Search Results - "Yan, Robert"
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The role of zinc in the stability of the marginally stable IscU scaffold protein
Published in Protein science (01-09-2014)“…Understanding the factors that determine protein stability is interesting because it directly reflects the evolutionary pressure coming from function and…”
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"Using dried blood spots beyond newborn screening - is Hong Kong ready?": navigating the intersection of innovation readiness, privacy concerns, and Chinese parenting culture
Published in BMC public health (26-10-2024)“…Newborn screening programmes offer an opportunity to obtain dried blood spots (DBS) cards that contain a wealth of biological information that can be stored…”
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Palivizumab for Infants < 29 Weeks in Hong Kong without a Clear-Cut Season for Respiratory Syncytial Virus Infection-A Cost-Effectiveness Analysis
Published in Journal of tropical pediatrics (1980) (01-10-2018)“…To evaluate the cost-effectiveness of palivizumab prophylaxis for premature infants born <29 weeks in Hong Kong. We evaluated the hospitalization rate for…”
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Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans
Published in Proceedings of the National Academy of Sciences - PNAS (20-09-2011)“…Candida albicans is the most prevalent fungal pathogen in humans and a major source of life-threatening nosocomial infections. The Ais (a̲gglutinin-l̲ike…”
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Public and Healthcare Provider Receptivity toward the Retention of Dried Blood Spot Cards and Their Usage for Extended Genetic Testing in Hong Kong
Published in International journal of neonatal screening (11-08-2023)“…Dried blood spot (DBS) cards from newborn screening (NBS) programs represent a wealth of biological data. They can be stored easily for a long time, have the…”
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The Eukaryotic-Specific ISD11 Is a Complex-Orphan Protein with Ability to Bind the Prokaryotic IscS
Published in PloS one (18-07-2016)“…The eukaryotic protein Isd11 is a chaperone that binds and stabilizes the central component of the essential metabolic pathway responsible for formation of…”
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A New Tessera into the Interactome of the isc Operon: A Novel Interaction between HscB and IscS
Published in Frontiers in molecular biosciences (27-09-2016)“…Iron sulfur clusters are essential universal prosthetic groups which can be formed inorganically but, in biology, are bound to proteins and produced…”
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Application of Selective Bronchial Intubation versus Neurally Adjusted Ventilatory Assist in the Management of Unilateral Pulmonary Interstitial Emphysema: An Illustrative Case and the Literature Review
Published in American journal of perinatology reports (01-04-2017)“…In the treatment of left-sided pulmonary interstitial emphysema (PIE) in a 23-week neonate, we used two ventilatory strategies: selective bronchial intubation…”
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Cluster and fold stability of E. coli ISC-type ferredoxin
Published in PloS one (12-11-2013)“…Iron-sulfur clusters are essential protein prosthetic groups that provide their redox potential to several different metabolic pathways. Formation of…”
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Low-level chronic mercury exposure in children and adolescents: Meta-analysis
Published in Pediatrics international (01-02-2007)“…Background: Mercury is a well‐known neurotoxin. There are three kinds of mercury exposure: elemental mercury poisoning, inorganic mercury poisoning and…”
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Development and multicenter case-control validation of urinary comprehensive genomic profiling for urothelial carcinoma diagnosis, surveillance, and risk prediction
Published in Clinical cancer research (15-09-2023)“…Urinary comprehensive genomic profiling (uCGP) uses next-generation sequencing to identify mutations associated with urothelial carcinoma (UC) and has the…”
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Histological chorioamnionitis - implication for bacterial colonization, laboratory markers of infection, and early onset sepsis in very-low-birth-weight neonates
Published in The journal of maternal-fetal & neonatal medicine (01-04-2012)“…Abstract Objective. The objective of this study was to evaluate the relationship between histological chorioamnionitis and laboratory markers of infection and…”
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Ferredoxin, in conjunction with NADPH and ferredoxin-NADP reductase, transfers electrons to the IscS/IscU complex to promote iron–sulfur cluster assembly
Published in Biochimica et biophysica acta (01-09-2015)“…Fe–S cluster biogenesis is an essential pathway coordinated by a network of protein–protein interactions whose functions include desulfurase activity,…”
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The Scaffold Protein IscU Retains a Structured Conformation in the FeS Cluster Assembly Complex
Published in Chembiochem : a European journal of chemical biology (21-07-2014)“…IscU and IscS are two essential proteins in the machine responsible for the biogenesis of iron–sulfur clusters, prosthetic groups that are involved in several…”
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Obstructive sleep apnea syndrome secondary to pharyngolaryngomalacia in a neonate with Down syndrome
Published in International journal of pediatric otorhinolaryngology (01-07-2005)“…We described a case of obstructive sleep apnea secondary (OSAS) to pharyngomalacia and laryngomalacia in a neonate with Down syndrome. She presented with…”
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Structural and functional characterization of a frataxin from a thermophilic organism
Published in The FEBS journal (01-02-2019)“…Frataxins form an interesting family of iron‐binding proteins with an almost unique fold and are highly conserved from bacteria to primates. They have a…”
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Understanding the role of dynamics in the iron sulfur cluster molecular machine
Published in Biochimica et biophysica acta. General subjects (01-01-2017)“…The bacterial proteins IscS, IscU and CyaY, the bacterial orthologue of frataxin, play an essential role in the biological machine that assembles the…”
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The Structure of the Pro-domain of Mouse proNGF in Contact with the NGF Domain
Published in Structure (London) (02-01-2019)“…Nerve growth factor (NGF) is an important neurotrophic factor involved in the regulation of cell differentiation and survival of target neurons. Expressed as a…”
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MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo
Published in Cell stem cell (04-04-2019)“…Heart disease is a paramount cause of global death and disability. Although cardiomyocyte death plays a causal role and its suppression would be logical, no…”
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