Search Results - "Yanes, Óscar"

eRah: A Computational Tool Integrating Spectral Deconvolution and Alignment with Quantification and Identification of Metabolites in GC/MS-Based Metabolomics by Domingo-Almenara, Xavier, Brezmes, Jesus, Vinaixa, Maria, Samino, Sara, Ramirez, Noelia, Ramon-Krauel, Marta, Lerin, Carles, Díaz, Marta, Ibáñez, Lourdes, Correig, Xavier, Perera-Lluna, Alexandre, Yanes, Oscar

“…Gas chromatography coupled to mass spectrometry (GC/MS) has been a long-standing approach used for identifying small molecules due to the highly reproducible…”
Get full text

Circulating metabolomic and lipidomic changes in subjects with new-onset type 1 diabetes after optimization of glycemic control by Julve, Josep, Genua, Idoia, Quifer-Rada, Paola, Yanes, Óscar, Barranco-Altirriba, Maria, Hernández, Marta, Junza, Alexandra, Capellades, Jordi, Granado-Casas, Minerva, Alonso, Núria, Castelblanco, Esmeralda, Mauricio, Didac

“…To uncover novel candidate metabolomic and lipidomic biomarkers in newly-diagnosed type 1 diabetes (T1DM) after achieving optimal glucose control…”
Get full text

CD98hc (SLC3A2) sustains amino acid and nucleotide availability for cell cycle progression by Cano-Crespo, Sara, Chillarón, Josep, Junza, Alexandra, Fernández-Miranda, Gonzalo, García, Judit, Polte, Christine, R. de la Ballina, Laura, Ignatova, Zoya, Yanes, Óscar, Zorzano, Antonio, Stephan-Otto Attolini, Camille, Palacín, Manuel

“…CD98 heavy chain (CD98hc) forms heteromeric amino acid (AA) transporters by interacting with different light chains. Cancer cells overexpress…”
Get full text

Null diffusion-based enrichment for metabolomics data by Picart-Armada, Sergio, Fernández-Albert, Francesc, Vinaixa, Maria, Rodríguez, Miguel A, Aivio, Suvi, Stracker, Travis H, Yanes, Oscar, Perera-Lluna, Alexandre

“…Metabolomics experiments identify metabolites whose abundance varies as the conditions under study change. Pathway enrichment tools help in the identification…”
Get full text

Lipoprotein hydrophobic core lipids are partially extruded to surface in smaller HDL: “Herniated” HDL, a common feature in diabetes by Amigó, Núria, Mallol, Roger, Heras, Mercedes, Martínez-Hervás, Sergio, Blanco-Vaca, Francisco, Escolà-Gil, Joan Carles, Plana, Núria, Yanes, Óscar, Masana, Lluís, Correig, Xavier

“…Recent studies have shown that pharmacological increases in HDL cholesterol concentrations do not necessarily translate into clinical benefits for patients,…”
Get full text

Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice by Vinaixa, María, Canelles, Sandra, González-Murillo, África, Ferreira, Vítor, Grajales, Diana, Guerra-Cantera, Santiago, Campillo-Calatayud, Ana, Ramírez-Orellana, Manuel, Yanes, Óscar, Frago, Laura M., Valverde, Ángela M., Barrios, Vicente

“…Insulin receptor substrate (IRS) 2 is a key mediator of insulin signaling and IRS-2 knockout (IRS2−/−) mice are a preclinical model to study the development of…”
Get full text

Epigenetic Regulation at the Interplay Between Gut Microbiota and Host Metabolism by Miro-Blanch, Joan, Yanes, Oscar

“…Gut microbiota communities have coevolved for millions of years in a symbiotic relationship with their mammalian hosts. Elucidating and understanding the…”
Get full text

Metabolomics: the apogee of the omics trilogy by Patti, Gary J., Yanes, Oscar, Siuzdak, Gary

“…Metabolomics enables the comprehensive profiling of cellular metabolites at the systems level, thereby providing a direct readout of biochemical activity that…”
Get full text

Mass spectral databases for LC/MS- and GC/MS-based metabolomics: State of the field and future prospects by Vinaixa, Maria, Schymanski, Emma L., Neumann, Steffen, Navarro, Miriam, Salek, Reza M., Yanes, Oscar

“…•Mass spectral databases play a key role in metabolomics.•Advantages and limitations of public and commercial databases are underlined.•The overlap of…”
Get full text

FELLA: an R package to enrich metabolomics data by Picart-Armada, Sergio, Fernández-Albert, Francesc, Vinaixa, Maria, Yanes, Oscar, Perera-Lluna, Alexandre

“…Pathway enrichment techniques are useful for understanding experimental metabolomics data. Their purpose is to give context to the affected metabolites in…”
Get full text

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells by Ratajczak, Joanna, Joffraud, Magali, Trammell, Samuel A. J., Ras, Rosa, Canela, Núria, Boutant, Marie, Kulkarni, Sameer S., Rodrigues, Marcelo, Redpath, Philip, Migaud, Marie E., Auwerx, Johan, Yanes, Oscar, Brenner, Charles, Cantó, Carles

“…NAD + is a vital redox cofactor and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases…”
Get full text

The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming by Panopoulos, Athanasia D, Yanes, Oscar, Ruiz, Sergio, Kida, Yasuyuki S, Diep, Dinh, Tautenhahn, Ralf, Herrerías, Aída, Batchelder, Erika M, Plongthongkum, Nongluk, Lutz, Margaret, Berggren, W Travis, Zhang, Kun, Evans, Ronald M, Siuzdak, Gary, Belmonte, Juan Carlos Izpisua

“…Metabolism is vital to every aspect of cell function, yet the metabolome of induced pluripotent stem cells （iPSCs） remains largely unexplored. Here we report,…”
Get full text

Expanding Coverage of the Metabolome for Global Metabolite Profiling by Yanes, Oscar, Tautenhahn, Ralf, Patti, Gary J, Siuzdak, Gary

“…Mass spectrometry-based metabolomics is the comprehensive study of naturally occurring small molecules collectively known as the metabolome. Given the vast…”
Get full text

Metabolic oxidation regulates embryonic stem cell differentiation by Ding, Sheng, Siuzdak, Gary, Yanes, Oscar, Clark, Julie, Wong, Diana M, Patti, Gary J, Sánchez-Ruiz, Antonio, Benton, H Paul, Trauger, Sunia A, Desponts, Caroline

“…Metabolomics analysis of stem cells and differentiated cells points to chemical unsaturation as a key feature of stem cell metabolites. Manipulation of these…”
Get full text

iMet: A Network-Based Computational Tool To Assist in the Annotation of Metabolites from Tandem Mass Spectra by Aguilar-Mogas, Antoni, Sales-Pardo, Marta, Navarro, Miriam, Guimerà, Roger, Yanes, Oscar

“…Structural annotation of metabolites relies mainly on tandem mass spectrometry (MS/MS) analysis. However, approximately 90% of the known metabolites reported…”
Get full text

CliqueMS: a computational tool for annotating in-source metabolite ions from LC-MS untargeted metabolomics data based on a coelution similarity network by Senan, Oriol, Aguilar-Mogas, Antoni, Navarro, Miriam, Capellades, Jordi, Noon, Luke, Burks, Deborah, Yanes, Oscar, Guimerà, Roger, Sales-Pardo, Marta

“…Abstract Motivation The analysis of biological samples in untargeted metabolomic studies using LC-MS yields tens of thousands of ion signals. Annotating these…”
Get full text

ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling by Wright, Roni H. G., Lioutas, Antonios, Le Dily, Francois, Soronellas, Daniel, Pohl, Andy, Bonet, Jaume, Nacht, A. S., Samino, Sara, Font-Mateu, Jofre, Vicent, Guillermo P., Wierer, Michael, Trabado, Miriam A., Schelhorn, Constanze, Carolis, Carlo, Macias, Maria J., Yanes, Oscar, Oliva, Baldo, Beato, Miguel

“…Key nuclear processes in eukaryotes, including DNA replication, repair, and gene regulation, require extensive chromatin remodeling catalyzed by…”
Get full text

Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin by Patti, Gary J., Yanes, Oscar, Shriver, Leah P, Courade, Jean-Phillipe, Tautenhahn, Ralf, Manchester, Marianne, Siuzdak, Gary

“…Untargeted metabolomics reveals a dysregulation of sphingolipid production during neuropathic pain exemplified by N , N -dimethylsphingosine, whose…”
Get full text

Exhaled volatile organic compounds analysis in clinical pediatrics: a systematic review by Sola Martínez, Rosa A., Pastor Hernández, José M., Yanes Torrado, Óscar, Cánovas Díaz, Manuel, de Diego Puente, Teresa, Vinaixa Crevillent, María

“…Background Measured exhaled volatile organic compounds (VOCs) in breath also referred to as exhaled volatilome have been long claimed as a potential source of…”
Get full text

Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells by Bueno, Maria J., Jimenez-Renard, Veronica, Samino, Sara, Capellades, Jordi, Junza, Alejandra, López-Rodríguez, María Luz, Garcia-Carceles, Javier, Lopez-Fabuel, Irene, Bolaños, Juan P., Chandel, Navdeep S., Yanes, Oscar, Colomer, Ramon, Quintela-Fandino, Miguel

“…Upregulation of fatty acid synthase (FASN) is a common event in cancer, although its mechanistic and potential therapeutic roles are not completely understood…”
Get full text