Search Results - "Yan, Qingran"

Botulinum toxin for Raynaud's phenomenon associated with systemic sclerosis: comment on the article by Senet et al by Yin, Hanlin, Liu, Bei, Li, Qianqian, Yan, Qingran, Lu, Liangjing

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GexMolGen: cross-modal generation of hit-like molecules via large language model encoding of gene expression signatures by Cheng, Jiabei, Pan, Xiaoyong, Fang, Yi, Yang, Kaiyuan, Xue, Yiming, Yan, Qingran, Yuan, Ye

“…Abstract Designing de novo molecules with specific biological activity is an essential task since it holds the potential to bypass the exploration of target…”
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High incidence and mortality of Pneumocystis jirovecii infection in anti-MDA5-antibody-positive dermatomyositis: experience from a single center by Huang, Linlin, Fu, Qiong, Ye, Yan, Lin, Yanwei, Yan, Qingran, Chen, Sheng

“…Idiopathic inflammatory myopathies (IIM) are associated with a significantly higher risk of opportunistic infections including Pneumocystis jirovecii pneumonia…”
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Endothelial Response to Type I Interferon Contributes to Vasculopathy and Fibrosis and Predicts Disease Progression of Systemic Sclerosis by Yin, Hanlin, Distler, Oliver, Shen, Lichong, Xu, Xiaojiang, Yuan, Ye, Li, Rui, Liu, Bei, Li, Qianqian, Huang, Qianru, Xie, Feng, Zhang, Zhiliang, Liang, Rui, Dai, Xueyu, Chen, Xiaoxiang, Li, Bin, Yan, Qingran, Lu, Liangjing

“…Objective Interferon (IFN)‐1 signatures are a hallmark of patients with systemic sclerosis (SSc). However, its significance in clinical stratification and…”
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Dihydroartemisinin alleviates skin fibrosis and endothelial dysfunction in bleomycin-induced skin fibrosis models by Li, Rui, Yin, Hanlin, Wang, Juan, He, Dongyi, Yan, Qingran, Lu, Liangjing

“…Objective The present study was to investigate whether dihydroartemisinin (DHA), which is a highly effective and safe drug in the treatment of malaria, could…”
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Oral IRAK4 inhibitor BAY-1834845 prevents acute respiratory distress syndrome by Li, Qianqian, Li, Rui, Yin, Hanlin, Wang, Suli, Liu, Bei, Li, Jun, Zhou, Mi, Yan, Qingran, Lu, Liangjing

“…Acute respiratory distress syndrome (ARDS) is a lethal clinical entity that has become an emergency event with the outbreak of COVID-19. However, to date,…”
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Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC/EGR1 axis by Ye, Yan, Liu, Mei, Tang, Longhai, Du, Fang, Liu, Yuanhua, Hao, Pei, Fu, Qiong, Guo, Qiang, Yan, Qingran, Zhang, Xiaoming, Bao, Chunde

“…This study aimed to explore the molecular mechanism and clinical relevance of iguratimod in the regulation of human B cell terminal differentiation. An in…”
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Duration biased distribution of clinical and immunological phenotypes in active SLE by Yan, Qingran, Liu, Bei, Yang, Minjie, Li, Qianqian, Wang, Jieying, Li, Ting, Lu, Liangjing

“…This study is aimed to map the clinical and immunological features of active lupus patients with different disease duration. For clinical phenotype analysis,…”
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Correction: Iguratimod attenuated fbrosis in systemic sclerosis via targeting early growth response 1 expression by Shen, Lichong, Yin, Hanlin, Sun, Li, Zhang, Zhiliang, Jin, Yuyang, Cao, Shan, Fu, Qiong, Fan, Chaofan, Bao, Chunde, Lu, Liangjing, Zhan, Yifan, Xu, Xiaojiang, Chen, Xiaoxiang, Yan, Qingran

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Iguratimod attenuated fibrosis in systemic sclerosis via targeting early growth response 1 expression by Shen, Lichong, Yin, Hanlin, Sun, Li, Zhang, Zhiliang, Jin, Yuyang, Cao, Shan, Fu, Qiong, Fan, Chaofan, Bao, Chunde, Lu, Liangjing, Zhan, Yifan, Xu, Xiaojiang, Chen, Xiaoxiang, Yan, Qingran

“…The early growth response 1 (EGR1) is a central transcription factor involved in systemic sclerosis (SSc) pathogenesis. Iguratimod is a synthesized…”
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Prevention of immune nephritis by the small molecular weight immunomodulator iguratimod in MRL/lpr mice by Yan, Qingran, Du, Fang, Huang, Xinfang, Fu, Qiong, Chen, Sheng, Dai, Dai, Bao, Chunde

“…This study was performed to investigate the therapeutic effects of iguratimod in a lupus mouse model. Female MRL/lpr mice were treated with iguratimod, vehicle…”
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Efficacy and safety of Iguratimod as an add-on therapy for refractory lupus nephritis: A preliminary investigational study by Yan, Qingran, Zhang, Mei, Du, Fang, Kang, Yuening, Ye, Ping, Li, Qianqian, Liu, Bei, Dai, Min, Bao, Chunde

“…IGU (IGU), a novel immunomodulatory agent for rheumatoid arthritis, has been shown to be effective and safe as monotherapy in a small population with…”
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Iguratimod as an alternative induction therapy for refractory lupus nephritis: a preliminary investigational study by Kang, Yuening, Yan, Qingran, Fu, Qiong, Wang, Ran, Dai, Min, Du, Fang, Dai, Qing, Ye, Ping, Wu, Chunmei, Lu, Liangjing, Bao, Chunde

“…Iguratimod, a novel immunomodulatory agent for rheumatoid arthritis, has been shown to be effective against murine lupus. The aim of this study was to make a…”
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Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency by Ma, Xiaojuan, Zhang, Shuang, Ren, Xiaochen, Feng, Yujie, Li, Hui, Chen, Shi, Xu, Jingen, Wang, Yanting, Peng, Guo-yuan, Yan, Qingran, Jia, Huifeng, Xia, Simin, Cui, Xiaopei, Chen, Xiaofang, Pan, Xianfei, Wang, Shaojie, Yu, Haijia, Wei, Xiaoyue, Li, Mingwei, Liu, Bei, Xu, Jingyue, Qian, Qiaoxia, Zhu, Xiangyang, Zhan, Yifan, Lu, Liangjing

“…Antibody drugs targeting single inflammatory cytokines have revolutionized the treatment of immune-mediated inflammatory diseases. To investigate whether dual…”
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Iguratimod as an alternative therapy for systemic sclerosis and prevention of the occurrence of ischemic digital ulcer by Yan, Qingran, Liu, Bei, Wang, Jieying, Yin, Hanlin, Li, Qianqian, Lu, Liangjing

“…This study aimed to assess the effectiveness of iguratimod (IGU) as an alternative treatment for systemic sclerosis (SSc), especially in the prevention of…”
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Comparison of iguratimod and conventional cyclophosphamide with sequential azathioprine as treatment of active lupus nephritis: study protocol for a multi-center, randomized, controlled clinical trial (iGeLU study) by Yan, Qingran, Du, Fang, Kang, Yuening, Ye, Ping, Wang, Xiaodong, Xu, Jianhua, Tang, Jianping, Wang, Niansong, Jiang, Gengru, Li, Zhijun, Wang, Xuan, Xue, Qin, Huang, Xinfang, Zhang, Xiaoyan, Zhou, Ying, Dai, Min, Bao, Chunde

“…Abstract Background Systemic lupus erythematosus (SLE) is an autoimmune disease that can involve multiple organs or systems. Lupus nephritis (LN) is associated…”
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Association of Cytomegalovirus Infection With Anti-MDA5 Antibody-Positive Dermatomyositis: A Prospective Cohort Study by Huang, Linlin, Zhu, Wenbo, Ye, Yan, Wu, Xiaoping, Yan, Qingran, Wang, Zhiqing, Lin, Yanwei, Chen, Sheng

“…Objectives: To investigate whether cytomegalovirus (CMV) infection plays a role in the pathogenesis and prognosis of idiopathic inflammatory myopathy (IIM),…”
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Quantitative infrapatellar fat pad signal intensity alteration as an imaging biomarker of knee osteoarthritis progression by Cen, Han, Yan, Qingran, Meng, Tao, Chen, Zhongshan, Zhu, Jimin, Wang, Yuanyuan, Ruan, Guangfeng, Wang, Tian, Han, Weiyu, Hunter, David, Ding, Changhai

“…ObjectiveTo determine the association of quantitative infrapatellar fat pad (IPFP) signal intensity alteration with knee osteoarthritis (OA)…”
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Targeting miR-155 to Treat Experimental Scleroderma by Yan, Qingran, Chen, Jie, Li, Wei, Bao, Chunde, Fu, Qiong

“…Scleroderma is a refractory autoimmune skin fibrotic disorder. Alterations of microRNAs in lesional skin could be a new approach to treating the disease. Here,…”
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Improving nail involvement in systemic sclerosis: an overlooked sign in follow-up? by Yin, Hanlin, Yan, Qingran, Li, Rui, Liu, Bei, Lu, Liangjing

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