Search Results - "Yan, Victoria"

Test of 5- Versus 10-Day Remdesivir Treatment in Immunocompromised Patients With Coronavirus Disease 2019 by Yan, Victoria C

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Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment by Yan, Victoria C, Muller, Florian L

“…While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis…”
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Clinical pharmacodynamics of obeldesivir versus remdesivir by Faghihi, Isa, Yan, Victoria C

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Remdesivir treatment does not reduce viral titers in patients with COVID-19 by Faghihi, Isa, Yan, Victoria C

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Why Remdesivir Failed: Preclinical Assumptions Overestimate the Clinical Efficacy of Remdesivir for COVID-19 and Ebola by Yan, Victoria C, Muller, Florian L

“…Remdesivir is a nucleoside monophosphoramidate prodrug that has been FDA approved for coronavirus disease 2019 (COVID-19). However, the clinical efficacy of…”
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Phosphoramidate Prodrugs Continue to Deliver: The Journey of Remdesivir (GS-5734) from the Liver to Peripheral Blood Mononuclear Cells by Yan, Victoria C

“…Remdesivir (GS-5734) is a monophenol, 2-ethylbutylalanine phosphoramidate prodrug of GS-441524 that is FDA-approved for the treatment of patients hospitalized…”
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Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity by Yan, Victoria C, Muller, Florian L

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Remdesivir for COVID-19: Why Not Dose Higher? by Yan, Victoria C, Muller, Florian L

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NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis by Park, Mi Kyung, Zhang, Li, Min, Kyung-Won, Cho, Jung-Hyun, Yeh, Chih-Chen, Moon, Hyesu, Hormaechea-Agulla, Daniel, Mun, Hyejin, Ko, Seungbeom, Lee, Ji Won, Jathar, Sonali, Smith, Aubrey S, Yao, Yixin, Giang, Nguyen Thu, Vu, Hong Ha, Yan, Victoria C, Bridges, Mary C, Kourtidis, Antonis, Muller, Florian, Chang, Jeong Ho, Song, Su Jung, Nakagawa, Shinichi, Hirose, Tetsuro, Yoon, Je-Hyun, Song, Min Sup

“…Accelerated glycolysis is the main metabolic change observed in cancer, but the underlying molecular mechanisms and their role in cancer progression remain…”
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Single-Cell RNA Sequencing Supports Preferential Bioactivation of Remdesivir in the Liver by Yan, Victoria C, Muller, Florian L

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Quantitative Analysis of Salivary Cortisol Using LC-MS/MS by Zhang, Yan Victoria

“…Cortisol is one of the most important glucocorticoids and plays important roles in regulating human metabolism. Midnight salivary cortisol has been shown to…”
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Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology by Garg, Uttam, Zhang, Yan Victoria

“…Mass spectrometry (MS) has been used in research and specialized clinical laboratories for decades as a very powerful technology to identify and quantify…”
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Role of α-Catenin and its mechanosensing properties in regulating Hippo/YAP-dependent tissue growth by Sarpal, Ritu, Yan, Victoria, Kazakova, Lidia, Sheppard, Luka, Yu, Jessica C, Fernandez-Gonzalez, Rodrigo, Tepass, Ulrich

“…α-catenin is a key protein of adherens junctions (AJs) with mechanosensory properties. It also acts as a tumor suppressor that limits tissue growth. Here we…”
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An Optimized Bioassay for Screening Combined Anticoronaviral Compounds for Efficacy against Feline Infectious Peritonitis Virus with Pharmacokinetic Analyses of GS-441524, Remdesivir, and Molnupiravir in Cats by Cook, Sarah, Wittenburg, Luke, Yan, Victoria C, Theil, Jacob H, Castillo, Diego, Reagan, Krystle L, Williams, Sonyia, Pham, Cong-Dat, Li, Chun, Muller, Florian L, Murphy, Brian G

“…Feline infectious peritonitis (FIP) is a fatal disease of cats that currently lacks licensed and affordable vaccines or antiviral therapeutics. The disease has…”
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Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine by Barekatain, Yasaman, Ackroyd, Jeffrey J., Yan, Victoria C., Khadka, Sunada, Wang, Lin, Chen, Ko-Chien, Poral, Anton H., Tran, Theresa, Georgiou, Dimitra K., Arthur, Kenisha, Lin, Yu-Hsi, Satani, Nikunj, Ballato, Elliot S., Behr, Eliot I., deCarvalho, Ana C., Verhaak, Roel G. W., de Groot, John, Huse, Jason T., Asara, John M., Kalluri, Raghu, Muller, Florian L.

“…Homozygous deletion of methylthioadenosine phosphorylase ( MTAP ) in cancers such as glioblastoma represents a potentially targetable vulnerability. Homozygous…”
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Mass Spectrometry in Clinical Laboratory: Applications in Biomolecular Analysis by Garg, Uttam, Zhang, Yan Victoria

“…Mass spectrometry (MS) is a technique that can identify analytes on the basis of mass-to-charge (m/z) ratio. Although this technique has been used in research…”
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Enolase inhibitors as therapeutic leads for Naegleria fowleri infection by Milanes, Jillian E, Yan, Victoria C, Pham, Cong-Dat, Muller, Florian, Kwain, Samuel, Rees, Kerrick C, Dominy, Brian N, Whitehead, Daniel C, Millward, Steven W, Bolejack, Madison, Shek, Roger, Tillery, Logan, Phan, Isabelle Q, Staker, Bart, Moseman, E Ashley, Zhang, Xiang, Ma, Xipeng, Jebet, Audriy, Yin, Xinmin, Morris, James C

“…Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amoebic…”
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Quantification of Phosphonate Drugs by 1H–31P HSQC Shows That Rats Are Better Models of Primate Drug Exposure than Mice by Barekatain, Yasaman, Khadka, Sunada, Harris, Kristen, Delacerda, Jorge, Yan, Victoria C., Chen, Ko-Chien, Pham, Cong-Dat, Uddin, Md. Nasir, Avritcher, Rony, Eisenberg, Eugene J., Kalluri, Raghu, Millward, Steven W., Muller, Florian L.

“…The phosphonate group is a key pharmacophore in many antiviral, antimicrobial, and antineoplastic drugs. Due to its high polarity and short retention time,…”
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Prodrugs of a 1‑Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of ENO1-Deleted Cancers by Yan, Victoria C., Pham, Cong-Dat, Ballato, Elliot S., Yang, Kristine L., Arthur, Kenisha, Khadka, Sunada, Barekatain, Yasaman, Shrestha, Prakriti, Tran, Theresa, Poral, Anton H., Washington, Mykia, Raghavan, Sudhir, Czako, Barbara, Pisaneschi, Federica, Lin, Yu-Hsi, Satani, Nikunj, Hammoudi, Naima, Ackroyd, Jeffrey J., Georgiou, Dimitra K., Millward, Steven W., Muller, Florian L.

“…Cancers harboring homozygous deletion of the glycolytic enzyme enolase 1 (ENO1) are selectively vulnerable to inhibition of the paralogous isoform, enolase 2…”
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Correction: Cook et al. An Optimized Bioassay for Screening Combined Anticoronaviral Compounds for Efficacy against Feline Infectious Peritonitis Virus with Pharmacokinetic Analyses of GS-441524, Remdesivir, and Molnupiravir in Cats. Viruses 2022, 14 , 2429 by Cook, Sarah, Wittenburg, Luke, Yan, Victoria C, Theil, Jacob H, Castillo, Diego, Reagan, Krystle L, Williams, Sonyia, Pham, Cong-Dat, Li, Chun, Muller, Florian L, Murphy, Brian G

“…In the original publication [...]…”
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