Search Results - "Yan, Lingli"

Icariside II Ameliorates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Inhibiting the Amyloidogenic Pathway: Involvement of BDNF/TrkB/CREB Signaling and Up-Regulation of PPARα and PPARγ in Rats by Yin, Caixia, Deng, Yuanyuan, Liu, Yuangui, Gao, Jianmei, Yan, Lingli, Gong, Qihai

“…Chronic cerebral hypoperfusion (CCH) is regarded as a high-risk factor for cognitive decline of vascular dementia (VD) as it is conducive to induce…”
Get full text

DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling by Zhang, Ke, Huang, Miaodan, Li, Ang, Wen, Jing, Yan, Lingli, Li, Yunhao, Guo, Liman, Senthil, Kumaran Satyanarayanan, Zhou, Yangyang, Chen, Guobing, Liu, Yong, Zhang, Xiaofei, Yao, Xiaoli, Qin, Dajiang, Su, Huanxing

“…Membraneless condensates, such as stress granules (SGs) and processing bodies (P-bodies), have attracted wide attention due to their unique feature of rapid…”
Get full text

Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer's Disease Model Mice Targeting Beta-Amyloid Production by Yan, Lingli, Deng, Yuanyuan, Gao, Jianmei, Liu, Yuangui, Li, Fei, Shi, Jingshan, Gong, Qihai

“…Icariside II (ICS II) is a broad-spectrum anti-cancer natural compound extracted from Maxim. Recently, the role of ICS II has been investigated in central…”
Get full text

Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway by Chong, Cheong-Meng, Tan, Yuan, Tong, Jiaqi, Ke, Minjing, Zhang, Ke, Yan, Lingli, Cen, Xiaotong, Lu, Jia-Hong, Chen, Guobing, Su, Huanxing, Qin, Dajiang

“…Abstract Background The mammalian target of rapamycin (mTOR) plays a critical role in controlling cellular homeostasis, and its dysregulation has been…”
Get full text

FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma by Zhang, Guangbing, Guo, Cuiyu, Wang, Yan, Zhang, Xianda, Liu, Shuang, Qu, Wen, Chen, Chunxia, Yan, Lingli, Yang, Zhouning, Zhang, Zhixiong, Jiang, Xiaohua, Chen, Xiaofeng, Liu, Hong, Lai, Qinhuai, Wei, Xian, Lu, Ying, Zhao, Shengyan, Deng, Han, Wang, Yuxi, Yu, Lin, Yu, Hongbin, Wu, Yu, Su, Zhaoming, Chen, Pengyu, Ren, Ziqing, Yu, Meng, Qu, Feng, Luo, Yong, Gou, Lantu, Li, Qing, Huang, Ying, Ma, Fanxin, Yang, Jinliang

“…Anti-CD38 monoclonal antibodies (mAbs), daratumumab, and isatuximab have represented a breakthrough in the treatment of multiple myeloma (MM). Recently,…”
Get full text

Fish oil protects the blood-brain barrier integrity in a mouse model of Alzheimer's disease by Xie, Youna, Yan, Lingli, Zeng, Haitao, Chen, Weineng, Lu, Jia-Hong, Wan, Jian-Bo, Su, Huanxing, Yao, Xiaoli

“…Alzheimer's disease (AD) is ranked as the most prevalent neurodegenerative disease. However, the exact molecular mechanisms underlying pathophysiological…”
Get full text

Critical factors in chimeric antigen receptor-modified T-cell (CAR-T) therapy for solid tumors by Yan, Lingli, Liu, Bainan

“…The success of chimeric antigen receptor-modified T-cell (CAR-T) therapy for B-cell lymphocyte malignancies targeting CD19 places it in a rapidly growing field…”
Get full text

Target selection of CAR T cell therapy in accordance with the TME for solid tumors by Liu, Bainan, Yan, Lingli, Zhou, Ming

“…Chimeric antigen receptor-engineered T (CAR T) cell therapy has made great progress in hematological malignancies and resulted in two newly FDA-approved drugs…”
Get full text

A “Bridge‐Building” Glycan Scaffold Mimicking Microbial Invasion for In Situ Endothelialization by Mu, Ruoyu, Zhang, Yuhan, Yan, Lingli, Liao, Zhencheng, Yang, Yushun, Su, Huanxing, Dong, Lei, Wang, Chunming

“…The globally high prevalence of peripheral artery diseases poses a pressing need for biomaterials grafts to rebuild vasculature. When implanted, they should…”
Get full text

Decision-Making Error in Platelet Transfusion Caused by EDTA-Dependent Pseudothrombocytopenia: a Case Report and Literature Review by Yan, Lingli, Xu, Shilan, Yang, Xinxin, Luo, Zhenglian, Huang, Chunyan

“…Ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia (EDTA-PTCP) is a rare phenomenon characterized by pseudo low platelet counts when using EDTA…”
Get more information

A “Bridge‐Building” Glycan Scaffold Mimicking Microbial Invasion for In Situ Endothelialization (Adv. Mater. 42/2021) by Mu, Ruoyu, Zhang, Yuhan, Yan, Lingli, Liao, Zhencheng, Yang, Yushun, Su, Huanxing, Dong, Lei, Wang, Chunming

“…In Situ Endothelialization In article number 2103490, Lei Dong, Chunming Wang, and co‐workers describe how fungal sugars in bioscaffold design are mimicked to…”
Get full text

Unraveling the impact of Omega-3 polyunsaturated fatty acids on blood-brain barrier (BBB) integrity and glymphatic function by Wen, Jing, Satyanarayanan, Senthil Kumaran, Li, Ang, Yan, Lingli, Zhao, Ziai, Yuan, Qiuju, Su, Kuan-Pin, Su, Huanxing

“…Alzheimer's disease (AD) and other forms of dementia represent major public health challenges but effective therapeutic options are limited. Pathological brain…”
Get full text

Therapeutic plasma exchange-free treatment for first-episode TTP: A systematic review by Wang, Jiang, Cheng, Fu, Niu, Yingying, Yan, Lingli, Li, Jiaheng, Tan, Bin, Qin, Li

“…Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy (TMA), and therapeutic plasma exchange (TPE) is currently the standard treatment…”
Get full text

Omega-3 polyunsaturated fatty acids promote brain-to-blood clearance of β-Amyloid in a mouse model with Alzheimer’s disease by Yan, Lingli, Xie, Youna, Satyanarayanan, Senthil Kumaran, Zeng, Haitao, Liu, Qiang, Huang, Miaodan, Ma, Yuemeng, Wan, Jian-Bo, Yao, Xiaoli, Su, Kuan-Pin, Su, Huanxing

“…•In APP/PS1 mice lipoprotein receptor-related protein-1 starts decreasing at 4 months of age.•Omega-3 PUFAs significantly enhanced LRP-1expression and promoted…”
Get full text

Experimental alcoholism primes structural and functional impairment of the glymphatic pathway by Liu, Qiang, Yan, Lingli, Huang, Miaodan, Zeng, Haitao, Satyanarayanan, Senthil Kumaran, Shi, Zhe, Chen, Dingbang, Lu, Jia-Hong, Pei, Zhong, Yao, Xiaoli, Su, Huanxing

“…•Acute alcohol treatment reduces the influx and efflux function of the glymphatic system.•The impairment of glymphatic function induced by acute alcohol…”
Get full text

PRDX1 is a Tumor Suppressor for Nasopharyngeal Carcinoma by Inhibiting PI3K/AKT/TRAF1 Signaling by Xiao, Hongmei, Yang, Taoyu, Yan, Lingli, Feng, Jihong, Huang, Boyan, Jiang, Yu

“…Peroxiredoxin 1 (PRDX1) has been identified as a dual regulator of tumorigenesis. However, its expression, clinical significance, and biological function in…”
Get full text

Codon optimization significantly enhanced the expression of human 37-kDa iLRP in Escherichia coli by Liu, Bainan, Kong, Qianqian, Zhang, Dong, Yan, Lingli

“…37-kDa immature laminin receptor protein (iLRP), the precursor of 67-kDa laminin receptor protein (LRP), is overexpressed on the surface of most cancer cells…”
Get full text

Cellular and molecular mechanisms in vascular repair after traumatic brain injury: a narrative review by Zhao, Zi-Ai, Yan, Lingli, Wen, Jing, Satyanarayanan, Senthil Kumaran, Yu, Feng, Lu, Jiahong, Liu, Yong U, Su, Huanxing

“…Abstract Traumatic brain injury (TBI) disrupts normal brain function and is associated with high morbidity and fatality rates. TBI is characterized as mild,…”
Get full text

Comparison between the effects of normoxia and hypoxia on antioxidant enzymes and glutathione redox state in ex vivo culture of CD34 + cells by Fan, Jinli, Cai, Haibo, Yang, Shi, Yan, Lingli, Tan, WenSong

“…Hypoxia maintained biological characteristics of CD34 + cells through keeping lower intracellular reactive oxygen specials (ROS) levels. The effects of…”
Get full text

Gene expression profiling of hypoxia and reduced ROS effects on ex vivo expanded human CD34 +CD38 − cells by Fan, Jinli, Cai, Haibo, Yang, Shi, Yan, Lingli, Tan, Wensong

Get full text