Search Results - "Yan, Kelley S"

Wnt pathway regulation of intestinal stem cells by Mah, Amanda T., Yan, Kelley S., Kuo, Calvin J.

“…Wnt signalling is involved in multiple aspects of embryonic development and adult tissue homeostasis, notably via controlling cellular proliferation and…”
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Interfollicular Epidermal Stem Cells Self-Renew via Autocrine Wnt Signaling by Lim, Xinhong, Tan, Si Hui, Koh, Winston Lian Chye, Chau, Rosanna Man Wah, Yan, Kelley S., Kuo, Calvin J., van Amerongen, Renée, Klein, Allon Moshe, Nusse, Roel

“…The skin is a classical example of a tissue maintained by stem cells. However, the identity of the stem cells that maintain the interfollicular epidermis and…”
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Identification and Specification of the Mouse Skeletal Stem Cell by Chan, Charles K.F., Seo, Eun Young, Chen, James Y., Lo, David, McArdle, Adrian, Sinha, Rahul, Tevlin, Ruth, Seita, Jun, Vincent-Tompkins, Justin, Wearda, Taylor, Lu, Wan-Jin, Senarath-Yapa, Kshemendra, Chung, Michael T., Marecic, Owen, Tran, Misha, Yan, Kelley S., Upton, Rosalynd, Walmsley, Graham G., Lee, Andrew S., Sahoo, Debashis, Kuo, Calvin J., Weissman, Irving L., Longaker, Michael T.

“…How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage, and stromal development from a population of highly pure, postnatal…”
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intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations by Yan, Kelley S, Chia, Luis A, Li, Xingnan, Ootani, Akifumi, Su, James, Lee, Josephine Y, Su, Nan, Luo, Yuling, Heilshorn, Sarah C, Amieva, Manuel R, Sangiorgi, Eugenio, Capecchi, Mario R, Kuo, Calvin J

“…The small intestine epithelium undergoes rapid and continuous regeneration supported by crypt intestinal stem cells (ISCs). Bmi1 and Lgr5 have been…”
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Restriction of intestinal stem cell expansion and the regenerative response by YAP by Barry, Evan R., Morikawa, Teppei, Butler, Brian L., Shrestha, Kriti, de la Rosa, Rosemarie, Yan, Kelley S., Fuchs, Charles S., Magness, Scott T., Smits, Ron, Ogino, Shuji, Kuo, Calvin J., Camargo, Fernando D.

“…YAP has previously been identified as an oncogene that promotes cell growth, but now it is shown to restrict stem cell expansion during regeneration in the…”
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Dclk1-expressing tuft cells: critical modulators of the intestinal niche? by Middelhoff, Moritz, Westphalen, C Benedikt, Hayakawa, Yoku, Yan, Kelley S, Gershon, Michael D, Wang, Timothy C, Quante, Michael

“…-expressing tuft cells constitute a unique intestinal epithelial lineage that is distinct from enterocytes, Paneth cells, goblet cells, and enteroendocrine…”
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R-SPONDIN2+ mesenchymal cells form the bud tip progenitor niche during human lung development by Hein, Renee F.C., Wu, Joshua H., Holloway, Emily M., Frum, Tristan, Conchola, Ansley S., Tsai, Yu-Hwai, Wu, Angeline, Fine, Alexis S., Miller, Alyssa J., Szenker-Ravi, Emmanuelle, Yan, Kelley S., Kuo, Calvin J., Glass, Ian, Reversade, Bruno, Spence, Jason R.

“…The human respiratory epithelium is derived from a progenitor cell in the distal buds of the developing lung. These “bud tip progenitors” are regulated by…”
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Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche by Middelhoff, Moritz, Nienhüser, Henrik, Valenti, Giovanni, Maurer, H. Carlo, Hayakawa, Yoku, Takahashi, Ryota, Kim, Woosook, Jiang, Zhengyu, Malagola, Ermanno, Cuti, Krystle, Tailor, Yagnesh, Zamechek, Leah B., Renz, Bernhard W., Quante, Michael, Yan, Kelley S., Wang, Timothy C.

“…The enteric neurotransmitter acetylcholine governs important intestinal epithelial secretory and immune functions through its actions on epithelial muscarinic…”
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BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice by Hayakawa, Yoku, Tsuboi, Mayo, Asfaha, Samuel, Kinoshita, Hiroto, Niikura, Ryota, Konishi, Mitsuru, Hata, Masahiro, Oya, Yukiko, Kim, Woosook, Middelhoff, Moritz, Hikiba, Yohko, Higashijima, Naoko, Ihara, Sozaburo, Ushiku, Tetsuo, Fukayama, Masashi, Tailor, Yagnesh, Hirata, Yoshihiro, Guha, Chandan, Yan, Kelley S., Koike, Kazuhiko, Wang, Timothy C.

“…The intestinal epithelium is maintained by long-lived intestinal stem cells (ISCs) that reside near the crypt base. Above the ISC zone, there are short-lived…”
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Ascl2 Reinforces Intestinal Stem Cell Identity by Yan, Kelley S., Kuo, Calvin J.

“…Ascl2 is a Wnt-responsive master transcription factor that controls the Lgr5+ intestinal stem cell gene expression program. Now in Cell Stem Cell, Schuijers…”
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3D Organoids: An Untapped Platform for Studying Host-Microbiome Interactions in Esophageal Cancers by Flashner, Samuel, Yan, Kelley S, Nakagawa, Hiroshi

“…The microbiome is an emerging key co-factor in the development of esophageal cancer, the sixth leading cause of cancer death worldwide. However, there is a…”
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Structure and conserved RNA binding of the PAZ domain by Zhou, Ming-Ming, Yan, Kelley S, Yan, Sherry, Farooq, Amjad, Han, Arnold, Zeng, Lei

“…The discovery of RNA-mediated gene-silencing pathways, including RNA interference, highlights a fundamental role of short RNAs in eukaryotic gene regulation…”
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Multiplexed single-cell analysis reveals prognostic and nonprognostic T cell types in human colorectal cancer by Masuda, Kazuya, Kornberg, Adam, Miller, Jonathan, Lin, Sijie, Suek, Nathan, Botella, Theo, Secener, Kerim A, Bacarella, Alyssa M, Cheng, Liang, Ingham, Matthew, Rosario, Vilma, Al-Mazrou, Ahmed M, Lee-Kong, Steven A, Kiran, Ravi P, Stoeckius, Marlon, Smibert, Peter, Del Portillo, Armando, Oberstein, Paul E, Sims, Peter A, Yan, Kelley S, Han, Arnold

“…Clinical outcomes in colorectal cancer (CRC) correlate with T cell infiltrates, but the specific contributions of heterogenous T cell types remain unclear. To…”
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FGF2 promotes the expansion of parietal mesothelial progenitor pools and inhibits BMP4-mediated smooth muscle cell differentiation by Hwang, Youngmin, Shimamura, Yuko, Tanaka, Junichi, Miura, Akihiro, Sawada, Anri, Sarmah, Hemanta, Shimizu, Dai, Kondo, Yuri, Lee, Hyeonjeong, Martini, Francesca, Ninish, Zurab, Yan, Kelley S, Yamada, Kazuhiko, Mori, Munemasa

“…Mesothelial cells, in the outermost layer of internal organs, are essential for both organ development and homeostasis. Although the parietal mesothelial cell…”
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Insulin-like Growth Factor-1 and mTORC1 Signaling Promote the Intestinal Regenerative Response After Irradiation Injury by Bohin, Natacha, McGowan, Kevin P., Keeley, Theresa M., Carlson, Elizabeth A., Yan, Kelley S., Samuelson, Linda C.

“…Intestinal crypts have a remarkable capacity to regenerate after injury from loss of crypt base columnar (CBC) stem cells. After injury, facultative stem cells…”
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Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease by Kornberg, Adam, Botella, Theo, Moon, Christine S, Rao, Samhita, Gelbs, Jared, Cheng, Liang, Miller, Jonathan, Bacarella, Alyssa M, García-Vilas, Javier A, Vargas, Justin, Yu, Xuechen, Krupska, Izabela, Bush, Erin, Garcia-Carrasquillo, Reuben, Lebwohl, Benjamin, Krishnareddy, Suneeta, Lewis, Suzanne, Green, Peter H R, Bhagat, Govind, Yan, Kelley S, Han, Arnold

“…Celiac disease (CD) is an autoimmune disease in which intestinal inflammation is induced by dietary gluten. The means through which gluten-specific CD4 T cell…”
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COVID-19 Gastrointestinal Symptoms and Attenuation of the Immune Response to SARS-CoV-2 by Miller, Jonathan, Yan, Kelley S.

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Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling by Janda, Claudia Y., Dang, Luke T., You, Changjiang, Chang, Junlei, de Lau, Wim, Zhong, Zhendong A., Yan, Kelley S., Marecic, Owen, Siepe, Dirk, Li, Xingnan, Moody, James D., Williams, Bart O., Clevers, Hans, Piehler, Jacob, Baker, David, Kuo, Calvin J., Garcia, K. Christopher

“…The authors describe water-soluble surrogate Wnt agonists, with specificity towards some frizzled (FZD) receptors, which can maintain human intestinal organoid…”
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Cellular origins and lineage relationships of the intestinal epithelium by Capdevila, Claudia, Trifas, Maria, Miller, Jonathan, Anderson, Troy, Sims, Peter A, Yan, Kelley S

“…Knowledge of the development and hierarchical organization of tissues is key to understanding how they are perturbed in injury and disease, as well as how they…”
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Engineering of three-dimensional microenvironments to promote contractile behavior in primary intestinal organoids by DiMarco, Rebecca L., Su, James, Yan, Kelley S., Dewi, Ruby, Kuo, Calvin J., Heilshorn, Sarah C.

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