Search Results - "Yancopoulos, G D"

Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement by Orengo, J. M., Radin, A. R., Kamat, V., Badithe, A., Ben, L. H., Bennett, B. L., Zhong, S., Birchard, D., Limnander, A., Rafique, A., Bautista, J., Kostic, A., Newell, D., Duan, X., Franklin, M. C., Olson, W., Huang, T., Gandhi, N. A., Lipsich, L., Stahl, N., Papadopoulos, N. J., Murphy, A. J., Yancopoulos, G. D.

“…Acute allergic symptoms are caused by allergen-induced crosslinking of allergen-specific immunoglobulin E (IgE) bound to Fc-epsilon receptors on effector…”
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Delta-Like Ligand 4 (Dll4) Is Induced by VEGF as a Negative Regulator of Angiogenic Sprouting by Lobov, I. B., Renard, R. A., Papadopoulos, N., Gale, N. W., Thurston, G., Yancopoulos, G. D., Wiegand, S. J.

“…Genetic deletion studies have shown that haploinsufficiency of Delta-like ligand (Dll) 4, a transmembrane ligand for the Notch family of receptors, results in…”
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Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1 by Thurston, G., Suri, C., Smith, K., McClain, J., Sato, T. N., Yancopoulos, G. D., McDonald, D. M.

“…Angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF) are endothelial cell-specific growth factors. Direct comparison of transgenic mice…”
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Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF by Holash, J., Maisonpierre, P. C., Compton, D., Boland, P., Alexander, C. R., Zagzag, D., Yancopoulos, G. D., Wiegand, S. J.

“…In contrast with the prevailing view that most tumors and metastases begin as avascular masses, evidence is presented here that a subset of tumors instead…”
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New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF by Holash, J, Wiegand, S J, Yancopoulos, G D

“…Our analyses in several different tumor settings challenge the prevailing view that malignancies and metastases generally initiate as avascular masses that…”
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Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development by Gale, N W, Yancopoulos, G D

“…The term `vasculogenesis' refers to the earliest stages of vascular development, during which vascular endothelial cell precursors undergo differentiation,…”
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Ciliary Neurotrophic Factor Activates Leptin-like Pathways and Reduces Body Fat, without Cachexia or Rebound Weight Gain, Even in Leptin-Resistant Obesity by Lambert, P. D., Anderson, K. D., Sleeman, M. W., Wong, V., Tan, J., Hijarunguru, A., Corcoran, T. L., Murray, J. D., Thabet, K. E., Yancopoulos, G. D., Wiegand, S. J.

“…Ciliary Neurotrophic Factor (CNTF) was first characterized as a trophic factor for motor neurons in the ciliary ganglion and spinal cord, leading to its…”
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Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy by Bodine, Sue C., Latres, Esther, Baumhueter, Susanne, Venus K.-M. Lai, Nunez, Lorna, Clarke, Brian A., Poueymirou, William T., Panaro, Frank J., Na, Erqian, Dharmarajan, Kumar, Pan, Zhen-Qiang, Valenzuela, David M., DeChiara, Thomas M., Stitt, Trevor N., Yancopoulos, George D., Glass, David J.

“…Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of muscle atrophy, we performed…”
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The angiopoietins: Yin and Yang in angiogenesis by Davis, S, Yancopoulos, G D

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Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury by Tanaka, M., Endo, S., Okuda, T., Economides, A.N., Valenzuela, D.M., Murphy, A.J., Robertson, E., Sakurai, T., Fukatsu, A., Yancopoulos, G.D., Kita, T., Yanagita, M.

“…Once developed, end-stage renal disease cannot be reversed by any current therapy. Bone morphogenetic protein-7 (BMP-7), however, is a possible treatment for…”
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Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands by Holland, Sacha J, Gale, Nicholas W, Mbamalu, Geraldine, Yancopoulos, George D, Henkemeyer, Mark, Pawson, Tony

“…Receptor tyrosine kinases of the EPH class have been implicated in the control of axon guidance and fasciculation, in regulating cell migration, and in…”
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VEGF-initiated Blood-Retinal Barrier Breakdown in Early Diabetes by Qaum, Tamim, Xu, Qingwen, Joussen, Antonia M, Clemens, Mark W, Qin, Wenying, Miyamoto, Kazuaki, Hassessian, Haroutioun, Wiegand, Stanley J, Rudge, John, Yancopoulos, George D, Adamis, Anthony P

“…The objectives of this study were to (1) determine whether endogenous vascular endothelial growth factor (VEGF) triggers diabetic blood-retinal barrier…”
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Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis by Torres, R, Macdonald, L, Croll, S D, Reinhardt, J, Dore, A, Stevens, S, Hylton, D M, Rudge, J S, Liu-Bryan, R, Terkeltaub, R A, Yancopoulos, G D, Murphy, A J

“…Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystal-induced interleukin 1 beta (IL1beta) release contributes to inflammation in…”
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Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice by Sleeman, M.W, Garcia, K, Liu, R, Murray, J.D, Malinova, L, Moncrieffe, M, Yancopoulos, G.D, Wiegand, S.J

“…Obesity plays a central role in the development of insulin resistance and type 2 diabetes. We therefore examined the effects of a modified form of ciliary…”
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Essential role for oncogenic Ras in tumour maintenance by Chin, Lynda, DePinho#, Ronald A, Tam, Alice, Pomerantz, Jason, Wong, Michelle, Holash, Jocelyn, Bardeesy, Nabeel, Shen, Qiong, O'Hagan, Ronan, Pantginis, Joe, Zhou, Hao, Horner, James W, Cordon-Cardo, Carlos, Yancopoulos, George D

“…Advanced malignancy in tumours represents the phenotypic end-point of successive genetic lesions that affect the function and regulation of oncogenes and…”
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Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt by Rommel, Christian, Clarke, Brian A., Zimmermann, Sven, Nuñez, Lorna, Rossman, Roni, Reid, Kristina, Moelling, Karin, Yancopoulos, George D., Glass, David J.

“…Extracellular signals often result in simultaneous activation of both the RafMEK-ERK and PI3K-Akt pathways (where ERK is extracellular-regulated kinase, MEK is…”
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Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex by Croll, S.D., Suri, C., Compton, D.L., Simmons, M.V., Yancopoulos, G.D., Lindsay, R.M., Wiegand, S.J., Rudge, J.S., Scharfman, H.E.

“…Transgenic mice overexpressing brain-derived neurotrophic factor from the β-actin promoter were tested for behavioral, gross anatomical and physiological…”
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Angiopoietin-2, a Natural Antagonist for Tie2 that Disrupts In vivo Angiogenesis by Maisonpierre, Peter C., Suri, Chitra, Jones, Pamela F., Bartunkova, Sona, Wiegand, Stanley J., Radziejewski, Czeslaw, Compton, Debra, McClain, Joyce, Aldrich, Thomas H., Papadopoulos, Nick, Daly, Thomas J., Davis, Samuel, Sato, Thomas N., Yancopoulos, George D.

“…Angiogenesis is thought to depend on a precise balance of positive and negative regulation. Angiopoietin-1 (Ang1) is an angiogenic factor that signals through…”
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Increased Vascularization in Mice Overexpressing Angiopoietin-1 by Suri, Chitra, McClain, Joyce, Thurston, Gavin, McDonald, Donald M., Zhou, Hao, Oldmixon, Eben H., Sato, Thomas N., Yancopoulos, George D.

“…The angiopoietins and members of the vascular endothelial growth factor (VEGF) family are the only growth factors thought to be largely specific for vascular…”
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Tie2 Receptor Ligands, Angiopoietin-1 and Angiopoietin-2, Modulate VEGF-Induced Postnatal Neovascularization by Asahara, Takayuki, Chen, Donghui, Takahashi, Tomono, Fujikawa, Koshi, Kearney, Marianne, Magner, Meredith, Yancopoulos, George D, Isner, Jeffrey M

“…Angiopoietin-1 (Ang1) has been recently identified as the major physiological ligand for the tyrosine kinase receptor Tie2 and assigned responsibility for…”
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