Phytochemical, Antimicrobial, Antidiabetic, Thrombolytic, anticancer Activities, and in silico studies of Ficus palmata Forssk

Ficus palmata Forssk. (Moraceae family) is medicinally valuable plant that is mostly used as folk medicine for the treatment of differentdiseases. Phytochemical composition was evaluated by preliminary phytochemical investigation, GCMS analysis, and total bioactive contents (TPC and TFC). The antiox...

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Published in:	Arabian journal of chemistry Vol. 16; no. 2; p. 104455
Main Authors:	Al-Qahtani, Jawaher, Abbasi, Aliza, Aati, Hanan Y., Al-Taweel, Areej, Al-Abdali, Ali, Aati, Sultan, Yanbawi, Atheer N., Abbas Khan, Mohsin, Ahmad Ghalloo, Bilal, Anwar, Mariyam, Khan, Kashif-ur-Rehman
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-02-2023 Elsevier
Subjects:	ADME Anticancer HepG2 cell line Ficus palmata Forssk GCMS Molecular docking Thrombolytic Anticancer HepG2 cell line Thrombolytic GCMS ADME Molecular docking Ficus palmata Forssk
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Summary:	Ficus palmata Forssk. (Moraceae family) is medicinally valuable plant that is mostly used as folk medicine for the treatment of differentdiseases. Phytochemical composition was evaluated by preliminary phytochemical investigation, GCMS analysis, and total bioactive contents (TPC and TFC). The antioxidant, enzyme inhibition, antimicrobial, thrombolytic and anticancer activities were performed for biological evaluation. The extract exhibited the maximum total phenolic (49.24 ± 1.21 mg GAE/g) and total flavonoid contents (29.9 ± 1.13 mg QE/g) which may be correlated to higher antioxidant potential of extract. The GCMS investigation identified the presence of 27 phytocompounds of different classes related to aldehydes, esters of fatty acids, triterpenes, steroids, triterpenoid. The extract possessed the strong α-glucosidase (73.4 ± 4.65 %) and moderate α-amylase inhibition activity (47.1 ± 3.29 %). Significant results were observed in case of antiviral, antifungal, and antibacterial activities. F. palmata extract inhibited the growth of HepG2 cancer cells in a dose-dependent manner. The extract also exhibited moderate in vitro thrombolytic activity. In addition, the phytocompounds identified by GCMS were subjected to in silico molecular docking studies to analyze the binding affinity between phytocompounds and enzymes (α-glucosidase and α-amylase). Moreover, the best docked compounds were selected for ADMET studies which provide information about pharmacokinetics, physicochemical properties, drug-likeness, and toxicity of identified phytocompounds. The outcome of our research revealed that ethanolic extract of F. palmata possessed good antidiabetic, antimicrobial, thrombolytic and anticancer potential. This plant should be further explored to isolate the bioactive compounds for new drug development.
ISSN:	1878-5352 1878-5379
DOI:	10.1016/j.arabjc.2022.104455