Search Results - "Yanda, K."

Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease by Cebotaru, Liudmila, Liu, Qiangni, Yanda, Murali K, Boinot, Clement, Outeda, Patricia, Huso, David L, Watnick, Terry, Guggino, William B, Cebotaru, Valeriu

“…Abnormal proliferation of cyst-lining epithelium and increased intracystic fluid secretion via the cystic fibrosis transmembrane conductance regulator (CFTR)…”
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VX‐809 mitigates disease in a mouse model of autosomal dominant polycystic kidney disease bearing the R3277C human mutation by Yanda, Murali K., Cebotaru, Liudmila

“…Autosomal dominant polycystic kidney disease (ADPKD) is associated with the formation of renal cysts. We have devised a therapeutic approach, based on…”
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Ameliorating liver disease in an autosomal recessive polycystic kidney disease mouse model by Yanda, Murali K, Zeidan, Adi, Cebotaru, Liudmila

“…Systemic and portal hypertension, liver fibrosis, and hepatomegaly are manifestations associated with autosomal recessive polycystic kidney disease (ARPKD),…”
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A potential strategy for reducing cysts in autosomal dominant polycystic kidney disease with a CFTR corrector by Yanda, Murali K., Liu, Qiangni, Cebotaru, Liudmila

“…Autosomal dominant polycystic kidney disease (ADPKD) is associated with progressive enlargement of cysts, leading to a decline in function and renal failure…”
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An inhibitor of histone deacetylase 6 activity, ACY-1215, reduces cAMP and cyst growth in polycystic kidney disease by Yanda, Murali K, Liu, Qiangni, Cebotaru, Liudmila

“…Adult-onset autosomal-dominant polycystic kidney disease (ADPKD) is caused by mutations in either the or gene, leading to malfunction of their gene products,…”
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CFTR and PC2, partners in the primary cilia in autosomal dominant polycystic kidney disease by Yanda, Murali K, Ciobanu, Cristian, Guggino, William B, Cebotaru, Liudmila

“…Defects in the primary cilium are associated with autosomal dominant polycystic kidney disease (ADPKD). We used a combination of animal models, Western…”
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Pharmacological reversal of renal cysts from secretion to absorption suggests a potential therapeutic strategy for managing autosomal dominant polycystic kidney disease by Yanda, Murali K., Cha, Boyoung, Cebotaru, Cristina V., Cebotaru, Liudmila

“…Autosomal-dominant polycystic kidney disease (ADPKD) induces a secretory phenotype, resulting in multiple fluid-filled cysts. We have previously demonstrated…”
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Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease by Yanda, Murali K., Liu, Qiangni, Cebotaru, Valeriu, Guggino, William B., Cebotaru, Liudmila

“…Autosomal dominant polycystic kidney disease (ADPKD) is associated with progressive enlargement of multiple renal cysts, often leading to renal failure that…”
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Short-Term Steroid Treatment of Rhesus Macaque Increases Transduction by Yanda, Murali K, Tomar, Vartika, Cebotaru, Cristina Valeria, Guggino, William B, Cebotaru, Liudmila

“…Repeat dosing poses a major hurdle for the development of an adeno-associated virus (AAV)-based gene therapy for cystic fibrosis, in part because of the…”
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A new role for heat shock factor 27 in the pathophysiology of Clostridium difficile toxin B by Yanda, Murali K, Guggino, William B, Cebotaru, Liudmila

“…(CD) is a common pathogen that causes severe gastrointestinal inflammatory diarrhea in patients undergoing antibiotic therapy. Its virulence derives from two…”
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The Mitochondrial Ca2+ import complex is altered in ADPKD by Yanda, Murali K, Tomar, Vartika, Cole, Robert, Guggino, William B., Cebotaru, Liudmila

“…•ADPKD is associated with altered mitochondrial calcium uptake which fuels cyst growth.•87 characters. Mutations in either of the polycystic kidney disease…”
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Role of calcium in adult onset polycystic kidney disease by Yanda, Murali K., Liu, Qiangni, Cebotaru, Valeriu, Guggino, William B., Cebotaru, Liudmila

“…Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in genes encoding the polycystin (PC) 1 and 2 proteins. The goal of this study was…”
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Therapeutic Potential for CFTR Correctors in Autosomal Recessive Polycystic Kidney Disease by Yanda, Murali K., Tomar, Vartika, Cebotaru, Liudmila

“…Autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in PKHD1, encoding fibrocystin/polyductin (FPC). Severe disease occurs in…”
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Mo1284 C. difficile Toxin B Increases Chloride Secretion in CaCo2 Cells by Yanda, Murali K, Boinot, Clement, Sabirzhanova, Inna, Guggino, William, Cebotaru, Liudmila

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Rescue of CFTR NBD2 mutants N1303K and S1235R is influenced by the functioning of the autophagosome by Liu, Qiangni, Sabirzhanova, Inna, Yanda, Murali K., Bergbower, Emily A.S., Boinot, Clément, Guggino, William B., Cebotaru, Liudmila

“…The missing phenylalanine at position 508, located in nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane regulator (CFTR), is the most…”
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Reproductive health and human rights by Yanda, K., Smith, S.V., Rosenfield, A.

“…Reproductive health programs should adopt an approach based on human rights at the levels of clinical management as well as national policy, especially those…”
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Therapeutic Potential for CFTR Correctors in Autosomal Recessive Polycystic Kidney DiseaseSummary by Murali K. Yanda, Vartika Tomar, Liudmila Cebotaru

“…Background & Aims: Autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in PKHD1, encoding fibrocystin/polyductin (FPC). Severe disease…”
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Rituximab inhibits Kv1.3 channels in human B lymphoma cells via activation of FcγRIIB receptors by Wang, Li-Hua, Wang, Ning, Lu, Xiao-Yu, Liu, Bing-Chen, Yanda, Murali K., Song, John Z., Dai, Helena M., Sun, Yu-Liang, Bao, Hui-Fang, Eaton, Douglas C., Ma, He-Ping

“…Kv1.3 channels play an important role in modulating lymphocyte proliferation and apoptosis. We hypothesized that Kv1.3 channels in B lymphocytes might be…”
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Role of CFTR in Autosomal Dominant Polycystic Kidney Disease: FR-PO272 by Cebotaru, Liudmila, Yanda, Murali K.

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Treatment of Autosomal Recessive Polycystic Kidney Disease With CFTR Modulators: TH-PO414 by Cebotaru, Liudmila, Yanda, Murali K.

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