Modified calcium magnesium phosphate bone cement with improved microenvironment

Calcium magnesium phosphate bone cement (MCPC) has been widely used in bone defects restoration and attracted much attention due to excellent mechanical properties and biodegradability. However, excessive MgO tends to cause a local alkaline microenvironment which is adverse for cell growth and diffe...

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Bibliographic Details
Published in:	Ceramics international Vol. 48; no. 22; pp. 32929 - 32936
Main Authors:	Yan, Manqi, Zhao, Yanan, Dai, Yue, Yao, Xiaokang, Dai, Honglian
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 15-11-2022
Subjects:	Bone defect repair Calcium magnesium phosphate bone cement Gelatin Microenvironment Microenvironment Bone defect repair Gelatin Calcium magnesium phosphate bone cement
Online Access:	Get full text
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Summary:	Calcium magnesium phosphate bone cement (MCPC) has been widely used in bone defects restoration and attracted much attention due to excellent mechanical properties and biodegradability. However, excessive MgO tends to cause a local alkaline microenvironment which is adverse for cell growth and differentiation. In this work, we constructed the MCPC composites with improved microenvironment, enhanced osteogenic differentiation and biomineralization by introducing various concentrations of gelatin solutions. Gelatin played important roles in the improvement of physicochemical property, biodegradability, biocompatibility, osteogenic differentiation activity and biomineralization of MCPC. When incorporated with 1% and 5% of gelatin, the MCPC composites exhibited higher compressive strength and osteogenic differentiation ability of BMSCs in vitro. In conclusion, the modified MCPC composite is a potential candidate for bone defects repair and regenerate.
ISSN:	0272-8842 1873-3956
DOI:	10.1016/j.ceramint.2022.07.222