Search Results - "Yan, Yijin"

Gene editing vectors for studying nicotinic acetylcholine receptors in cholinergic transmission by Peng, Can, Yan, Yijin, Kim, Veronica J., Engle, Staci E., Berry, Jennifer N., McIntosh, J. Michael, Neve, Rachael L., Drenan, Ryan M.

“…Nicotinic acetylcholine receptors (nAChRs), prototype members of the cys‐loop ligand‐gated ion channel family, are key mediators of cholinergic transmission in…”
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Blockade of Dopamine D4 Receptors Attenuates Reinstatement of Extinguished Nicotine-Seeking Behavior in Rats by YIJIN YAN, PUSHPARAJ, Abhiram, YANN LE STRAT, GAMALEDDIN, Islam, BARNES, Chanel, JUSTINOVA, Zuzana, GOLDBERG, Steven R, BERNARD LE FOIL

“…Since cloning of the dopamine receptor D4 (DRD4), its role in the brain has remained unclear. It has been reported that polymorphism of the DRD4 gene in humans…”
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Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission by Yan, Yijin, Peng, Can, Arvin, Matthew C., Jin, Xiao-Tao, Kim, Veronica J., Ramsey, Matthew D., Wang, Yong, Banala, Sambashiva, Wokosin, David L., McIntosh, J. Michael, Lavis, Luke D., Drenan, Ryan M.

“…Ventral tegmental area (VTA) glutamate neurons are important components of reward circuitry, but whether they are subject to cholinergic modulation is unknown…”
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Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain by Peng, Can, Engle, Staci E, Yan, Yijin, Weera, Marcus M, Berry, Jennifer N, Arvin, Matthew C, Zhao, Guiqing, McIntosh, J Michael, Chester, Julia A, Drenan, Ryan M

“…Nicotinic acetylcholine receptors containing α4 subunits (α4β2* nAChRs) are critical for nicotinic cholinergic transmission and the addictive action of…”
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Dissociable role of tumor necrosis factor alpha gene deletion in methamphetamine self-administration and cue-induced relapsing behavior in mice by Yan, Yijin, Nitta, Atsumi, Koseki, Takenao, Yamada, Kiyofumi, Nabeshima, Toshitaka

“…Rationale During the development of addiction, addictive drugs induce transient and long-lasting changes in the brain including expression of endogenous…”
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Mouse model of relapse to the abuse of drugs: Procedural considerations and characterizations by Yan, Yijin, Nabeshima, Toshitaka

“…To identify genetic risk factors involved in relapse to the abuse of drugs in humans, it is essential for researchers to develop a reliable mouse model of…”
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Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial cell line-derived neurotrophic factor mutant mice by Yan, Yijin, Yamada, Kiyofumi, Niwa, Minae, Nagai, Taku, Nitta, Atsumi, Nabeshima, Toshitaka

“…Genetic factors are considered to play an important role in drug dependence/addiction including the development of drug dependence and relapse. With the use of…”
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Intrastriatal gene delivery of GDNF persistently attenuates methamphetamine self-administration and relapse in mice by Yan, Yijin, Miyamoto, Yoshiaki, Nitta, Atsumi, Muramatsu, Shin-ichi, Ozawa, Keiya, Yamada, Kiyofumi, Nabeshima, Toshitaka

“…Relapse of drug abuse after abstinence is a major challenge to the treatment of addicts. In our well-established mouse models of methamphetamine (Meth)…”
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Transient drug-primed but persistent cue-induced reinstatement of extinguished methamphetamine-seeking behavior in mice by Yan, Yijin, Yamada, Kiyofumi, Nitta, Atsumi, Nabeshima, Toshitaka

“…It is essential to develop animal models to study the role of genetic factors in the relapse of drug-seeking behavior in genetically engineered mutant mice…”
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Relapse of methamphetamine-seeking behavior in C57BL/6J mice demonstrated by a reinstatement procedure involving intravenous self-administration by Yan, Yijin, Nitta, Atsumi, Mizoguchi, Hiroyuki, Yamada, Kiyofumi, Nabeshima, Toshitaka

“…There is an urgent need to develop a reliable mouse model of relapse to address the genetic factors involved in susceptibility to relapse of drug-seeking…”
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Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds by Yan, Yijin, Nitta, Atsumi, Mizuno, Tomoko, Nakajima, Akira, Yamada, Kiyofumi, Nabeshima, Toshitaka

“…Animal models of drug discrimination have been used to examine the subjective effects of addictive substances. The cAMP system is a crucial downstream…”
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Interleukin-6 protects PC12 cells from 4-hydroxynonenal-induced cytotoxicity by increasing intracellular glutathione levels by Nakajima, Akira, Yamada, Kiyofumi, Zou, Li-Bo, Yan, Yijin, Mizuno, Makoto, Nabeshima, Toshitaka

“…Oxidative stress plays an important role in neuronal cell death associated with many different neurodegenerative conditions, and it is reported that…”
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Nucleus accumbens feedforward inhibition circuit promotes cocaine self-administration by Yu, Jun, Yan, Yijin, Li, King-Lun, Wang, Yao, Huang, Yanhua H., Urban, Nathaniel N., Nestler, Eric J., Schlüter, Oliver M., Dong, Yan

“…The basolateral amygdala (BLA) sends excitatory projections to the nucleus accumbens (NAc) and regulates motivated behaviors partially by activating NAc medium…”
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Cocaine-Induced Synaptic Alterations in Thalamus to Nucleus Accumbens Projection by Neumann, Peter A, Wang, Yicun, Yan, Yijin, Wang, Yao, Ishikawa, Masago, Cui, Ranji, Huang, Yanhua H, Sesack, Susan R, Schlüter, Oliver M, Dong, Yan

“…Exposure to cocaine induces addiction-associated behaviors partially through remodeling neurocircuits in the nucleus accumbens (NAc). The paraventricular…”
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Chronic Nicotine Exposure Alters the Neurophysiology of Habenulo-Interpeduncular Circuitry by Arvin, Matthew C, Jin, Xiao-Tao, Yan, Yijin, Wang, Yong, Ramsey, Matthew D, Kim, Veronica J, Beckley, Nicole A, Henry, Brittany A, Drenan, Ryan M

“…Antagonism of nicotinic acetylcholine receptors (nAChRs) in the medial habenula (MHb) or interpeduncular nucleus (IPN) triggers withdrawal-like behaviors in…”
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Varenicline decreases nicotine self-administration and cue-induced reinstatement of nicotine-seeking behaviour in rats when a long pretreatment time is used by Le Foll, Bernard, Chakraborty-Chatterjee, Munmun, Lev-Ran, Shaul, Barnes, Chanel, Pushparaj, Abhiram, Gamaleddin, Islam, Yan, Yijin, Khaled, Maram, Goldberg, Steven R.

“…Effects of varenicline (Champix), a nicotinic partial agonist, were evaluated on subjective effects of nicotine (drug discrimination), motivation for nicotine…”
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Genes and molecules that can potentiate or attenuate psychostimulant dependence: relevance of data from animal models to human addiction by Niwa, Minae, Yan, Yijin, Nabeshima, Toshitaka

“…Recent evidence suggests that a variety of molecule products play critical roles in the transitions from recreational drug use to drug abuse, and then to drug…”
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Differential Nicotinic Modulation of Glutamatergic and GABAergic VTA Microcircuits by Yan, Yijin, Beckley, Nicole A, Kim, Veronica J, Drenan, Ryan M

“…Ventral tegmental area (VTA) neurons receive glutamatergic and/or GABAergic input from other local neurons within the VTA. Nicotinic acetylcholine receptor…”
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Altered nicotine reward-associated behavior following [alpha]4 nAChR subunit deletion in ventral midbrain by Peng, Can, Engle, Staci E, Yan, Yijin, Weera, Marcus M, Berry, Jennifer N, Arvin, Matthew C, Zhao, Guiqing, McIntosh, J. Michael, Chester, Julia A, Drenan, Ryan M

“…Nicotinic acetylcholine receptors containing [alpha]4 subunits ([alpha]4[beta]2* nAChRs) are critical for nicotinic cholinergic transmission and the addictive…”
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Dopamine D1 and D3 receptors mediate reconsolidation of cocaine memories in mouse models of drug self-administration by Yan, Y, Newman, A.H, Xu, M

“…Highlights • Pharmacological blockade of D1 or D3 receptors disrupts reconsolidation of cocaine memory. • Genetic mutations in D3 receptors attenuate…”
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