Search Results - "Yan, Hai"
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Molecularly Engineered Macrophage‐Derived Exosomes with Inflammation Tropism and Intrinsic Heme Biosynthesis for Atherosclerosis Treatment
Published in Angewandte Chemie International Edition (02-03-2020)“…Atherosclerosis (AS) is a major contributor to cardiovascular diseases worldwide, and alleviating inflammation is a promising strategy for AS treatment. Here,…”
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Self‐Activatable Photo‐Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy
Published in Advanced materials (Weinheim) (01-02-2021)“…Extracellular vesicles (EVs) hold great potential in both disease treatment and drug delivery. However, accurate drug release from EVs, as well as the…”
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3
Responsive Exosome Nano‐bioconjugates for Synergistic Cancer Therapy
Published in Angewandte Chemie International Edition (27-01-2020)“…Exosomes hold great potential in therapeutic development. However, native exosomes usually induce insufficient effects in vivo and simply act as drug delivery…”
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The implications of IDH mutations for cancer development and therapy
Published in Nature reviews. Clinical oncology (01-10-2021)“…Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate dehydrogenase ( IDH1 and IDH2 , respectively ; collectively referred to…”
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Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta
Published in Cell research (01-08-2018)“…The placenta is crucial for a successful pregnancy and the health of both the fetus and the pregnant woman. However, how the human trophoblast lineage is…”
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6
Silver Single Atom in Carbon Nitride Catalyst for Highly Efficient Photocatalytic Hydrogen Evolution
Published in Angewandte Chemie International Edition (14-12-2020)“…Single atom catalysts (SACs) with the maximized metal atom efficiency have sparked great attention. However, it is challenging to obtain SACs with high metal…”
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Electrode–Electrolyte Interfacial Chemistry Modulation for Ultra‐High Rate Sodium‐Ion Batteries
Published in Angewandte Chemie International Edition (25-04-2022)“…Sodium‐ion batteries capable of operating at rate and temperature extremes are highly desirable, but elusive due to the dynamics and thermodynamics…”
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Egg cell-specific promoter-controlled CRISPR/Cas9 efficiently generates homozygous mutants for multiple target genes in Arabidopsis in a single generation
Published in Genome Biology (21-07-2015)“…Arabidopsis mutants produced by constitutive overexpression of the CRISPR/Cas9 genome editing system are usually mosaics in the T1 generation. In this study,…”
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Histone deacetylase 9 deficiency exaggerates uterine M2 macrophage polarization
Published in Journal of cellular and molecular medicine (01-08-2021)“…The maternal‐foetal interface is an immune‐privileged site where the semi‐allogeneic embryo is protected from attacks by the maternal immune system. Uterine…”
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Characteristics of lean oxygen combustion and dynamic microreaction process of water-soaked coal
Published in Fuel (Guildford) (15-01-2023)“…[Display omitted] •The characteristics of low temperature oxidation kinetics of water-soaked coal samples were analyzed.•Find out the migration law of…”
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Stainless steel corrosion via direct iron-to-microbe electron transfer by Geobacter species
Published in The ISME Journal (01-10-2021)“…Microbial corrosion of iron-based materials is a substantial economic problem. A mechanistic understanding is required to develop mitigation strategies, but…”
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12
Interfacial Nucleation Seeding for Electroluminescent Manipulation in Blue Perovskite Light‐Emitting Diodes
Published in Advanced functional materials (01-11-2021)“…Efficient and stable blue emission of perovskite light‐emitting diodes (PeLEDs) is a requisite toward their potential applications in full‐color displays and…”
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13
Prevalence and burden of hepatitis D virus infection in the global population: a systematic review and meta-analysis
Published in Gut (01-03-2019)“…Hepatitis D virus (HDV) is a defective virus that completes its life cycle only with hepatitis B virus (HBV). The HBV with HDV super-infection has been…”
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14
Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction
Published in Nature communications (05-12-2019)“…Enantiomerically enriched indole-containing heterocycles play a vital role in bioscience, medicine, and chemistry. As one of the most attractive subtypes of…”
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15
Viral Protein‐Pseudotyped and siRNA‐Electroporated Extracellular Vesicles for Cancer Immunotherapy
Published in Advanced functional materials (01-12-2020)“…Extracellular vesicles (EVs) have shown great potential in drug delivery, disease diagnosis, and treatment owing to their versatile native features and…”
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A Biocompatible Free Radical Nanogenerator with Real‐Time Monitoring Capability for High Performance Sequential Hypoxic Tumor Therapy
Published in Advanced functional materials (01-09-2019)“…Hypoxic microenvironment severely reduces therapeutic efficacy of oxygen‐dependent photodynamic therapy in solid tumor due to the hampered cytotoxic oxygen…”
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Formulating High‐Rate and Long‐Cycle Heterostructured Layered Oxide Cathodes by Local Chemistry and Orbital Hybridization Modulation for Sodium‐Ion Batteries
Published in Advanced materials (Weinheim) (01-08-2022)“…It is still very urgent and challenging to simultaneously develop high‐rate and long‐cycle oxide cathodes for sodium‐ion batteries (SIBs) because of the…”
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18
Nano‐Engineering Strategies for Tumor‐Specific Therapy
Published in ChemMedChem (17-05-2024)“…Nanodelivery systems (NDSs) provide promising prospects for decreasing drug doses, reducing side effects, and improving therapeutic effects. However, the…”
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Smart Tumor‐Cell‐Derived Microparticles Provide On‐Demand Photosensitizer Synthesis and Hypoxia Relief for Photodynamic Therapy
Published in Angewandte Chemie International Edition (22-11-2021)“…Positioning essential elements of photodynamic therapy (PDT) near to mitochondria can conquer the rigorous spatiotemporal limitations of reactive oxygen…”
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Overexpression of Pde4d in rat granulosa cells inhibits maturation and atresia of antral follicles to induce polycystic ovary
Published in Biochimica et biophysica acta. Molecular basis of disease (01-01-2024)“…Follicle dysplasia can cause polycystic ovary syndrome, which can lead to anovulatory infertility. This study explored gene(s) that may contribute to…”
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