Search Results - "Yang, Benjy Tan Jek"
-
1
Identification and characterization of a novel enhancer in the HTLV-1 proviral genome
Published in Nature communications (03-05-2022)“…Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes adult T-cell leukemia/lymphoma (ATL), a cancer of infected CD4 + T-cells. There is both…”
Get full text
Journal Article -
2
Clonality of HIV-1– and HTLV-1–Infected Cells in Naturally Coinfected Individuals
Published in The Journal of infectious diseases (18-01-2022)“…Abstract Background Coinfection with human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type 1 (HTLV-1) diminishes the value of the…”
Get full text
Journal Article -
3
Two-step evolution of HIV-1 budding system leading to pandemic in the human population
Published in Cell reports (Cambridge) (27-02-2024)“…The pandemic HIV-1, HIV-1 group M, emerged from a single spillover event of its ancestral lentivirus from a chimpanzee. During human-to-human spread worldwide,…”
Get full text
Journal Article -
4
HIV-1 DNA-capture-seq is a useful tool for the comprehensive characterization of HIV-1 provirus
Published in Scientific reports (23-08-2019)“…Regardless of recent advances in the development of anti-retroviral drugs, it is still extremely difficult to eradicate HIV-1 from infected individuals. The…”
Get full text
Journal Article -
5
Clone Dynamics and Its Application for the Diagnosis of Enzootic Bovine Leukosis
Published in Journal of virology (31-01-2023)“…Bovine leukemia virus (BLV) infection results in polyclonal expansion of infected B lymphocytes, and ~5% of infected cattle develop enzootic bovine leukosis…”
Get full text
Journal Article -
6
The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach
Published in Cell reports (Cambridge) (15-10-2019)“…The retrovirus human T-cell leukemia virus type 1 (HTLV-1) integrates into the host DNA, achieves persistent infection, and induces human diseases. Here, we…”
Get full text
Journal Article -
7
Erratum to: Clonality of HIV-1– and HTLV-1–Infected Cells in Naturally Coinfected Individuals
Published in The Journal of infectious diseases (18-01-2022)Get full text
Journal Article -
8
Multiomics Investigation Revealing the Characteristics of HIV-1-Infected Cells In Vivo
Published in Cell reports (Cambridge) (14-07-2020)“…For eradication of HIV-1 infection, it is important to elucidate the detailed features and heterogeneity of HIV-1-infected cells in vivo. To reveal multiple…”
Get full text
Journal Article -
9
Assessing the effects of antiretroviral therapy-latency-reversing agent combination therapy on eradicating replication-competent HIV provirus in a Jurkat cell culture model
Published in STAR protocols (15-12-2023)“…Eradication of HIV-1 latently infected cells is an important issue in HIV treatment. However, there are limited models available to assess therapeutic efficacy…”
Get full text
Journal Article -
10
HIV-Tocky system to visualize proviral expression dynamics
Published in Communications biology (20-03-2024)“…Determinants of HIV-1 latency establishment are yet to be elucidated. HIV reservoir comprises a rare fraction of infected cells that can survive host and…”
Get full text
Journal Article -
11
A widely distributed HIV-1 provirus elimination assay to evaluate latency-reversing agents in vitro
Published in Cell reports methods (20-12-2021)“…Persistence of HIV-1 latent reservoir cells during antiretroviral therapy (ART) is a major obstacle for curing HIV-1. Even though latency-reversing agents…”
Get full text
Journal Article -
12
A micro-disc-based multiplex method for monitoring emerging SARS-CoV-2 variants using the molecular diagnostic tool Intelli-OVI
Published in Communications medicine (09-08-2024)“…Background Highly transmissible viruses including SARS-CoV-2 frequently accumulate novel mutations that are detected via high-throughput sequencing. However,…”
Get full text
Journal Article -
13
Effect of Viral Antigen Mismatch on Antiviral T-Cell Response and Immunotherapeutic Efficacy Against Adult T-Cell Leukemia/Lymphoma
Published in The Journal of infectious diseases (10-10-2024)“…Human T-cell leukemia virus type 1 (HTLV-1) transforms primary CD4 T cells in vitro within a short time; however, majority of infected individuals maintain an…”
Get full text
Journal Article -
14
Viral antigen mismatch affects antiviral T-cell response and may impair immunotherapeutic efficacy against adult T-cell leukemia/lymphoma
Published in The Journal of infectious diseases (20-09-2024)“…HTLV-1 transforms primary CD4+ T cells in vitro within a short time; however, majority of infected individuals maintain an asymptomatic condition, suggesting…”
Get full text
Journal Article -
15
The Presence and Possible Role of Virus-Host Chimeric Transcripts in Adult T-Cell Leukemia-Lymphoma
Published in Blood (13-11-2019)“…The retrovirus human T-cell leukemia virus type 1 (HTLV-1) integrates into the host genome and persists for the lifetime of the host. There are tens of…”
Get full text
Journal Article -
16
Abstract 1621: Integrated analysis of genetic, transcriptional and TME evolution of ccRCC: TRACERx Renal
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Background: Genetic evolution of clear cell renal cell carcinoma (ccRCC) follows distinct trajectories, with varying levels of intratumor heterogeneity (ITH)…”
Get full text
Journal Article -
17
Highly Sensitive Viral RNA-Seq Is a Powerful Tool to Analyze the Viral Transcripts in HTLV-1-Infected Individuals
Published in Blood (08-12-2017)“…Introduction Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus which causes two major pathologies in infected individuals, Adult T-cell…”
Get full text
Journal Article