Search Results - "Yang, Bryant"

Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation by Reed, Anthony B., Lanman, Brian A., Holder, Jerry Ryan, Yang, Bryant H., Ma, Ji, Humphreys, Sara C., Wang, Zhican, Chan, Joyce C.Y., Miranda, Les P., Swaminath, Gayathri, Allen, John G.

“…[Display omitted] •Lipidated apelin-13 showed in an increase in ejection fraction in an anesthetized rat myocardial infarction model.•Rat plasma protein…”
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Highly Active Palladium Catalysts for Suzuki Coupling Reactions by Wolfe, John P, Singer, Robert A, Yang, Bryant H, Buchwald, Stephen L

“…Mixtures of palladium acetate and o-(di-tert-butylphosphino)biphenyl (4) catalyze the room-temperature Suzuki coupling of aryl bromides and aryl chlorides with…”
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Palladium-catalyzed amination of aryl halides and sulfonates by Yang, Bryant H, Buchwald, Stephen L

“…In this review, the progress made in the palladium-catalyzed amination of aryl halides and sulfonates is described with particular attention given to…”
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Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid by Weiss, Matthew M, Williamson, Toni, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dineen, Thomas A, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, Rattan, Claire, San Miguel, Tisha, Sickmier, E.Allen, Wahl, Robert C, Wen, Paul H, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge

“…A series of potent hydroxyethyl amine (HEA) derived inhibitors of β-site APP cleaving enzyme (BACE1) was optimized to address suboptimal pharmacokinetics and…”
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Bacterial coinfections with coronavirus disease 2019 (COVID-19) by Huang, Glen, Furukawa, Daisuke, Yang, Bryant D., Kim, Brian J., Jeng, Arthur C.

“…Abstract Background: The pandemic caused by severe acute respiratory coronavirus virus 2 (SARS-CoV-2) has dramatically increased cheshospitalizations, and it…”
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A Palladium-Catalyzed Method for the Preparation of Indoles via the Fischer Indole Synthesis by Wagaw, Seble, Yang, Bryant H, Buchwald, Stephen L

“…A Pd-catalyzed method for the preparation of N-aryl benzophenone hydrazones 4 is described. The use of a Pd/BINAP-based catalyst provides hydrazones 4 in good…”
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Pseudoephedrine as a Practical Chiral Auxiliary for the Synthesis of Highly Enantiomerically Enriched Carboxylic Acids, Alcohols, Aldehydes, and Ketones by Myers, Andrew G, Yang, Bryant H, Chen, Hou, McKinstry, Lydia, Kopecky, David J, Gleason, James L

“…The use of pseudoephedrine as a practical chiral auxiliary for asymmetric synthesis is described in full. Both enantiomers of pseudoephedrine are inexpensive…”
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The Development of Efficient Protocols for the Palladium-Catalyzed Cyclization Reactions of Secondary Amides and Carbamates by Yang, Bryant H, Buchwald, Stephen L

“…With the proper choice of palladium catalyst, ligand, and base, five-, six-, and seven-membered rings are formed efficiently from secondary amide or secondary…”
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Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors by Dineen, Thomas A, Weiss, Matthew M, Williamson, Toni, Acton, Paul, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dunn, Robert T, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, San Miguel, Tisha, Sickmier, E. Allen, Vargas, Hugo M, Wahl, Robert C, Wen, Paul H, Whittington, Douglas A, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge

“…We have previously shown that hydroxyethylamines can be potent inhibitors of the BACE1 enzyme and that the generation of BACE1 inhibitors with CYP 3A4…”
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Hydroxyethylamine-based inhibitors of BACE1: P1–P3 macrocyclization can improve potency, selectivity, and cell activity by Pennington, Lewis D., Whittington, Douglas A., Bartberger, Michael D., Jordan, Steven R., Monenschein, Holger, Nguyen, Thomas T., Yang, Bryant H., Xue, Qiufen M., Vounatsos, Filisaty, Wahl, Robert C., Chen, Kui, Wood, Stephen, Citron, Martin, Patel, Vinod F., Hitchcock, Stephen A., Zhong, Wenge

“…We describe a systematic study of how macrocyclization in the P1–P3 region of hydroxyethylamine-based inhibitors of β-site amyloid precursor protein…”
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A Palladium-Catalyzed Strategy for the Preparation of Indoles:  A Novel Entry into the Fischer Indole Synthesis by Wagaw, Seble, Yang, Bryant H, Buchwald, Stephen L

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Use of Pseudoephedrine as a Practical Chiral Auxiliary for Asymmetric Synthesis by Myers, Andrew G, Yang, Bryant H, Chen, Hou, Gleason, James L

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Clinical Characteristics and Outcomes of Coronavirus Disease 2019 Patients Who Received Compassionate-Use Leronlimab by Yang, Bryant, Fulcher, Jennifer A, Ahn, Jenny, Berro, Marlene, Goodman-Meza, David, Dhody, Kush, Sacha, Jonah B, Naeim, Arash, Yang, Otto O

“…Abstract Background Leronlimab, a monoclonal antibody blocker of C-C chemokine receptor type 5 originally developed to treat human immunodeficiency virus…”
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Lithium amidotrihydroborate, a powerful new reductant. Transformation of tertiary amides to primary alcohols by Myers, Andrew G., Yang, Bryant H., David, Kopecky J.

“…Lithium amidotrihydroborate (LiH 2NBH 3, LAB) is a new and highly nucleophilic reducing agent that is easily prepared by deprotonation of the commerical…”
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657. Diagnostic Utility of Dedicated Fungal Blood Cultures for Diagnosis of Candidemia by Yang, Bryant, Garner, Omai, Ou, Richard, Stanzione, Nicholas

“…Abstract Background Blood culture techniques have improved to the point where they are considered sensitive enough for detection of Candida. Expert guidelines…”
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Abstract 19511: Progesterone Reduces Isoproterenol-Induced pVTs in Male Transgenic Long QT Syndrome 2 (LQT2) Rabbits by Kossidas, Konstantinos, Zheng, Zhe, Odening, Katja E, Zehender, Manfred, Schoffield, Lorraine, Taylor, Chantel, Yang, Bryant, Pfeiffer, Zachary, Choi, Bum-Rak, Koren, Gideon

“…Abstract only Background: During childhood, boys with long QT syndrome (LQT) have a higher risk than girls for developing ventricular arrhythmia and sudden…”
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Hydroxyethylamine-based inhibitors of BACE1: P1aP3 macrocyclization can improve potency, selectivity, and cell activity by Pennington, Lewis, Whittington, Douglas, Bartberger, Michael, Jordan, Steven, Monenschein, Holger, Nguyen, Thomas, Yang, Bryant, Xue, Qiufen, Vounatsos, Filisaty, Wahl, Robert, Chen, Kui, Wood, Stephen, Citron, Martin, Patel, Vinod, Hitchcock, Stephen, Zhong, Wenge

“…We describe a systematic study of how macrocyclization in the P1aP3 region of hydroxyethylamine-based inhibitors of I2-site amyloid precursor protein…”
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Abstract 349: Functional Scaffold-Free 3D Cardiac Microtissues: A Novel Model for the Investigation of Heart Cells by Desroches, Bethany, Zhang, Peng, Choi, Bum-Rak, King, Michelle E, Maldonado, Angel E, Li, Weiyan, Rago, Adam, Liu, GongXin, Nath, Nandan, Hartmann, Kathryn M, Yang, Bryant, Koren, Gideon, Morgan, Jeffrey, Mende, Ulrike

“…Abstract only To bridge the gap between 2D cell culture and tissue, various 3D cell culture approaches have been developed for the investigation of cardiac…”
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A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase by Kaller, Matthew R, Harried, Scott S, Albrecht, Brian, Amarante, Patricia, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Brown, Ryan, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Graceffa, Russell, Hickman, Dean, Judd, Ted, Kriemen, Chuck, La, Daniel, Li, Vivian, Lopez, Patricia, Luo, Yi, Masse, Craig, Monenschein, Holger, Nguyen, Thomas, Pennington, Lewis D, Miguel, Tisha San, Sickmier, E. Allen, Wahl, Robert C, Weiss, Matthew M, Wen, Paul H, Williamson, Toni, Wood, Stephen, Xue, May, Yang, Bryant, Zhang, Jianhua, Patel, Vinod, Zhong, Wenge, Hitchcock, Stephen

“…β-Secretase inhibitors are potentially disease-modifying treatments for Alzheimer's disease. Previous efforts in our laboratory have resulted in…”
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Discovery of thienopyridines as Src-family selective Lck inhibitors by Abbott, Lily, Betschmann, Patrick, Burchat, Andrew, Calderwood, David J., Davis, Heather, Hrnciar, Peter, Hirst, Gavin C., Li, Biqin, Morytko, Michael, Mullen, Kelly, Yang, Bryant

“…We describe the identification, SAR, and in vivo pharmacology of a new series of Src-family selective Lck inhibitors. These thienopyridines were designed to…”
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