Search Results - "Yan, Kelley"

Wnt pathway regulation of intestinal stem cells by Mah, Amanda T., Yan, Kelley S., Kuo, Calvin J.

“…Wnt signalling is involved in multiple aspects of embryonic development and adult tissue homeostasis, notably via controlling cellular proliferation and…”
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Identification and Specification of the Mouse Skeletal Stem Cell by Chan, Charles K.F., Seo, Eun Young, Chen, James Y., Lo, David, McArdle, Adrian, Sinha, Rahul, Tevlin, Ruth, Seita, Jun, Vincent-Tompkins, Justin, Wearda, Taylor, Lu, Wan-Jin, Senarath-Yapa, Kshemendra, Chung, Michael T., Marecic, Owen, Tran, Misha, Yan, Kelley S., Upton, Rosalynd, Walmsley, Graham G., Lee, Andrew S., Sahoo, Debashis, Kuo, Calvin J., Weissman, Irving L., Longaker, Michael T.

“…How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage, and stromal development from a population of highly pure, postnatal…”
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COVID-19 Gastrointestinal Symptoms and Attenuation of the Immune Response to SARS-CoV-2 by Miller, Jonathan, Yan, Kelley S.

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Interfollicular Epidermal Stem Cells Self-Renew via Autocrine Wnt Signaling by Lim, Xinhong, Tan, Si Hui, Koh, Winston Lian Chye, Chau, Rosanna Man Wah, Yan, Kelley S., Kuo, Calvin J., van Amerongen, Renée, Klein, Allon Moshe, Nusse, Roel

“…The skin is a classical example of a tissue maintained by stem cells. However, the identity of the stem cells that maintain the interfollicular epidermis and…”
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intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations by Yan, Kelley S, Chia, Luis A, Li, Xingnan, Ootani, Akifumi, Su, James, Lee, Josephine Y, Su, Nan, Luo, Yuling, Heilshorn, Sarah C, Amieva, Manuel R, Sangiorgi, Eugenio, Capecchi, Mario R, Kuo, Calvin J

“…The small intestine epithelium undergoes rapid and continuous regeneration supported by crypt intestinal stem cells (ISCs). Bmi1 and Lgr5 have been…”
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Restriction of intestinal stem cell expansion and the regenerative response by YAP by Barry, Evan R., Morikawa, Teppei, Butler, Brian L., Shrestha, Kriti, de la Rosa, Rosemarie, Yan, Kelley S., Fuchs, Charles S., Magness, Scott T., Smits, Ron, Ogino, Shuji, Kuo, Calvin J., Camargo, Fernando D.

“…YAP has previously been identified as an oncogene that promotes cell growth, but now it is shown to restrict stem cell expansion during regeneration in the…”
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Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling by Janda, Claudia Y., Dang, Luke T., You, Changjiang, Chang, Junlei, de Lau, Wim, Zhong, Zhendong A., Yan, Kelley S., Marecic, Owen, Siepe, Dirk, Li, Xingnan, Moody, James D., Williams, Bart O., Clevers, Hans, Piehler, Jacob, Baker, David, Kuo, Calvin J., Garcia, K. Christopher

“…The authors describe water-soluble surrogate Wnt agonists, with specificity towards some frizzled (FZD) receptors, which can maintain human intestinal organoid…”
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Dclk1-expressing tuft cells: critical modulators of the intestinal niche? by Middelhoff, Moritz, Westphalen, C Benedikt, Hayakawa, Yoku, Yan, Kelley S, Gershon, Michael D, Wang, Timothy C, Quante, Michael

“…-expressing tuft cells constitute a unique intestinal epithelial lineage that is distinct from enterocytes, Paneth cells, goblet cells, and enteroendocrine…”
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Cellular origins and lineage relationships of the intestinal epithelium by Capdevila, Claudia, Trifas, Maria, Miller, Jonathan, Anderson, Troy, Sims, Peter A, Yan, Kelley S

“…Knowledge of the development and hierarchical organization of tissues is key to understanding how they are perturbed in injury and disease, as well as how they…”
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Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal by Yan, Kelley S., Janda, Claudia Y., Chang, Junlei, Zheng, Grace X. Y., Larkin, Kathryn A., Luca, Vincent C., Chia, Luis A., Mah, Amanda T., Han, Arnold, Terry, Jessica M., Ootani, Akifumi, Roelf, Kelly, Lee, Mark, Yuan, Jenny, Li, Xiao, Bolen, Christopher R., Wilhelmy, Julie, Davies, Paige S., Ueno, Hiroo, von Furstenberg, Richard J., Belgrader, Phillip, Ziraldo, Solongo B., Ordonez, Heather, Henning, Susan J., Wong, Melissa H., Snyder, Michael P., Weissman, Irving L., Hsueh, Aaron J., Mikkelsen, Tarjei S., Garcia, K. Christopher, Kuo, Calvin J.

“…R-spondin and Wnt ligand families act non-redundantly and cooperatively within the same molecular pathway in the intestinal stem-cell niche to maintain…”
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R-SPONDIN2+ mesenchymal cells form the bud tip progenitor niche during human lung development by Hein, Renee F.C., Wu, Joshua H., Holloway, Emily M., Frum, Tristan, Conchola, Ansley S., Tsai, Yu-Hwai, Wu, Angeline, Fine, Alexis S., Miller, Alyssa J., Szenker-Ravi, Emmanuelle, Yan, Kelley S., Kuo, Calvin J., Glass, Ian, Reversade, Bruno, Spence, Jason R.

“…The human respiratory epithelium is derived from a progenitor cell in the distal buds of the developing lung. These “bud tip progenitors” are regulated by…”
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Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity by Yan, Kelley S., Gevaert, Olivier, Zheng, Grace X.Y., Anchang, Benedict, Probert, Christopher S., Larkin, Kathryn A., Davies, Paige S., Cheng, Zhuan-fen, Kaddis, John S., Han, Arnold, Roelf, Kelly, Calderon, Ruben I., Cynn, Esther, Hu, Xiaoyi, Mandleywala, Komal, Wilhelmy, Julie, Grimes, Sue M., Corney, David C., Boutet, Stéphane C., Terry, Jessica M., Belgrader, Phillip, Ziraldo, Solongo B., Mikkelsen, Tarjei S., Wang, Fengchao, von Furstenberg, Richard J., Smith, Nicholas R., Chandrakesan, Parthasarathy, May, Randal, Chrissy, Mary Ann S., Jain, Rajan, Cartwright, Christine A., Niland, Joyce C., Hong, Young-Kwon, Carrington, Jill, Breault, David T., Epstein, Jonathan, Houchen, Courtney W., Lynch, John P., Martin, Martin G., Plevritis, Sylvia K., Curtis, Christina, Ji, Hanlee P., Li, Linheng, Henning, Susan J., Wong, Melissa H., Kuo, Calvin J.

“…Several cell populations have been reported to possess intestinal stem cell (ISC) activity during homeostasis and injury-induced regeneration. Here, we…”
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Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche by Middelhoff, Moritz, Nienhüser, Henrik, Valenti, Giovanni, Maurer, H. Carlo, Hayakawa, Yoku, Takahashi, Ryota, Kim, Woosook, Jiang, Zhengyu, Malagola, Ermanno, Cuti, Krystle, Tailor, Yagnesh, Zamechek, Leah B., Renz, Bernhard W., Quante, Michael, Yan, Kelley S., Wang, Timothy C.

“…The enteric neurotransmitter acetylcholine governs important intestinal epithelial secretory and immune functions through its actions on epithelial muscarinic…”
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Intestinal Crypts Assume the Fetal Position in Response to Injury by Pont, Adam R., Yan, Kelley S.

“…Distinct stem/progenitor cells generate intestinal epithelium during fetal and postnatal life. In a recent issue of Nature, Nusse and Savage et al. use…”
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BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice by Hayakawa, Yoku, Tsuboi, Mayo, Asfaha, Samuel, Kinoshita, Hiroto, Niikura, Ryota, Konishi, Mitsuru, Hata, Masahiro, Oya, Yukiko, Kim, Woosook, Middelhoff, Moritz, Hikiba, Yohko, Higashijima, Naoko, Ihara, Sozaburo, Ushiku, Tetsuo, Fukayama, Masashi, Tailor, Yagnesh, Hirata, Yoshihiro, Guha, Chandan, Yan, Kelley S., Koike, Kazuhiko, Wang, Timothy C.

“…The intestinal epithelium is maintained by long-lived intestinal stem cells (ISCs) that reside near the crypt base. Above the ISC zone, there are short-lived…”
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Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells by Capdevila, Claudia, Miller, Jonathan, Cheng, Liang, Kornberg, Adam, George, Joel J, Lee, Hyeonjeong, Botella, Theo, Moon, Christine S, Murray, John W, Lam, Stephanie, Calderon, Ruben I, Malagola, Ermanno, Whelan, Gary, Lin, Chyuan-Sheng, Han, Arnold, Wang, Timothy C, Sims, Peter A, Yan, Kelley S

“…In the prevailing model, Lgr5+ cells are the only intestinal stem cells (ISCs) that sustain homeostatic epithelial regeneration by upward migration of progeny…”
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Ascl2 Reinforces Intestinal Stem Cell Identity by Yan, Kelley S., Kuo, Calvin J.

“…Ascl2 is a Wnt-responsive master transcription factor that controls the Lgr5+ intestinal stem cell gene expression program. Now in Cell Stem Cell, Schuijers…”
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Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury by Malagola, Ermanno, Vasciaveo, Alessandro, Ochiai, Yosuke, Kim, Woosook, Zheng, Biyun, Zanella, Luca, Wang, Alexander L E, Middelhoff, Moritz, Nienhüser, Henrik, Deng, Lu, Wu, Feijing, Waterbury, Quin T, Belin, Bryana, LaBella, Jonathan, Zamechek, Leah B, Wong, Melissa H, Li, Linheng, Guha, Chandan, Cheng, Chia-Wei, Yan, Kelley S, Califano, Andrea, Wang, Timothy C

“…The currently accepted intestinal epithelial cell organization model proposes that Lgr5 crypt-base columnar (CBC) cells represent the sole intestinal stem cell…”
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3D Organoids: An Untapped Platform for Studying Host-Microbiome Interactions in Esophageal Cancers by Flashner, Samuel, Yan, Kelley S, Nakagawa, Hiroshi

“…The microbiome is an emerging key co-factor in the development of esophageal cancer, the sixth leading cause of cancer death worldwide. However, there is a…”
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Single-Cell Studies of Intestinal Stem Cell Heterogeneity During Homeostasis and Regeneration by Norkin, Maxim, Capdevila, Claudia, Calderon, Ruben I, Su, Tianhong, Trifas, Maria, Ordóñez-Morán, Paloma, Yan, Kelley S

“…Single-cell RNA-sequencing (scRNA-seq) provides a unique opportunity to study heterogeneous cell populations within tissues, including the intestinal…”
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