six-, and seven-membered rings are formed efficiently from secondary amide or secondary…”
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Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation by Reed, Anthony B., Lanman, Brian A., Holder, Jerry Ryan, Yang, Bryant H., Ma, Ji, Humphreys, Sara C., Wang, Zhican, Chan, Joyce C.Y., Miranda, Les P., Swaminath, Gayathri, Allen, John G.

“…[Display omitted] •Lipidated apelin-13 showed in an increase in ejection fraction in an anesthetized rat myocardial infarction model.•Rat plasma protein…”
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Palladium-catalyzed amination of aryl halides and sulfonates by Yang, Bryant H, Buchwald, Stephen L

“…In this review, the progress made in the palladium-catalyzed amination of aryl halides and sulfonates is described with particular attention given to…”
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Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid by Weiss, Matthew M, Williamson, Toni, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dineen, Thomas A, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, Rattan, Claire, San Miguel, Tisha, Sickmier, E.Allen, Wahl, Robert C, Wen, Paul H, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge

“…A series of potent hydroxyethyl amine (HEA) derived inhibitors of β-site APP cleaving enzyme (BACE1) was optimized to address suboptimal pharmacokinetics and…”
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Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors by Dineen, Thomas A, Weiss, Matthew M, Williamson, Toni, Acton, Paul, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dunn, Robert T, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, San Miguel, Tisha, Sickmier, E. Allen, Vargas, Hugo M, Wahl, Robert C, Wen, Paul H, Whittington, Douglas A, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge

“…We have previously shown that hydroxyethylamines can be potent inhibitors of the BACE1 enzyme and that the generation of BACE1 inhibitors with CYP 3A4…”
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Hydroxyethylamine-based inhibitors of BACE1: P1–P3 macrocyclization can improve potency, selectivity, and cell activity by Pennington, Lewis D., Whittington, Douglas A., Bartberger, Michael D., Jordan, Steven R., Monenschein, Holger, Nguyen, Thomas T., Yang, Bryant H., Xue, Qiufen M., Vounatsos, Filisaty, Wahl, Robert C., Chen, Kui, Wood, Stephen, Citron, Martin, Patel, Vinod F., Hitchcock, Stephen A., Zhong, Wenge

“…We describe a systematic study of how macrocyclization in the P1–P3 region of hydroxyethylamine-based inhibitors of β-site amyloid precursor protein…”
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A Palladium-Catalyzed Strategy for the Preparation of Indoles:  A Novel Entry into the Fischer Indole Synthesis by Wagaw, Seble, Yang, Bryant H, Buchwald, Stephen L

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Use of Pseudoephedrine as a Practical Chiral Auxiliary for Asymmetric Synthesis by Myers, Andrew G, Yang, Bryant H, Chen, Hou, Gleason, James L

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Lithium amidotrihydroborate, a powerful new reductant. Transformation of tertiary amides to primary alcohols by Myers, Andrew G., Yang, Bryant H., David, Kopecky J.

“…Lithium amidotrihydroborate (LiH 2NBH 3, LAB) is a new and highly nucleophilic reducing agent that is easily prepared by deprotonation of the commerical…”
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Use of pseudoephedrine as a practical chiral auxiliary for asymmetric synthesis by Yang, Bryant H

“…The use of pseudoephedrine as a practical chiral auxiliary for asymmetric synthesis is described. Both enantiomers of pseudoephedrine are inexpensive commodity…”
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