Search Results - "Yan, Liang‐jun"

Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases by Das, Nilanjana, Jana, Chandan Kumar, Yan, Liang-Jun, Nandi, Ankita

“…Reactive species produced in the cell during normal cellular metabolism can chemically react with cellular biomolecules such as nucleic acids, proteins, and…”
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Redox imbalance stress in diabetes mellitus: Role of the polyol pathway by Yan, Liang‐jun

“…In diabetes mellitus, the polyol pathway is highly active and consumes approximately 30% glucose in the body. This pathway contains 2 reactions catalyzed by…”
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Folic acid‐induced animal model of kidney disease by Yan, Liang‐Jun

“…The kidneys are a vital organ that is vulnerable to both acute kidney injury (AKI) and chronic kidney disease (CKD) which can be caused by numerous risk…”
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Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress by Yan, Liang-Jun

“…Chronic overnutrition creates chronic hyperglycemia that can gradually induce insulin resistance and insulin secretion impairment. These disorders, if not…”
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Cadmium-Induced Kidney Injury: Oxidative Damage as a Unifying Mechanism by Yan, Liang-Jun, Allen, Daniel C

“…Cadmium is a nonessential metal that has heavily polluted the environment due to human activities. It can be absorbed into the human body via the…”
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The Nicotinamide/Streptozotocin Rodent Model of Type 2 Diabetes: Renal Pathophysiology and Redox Imbalance Features by Yan, Liang-Jun

“…Diabetic nephropathy (DN) is a common complication of diabetes mellitus. While there has been a great advance in our understanding of the pathogenesis of DN,…”
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Renal-Protective Roles of Lipoic Acid in Kidney Disease by Kamt, Sulin F, Liu, Jiankang, Yan, Liang-Jun

“…The kidney is a crucial organ that eliminates metabolic waste and reabsorbs nutritious elements. It also participates in the regulation of blood pressure,…”
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Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity by Wu, Jinzi, Yan, Liang-Jun

“…Chronic hyperglycemia and the corresponding glucotoxicity are the main pathogenic mechanisms of diabetes and its complications. Streptozotocin (STZ)-induced…”
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Role and Possible Mechanisms of Sirt1 in Depression by Yan, Liang-Jun, Zhao, Xin, Zhang, Hongmei, Li, Jianguo, Lu, Guofang, Yang, Xiaorong

“…Depression is a common, devastating illness. Due to complicated causes and limited treatments, depression is still a major problem that plagues the world…”
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NADH/NAD+ Redox Imbalance and Diabetic Kidney Disease by Yan, Liang-Jun

“…Diabetic kidney disease (DKD) is a common and severe complication of diabetes mellitus. If left untreated, DKD can advance to end stage renal disease that…”
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Sources and implications of NADH/NAD(+) redox imbalance in diabetes and its complications by Wu, Jinzi, Jin, Zhen, Zheng, Hong, Yan, Liang-Jun

“…NAD(+) is a fundamental molecule in metabolism and redox signaling. In diabetes and its complications, the balance between NADH and NAD(+) can be severely…”
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Long-term intermittent fasting improves neurological function by promoting angiogenesis after cerebral ischemia via growth differentiation factor 11 signaling activation by Liu, Zhao, Liu, Mengjie, Jia, Gongwei, Li, Jiani, Niu, Lingchuan, Zhang, Huiji, Qi, Yunwen, Sun, Houchao, Yan, Liang-Jun, Ma, Jingxi

“…Intermittent fasting (IF), an alternative to caloric restriction, is a form of time restricted eating. IF conditioning has been suggested to have…”
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Redox imbalance and mitochondrial abnormalities in the diabetic lung by Wu, Jinzi, Jin, Zhen, Yan, Liang-Jun

“…Although the lung is one of the least studied organs in diabetes, increasing evidence indicates that it is an inevitable target of diabetic complications…”
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Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease by Yan, Liang-Jun

“…The kidneys carry out fundamental life-sustaining functions by removing waste substances, controlling salt and water balance, retaining substances vital to the…”
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Neuroprotective actions of methylene blue and its derivatives by Poteet, Ethan, Winters, Ali, Yan, Liang-Jun, Shufelt, Kyle, Green, Kayla N, Simpkins, James W, Wen, Yi, Yang, Shao-Hua

“…Methylene blue (MB), the first lead chemical structure of phenothiazine and other derivatives, is commonly used in diagnostic procedures and as a treatment for…”
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Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity by Luo, Xiaoting, Wu, Jinzi, Jing, Siqun, Yan, Liang-Jun

“…Diabetes and its complications are caused by chronic glucotoxicity driven by persistent hyperglycemia. In this article, we review the mechanisms of diabetic…”
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Roles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance in β Cell Function and Dysfunction by Luo, Xiaoting, Yan, Liang-Jun, Li, Rongrong

“…Pancreatic β cells not only use glucose as an energy source, but also sense blood glucose levels for insulin secretion. While pyruvate and NADH metabolic…”
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Cisplatin-Induced Kidney Toxicity: Potential Roles of Major NAD+-Dependent Enzymes and Plant-Derived Natural Products by Iskander, Amany, Yan, Liang-Jun

“…Cisplatin is an FDA approved anti-cancer drug that is widely used for the treatment of a variety of solid tumors. However, the severe adverse effects of…”
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Activation of mTOR: a culprit of Alzheimer's disease? by Cai, Zhiyou, Chen, Guanghui, He, Wenbo, Xiao, Ming, Yan, Liang-Jun

“…Alzheimer's disease (AD) is characterized by cognitive impairment in clinical presentation, and by β-amyloid (Aβ) production and the hyper-phosphorylation of…”
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Protein Redox Modification as a Cellular Defense Mechanism against Tissue Ischemic Injury by Yan, Liang-Jun

“…Protein oxidative or redox modifications induced by reactive oxygen species (ROS) or reactive nitrogen species (RNS) not only can impair protein function, but…”
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