Search Results - "Yan, Nieng"

Structural Biology of the Major Facilitator Superfamily Transporters by Yan, Nieng

“…The ancient and ubiquitous major facilitator superfamily (MFS) represents the largest secondary transporter family and plays a crucial role in a multitude of…”
Get full text

Structural advances for the major facilitator superfamily (MFS) transporters by Yan, Nieng

“…The major facilitator superfamily (MFS) is one of the largest groups of secondary active transporters conserved from bacteria to humans. MFS proteins…”
Get full text

A Glimpse of Membrane Transport through Structures—Advances in the Structural Biology of the GLUT Glucose Transporters by Yan, Nieng

“…The cellular uptake of glucose is an essential physiological process, and movement of glucose across biological membranes requires specialized transporters…”
Get full text

GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters by Deng, Dong, Yan, Nieng

“…Glucose is the primary fuel to life on earth. Cellular uptake of glucose is a fundamental process for metabolism, growth, and homeostasis. Three families of…”
Get full text

Cryo-EM analysis of a membrane protein embedded in the liposome by Yao, Xia, Fan, Xiao, Yan, Nieng

“…Membrane proteins (MPs) used to be the most difficult targets for structural biology when X-ray crystallography was the mainstream approach. With the…”
Get full text

Structural basis for the modulation of voltage-gated sodium channels by animal toxins by Shen, Huaizong, Li, Zhangqiang, Jiang, Yan, Pan, Xiaojing, Wu, Jianping, Cristofori-Armstrong, Ben, Smith, Jennifer J, Chin, Yanni K Y, Lei, Jianlin, Zhou, Qiang, King, Glenn F, Yan, Nieng

“…Animal toxins that modulate the activity of voltage-gated sodium (Na ) channels are broadly divided into two categories-pore blockers and gating modifiers. The…”
Get full text

Structural Basis of the Modulation of the Voltage‐Gated Calcium Ion Channel Cav1.1 by Dihydropyridine Compounds by Gao, Shuai, Yan, Nieng

“…1,4‐Dihydropyridines (DHP), the most commonly used antihypertensives, function by inhibiting the L‐type voltage‐gated Ca2+ (Cav) channels. DHP compounds…”
Get full text

Structural basis for the recognition of Sonic Hedgehog by human Patched1 by Gong, Xin, Qian, Hongwu, Cao, Pingping, Zhao, Xin, Zhou, Qiang, Lei, Jianlin, Yan, Nieng

“…The Hedgehog (Hh) pathway involved in development and regeneration is activated by the extracellular binding of Hh to the membrane receptor Patched (Ptch). We…”
Get full text

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins by Shen Huaizong, Liu Dongliang, Wu, Kun, Lei Jianlin, Nieng, Yan

“…Targeting sodium channelsVoltage-gated sodium (Nav) channels have been implicated in cardiac and neurological disorders. There are many subtypes of these…”
Get full text

Structure of human Cav2.2 channel blocked by the painkiller ziconotide by Gao, Shuai, Yao, Xia, Yan, Nieng

“…The neuronal-type (N-type) voltage-gated calcium (Ca v ) channels, which are designated Ca v 2.2, have an important role in the release of neurotransmitters 1…”
Get full text

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution by Shen, Huaizong, Zhou, Qiang, Pan, Xiaojing, Li, Zhangqiang, Wu, Jianping, Yan, Nieng

“…Voltage-gated sodium (Na ) channels are responsible for the initiation and propagation of action potentials. They are associated with a variety of…”
Get full text

Crystal structure of the human glucose transporter GLUT1 by Deng, Dong, Xu, Chao, Sun, Pengcheng, Wu, Jianping, Yan, Chuangye, Hu, Mingxu, Yan, Nieng

“…The glucose transporter GLUT1 catalyses facilitative diffusion of glucose into erythrocytes and is responsible for glucose supply to the brain and other…”
Get full text

Structure-based assessment of disease- related mutations in human voltage-gated sodium channels by Huang, Weiyun, Liu, Minhao, Yan, S. Frank, Yan, Nieng

“…Voltage-gated sodium （Nav） channels are essential for the rapid upstroke of action potentials and the propa- gation of electrical signals in nerves and…”
Get full text

Structural basis for pore blockade of human voltage-gated calcium channel Cav1.3 by motion sickness drug cinnarizine by Yao, Xia, Gao, Shuai, Yan, Nieng

Get full text

Structure of the Human Lipid Exporter ABCA1 by Qian, Hongwu, Zhao, Xin, Cao, Pingping, Lei, Jianlin, Yan, Nieng, Gong, Xin

“…ABCA1, an ATP-binding cassette (ABC) subfamily A exporter, mediates the cellular efflux of phospholipids and cholesterol to the extracellular acceptor…”
Get full text

The shape of human squalene epoxidase expands the arsenal against cancer by Brown, Andrew J., Chua, Ngee Kiat, Yan, Nieng

“…Squalene epoxidase (also known as squalene monooxygenase, EC 1.14.99.7) is a key rate-limiting enzyme in cholesterol biosynthesis. Anil Padyana and colleagues…”
Get full text

Structure of the voltage-gated calcium channel Cav1.1 complex by Wu, Jianping, Yan, Zhen, Li, Zhangqiang, Yan, Chuangye, Lu, Shan, Dong, Mengqiu, Yan, Nieng

“…The voltage-gated calcium channel Ca(v)1.1 is engaged in the excitation-contraction coupling of skeletal muscles. The Ca(v)1.1 complex consists of the…”
Get full text

Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm by Qian, Hongwu, Cao, Pingping, Hu, Miaohui, Gao, Shuai, Yan, Nieng, Gong, Xin

“…The Hedgehog (Hh) pathway controls embryonic development and postnatal tissue maintenance and regeneration. Inhibition of Hh receptor Patched (Ptch) by the Hh…”
Get full text

Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution by Wu, Jianping, Yan, Zhen, Li, Zhangqiang, Qian, Xingyang, Lu, Shan, Dong, Mengqiu, Zhou, Qiang, Yan, Nieng

“…The voltage-gated calcium (Ca v ) channels convert membrane electrical signals to intracellular Ca 2+ -mediated events. Among the ten subtypes of Ca v channel…”
Get full text

Structure of the Nav1.4-β1 Complex from Electric Eel by Yan, Zhen, Zhou, Qiang, Wang, Lin, Wu, Jianping, Zhao, Yanyu, Huang, Gaoxingyu, Peng, Wei, Shen, Huaizong, Lei, Jianlin, Yan, Nieng

“…Voltage-gated sodium (Nav) channels initiate and propagate action potentials. Here, we present the cryo-EM structure of EeNav1.4, the Nav channel from electric…”
Get full text