Search Results - "Yan, Hong‐Lin"
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1
Modular Construction of Heterobiaryl Atropisomers and Axially Chiral Styrenes via All‐Carbon Tetrasubstituted VQMs
Published in Angewandte Chemie International Edition (04-10-2022)“…Here we report a new type of chiral all‐carbon tetrasubstituted VQMs generated via chiral phosphoric acids catalyzed nucleophilic addition of…”
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2
Where are the new herbicides?
Published in Pest management science (01-06-2021)“…Herbicide resistance has become one of the foremost problems in crop production worldwide. New herbicides are required to manage weeds that have evolved…”
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3
Pulmonary pathology of early‐phase COVID‐19 pneumonia in a patient with a benign lung lesion
Published in Histopathology (01-11-2020)“…Aims An ongoing outbreak of 2019 novel coronavirus (CoV) disease (COVID‐19), caused by severe acute respiratory syndrome (SARS) CoV‐2, has been spreading in…”
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4
Molecular insights into the mechanism of 4‐hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X‐ray crystallography and computational simulations
Published in The FEBS journal (01-03-2019)“…Slow‐binding inhibitors with long residence time on the target often display superior efficacy in vivo. Rationally designing inhibitors with low off‐target…”
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5
Naphthoquinones: A continuing source for discovery of therapeutic antineoplastic agents
Published in Chemical biology & drug design (01-03-2018)“…Naturally occurring naphthoquinones, usually in forms of botanical extracts, have been implicated with human life since ancient time, far earlier than their…”
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6
Two 2D Polyoxometalate‐Based Metal‐Organic Complexes Constructed from a New Flexible N‐Donor Ligand with High Capacitance Performances and Low Detection Limits of Cr(VI)
Published in European journal of inorganic chemistry (09-02-2023)“…By designing and using a new flexible bis(pyrimidine)‐bis(amide) ligand H2L [H2L=N,N′‐bis(4‐pyrimidinecarboxamido)‐1,3‐propane], two new polyoxometalate…”
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7
Effects of fine particulate matter (PM2.5) on ovarian function and embryo quality in mice
Published in Environment international (01-02-2020)“…[Display omitted] •PM2.5 adversely affect health, however, little is known on female reproduction.•The work study the effects of PM2.5 on ovarian function and…”
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8
Design, synthesis and herbicidal activity of novel quinazoline‐2,4‐diones as 4‐hydroxyphenylpyruvate dioxygenase inhibitors
Published in Pest management science (01-08-2015)“…BACKGROUND: 4‐Hydroxyphenylpyruvate dioxygenase (HPPD) (EC 1.13.11.27) has been identified as one of the most promising target sites for herbicide discovery…”
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9
Three Functionalized Zinc(II)/Cobalt(II) Coordination Complexes Demonstrating Fluorescent Sensing Activities towards Fe3+ Ions and Photocatalytic Selectivity for Organic Dyes
Published in Zeitschrift für anorganische und allgemeine Chemie (1950) (30-06-2020)“…Three new zinc(II)/cobalt(II) coordination complexes [Zn(HBTB)(L)0.5] (1), [Zn(HCPPA)(L)] (2), and [Co(HCPPA)(L)]·2H2O (3) [H3BTB =…”
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10
Co‐based coordination polymer‐derived carbon nanotubes: Preparation, post‐processing and application in dye adsorption
Published in Zeitschrift für anorganische und allgemeine Chemie (1950) (10-05-2021)“…Post‐processing methods have been widely reported as an effective method to purify and functionalize the surface of carbon nanotubes (CNTs). We used a new…”
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11
Design of an HPPD fluorescent probe and visualization of plant responses to abiotic stress
Published in Advanced Agrochem (01-09-2022)“…The upregulation of 4-hydroxyphenylpyruvate dioxygenase (HPPD) can protect plants from adverse abiotic stress. Therefore, studying the changes of HPPD under…”
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12
Effects of quercetin on diabetic retinopathy and its association with NLRP3 inflammasome and autophagy
Published in International journal of ophthalmology (18-01-2021)“…To investigate the effects of quercetin on diabetic retinopathy (DR) and its association with nucleotide-binding oligomerization domain-like receptors 3…”
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13
Identification of new shikonin derivatives as STAT3 inhibitors
Published in Biochemical pharmacology (15-12-2017)“…Identification of new potent STAT3 inhibitors based on the interaction model of natural product shikonin (A), the lead compound (B), and its optimization (C)…”
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14
Identification of New Shikonin Derivatives as Antitumor Agents Targeting STAT3 SH2 Domain
Published in Scientific reports (06-06-2017)“…Signal transducer and activator of transcription 3 (STAT3) is hyper-activated in diversiform human tumors and has been validated as an attractive therapeutic…”
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15
The effects of graphene quantum dots on the maturation of mouse oocytes and development of offspring
Published in Journal of cellular physiology (01-08-2019)“…Recently, graphene nanomaterials have attracted tremendous attention and have been utilized in various fields because of their excellent mechanical, thermal,…”
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16
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo
Published in Chinese medicine (10-03-2020)“…Tamoxifen (TAM) is a cell type-specific anti-estrogen and is applied to improve the survival of patients with estrogen receptor positive (ER +) breast cancer…”
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17
Crystal Structure of 4-Hydroxyphenylpyruvate Dioxygenase in Complex with Substrate Reveals a New Starting Point for Herbicide Discovery
Published in Research (Washington) (01-01-2019)“…4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a promising target for drug and pesticide discovery. The unknown binding mode of substrate is still a big…”
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18
Pachymic acid protects oocyte by improving the ovarian microenvironment in polycystic ovary syndrome mice
Published in Biology of reproduction (01-11-2020)“…Women with polycystic ovary syndrome (PCOS) are characterized by endocrine disorders accompanied by a decline in oocyte quality. In this study, we generated a…”
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19
Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules
Published in Advanced Agrochem (01-12-2022)“…4-Hydrophenylpyruvate dioxygenase (HPPD), a key enzyme involved in tyrosine catabolism, has long been considered a promising target for herbicides and drugs…”
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20
Assembly and shifts of the bacterial rhizobiome of field grown transgenic maize line carrying mcry1Ab and mcry2Ab genes at different developmental stages
Published in Plant growth regulation (01-05-2020)“…Assessing the effects of transgenic crops on rhizobacterial communities has catalyzed numerous studies in the recent past decades. To address further to this…”
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