Search Results - "Yan, Chaojun"

α-Ketoglutarate-dependent Enzymes in Breast Cancer and Therapeutic Implications by Xiong, Jingjing, Yan, Chaojun, Zhang, Qing, Zhang, Jing

“…Abstract α-Ketoglutarate (αKG)-dependent dioxygenases are a superfamily of enzymes that require oxygen, reduced iron, and αKG for their catalytic functions…”
Get full text

PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis by Yan, Chaojun, Gong, Longlong, Chen, Li, Xu, Meng, Abou-Hamdan, Hussein, Tang, Mingliang, Désaubry, Laurent, Song, Zhiyin

“…Mitophagy, which is a conserved cellular process for selectively removing damaged or unwanted mitochondria, is critical for mitochondrial quality control and…”
Get full text

OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development by Wu, Zhida, Zuo, Meiling, Zeng, Ling, Cui, Kaisa, Liu, Bing, Yan, Chaojun, Chen, Li, Dong, Jun, Shangguan, Fugen, Hu, Wanglai, He, He, Lu, Bin, Song, Zhiyin

“…Many cancer cells maintain enhanced aerobic glycolysis due to irreversible defective mitochondrial oxidative phosphorylation (OXPHOS). This phenomenon, known…”
Get full text

Sam50–Mic19–Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact by Tang, Junhui, Zhang, Kuan, Dong, Jun, Yan, Chaojun, Hu, Chao, Ji, Hongchao, Chen, Liangyi, Chen, Shi, Zhao, Huabin, Song, Zhiyin

“…Mitochondrial cristae are critical for efficient oxidative phosphorylation, however, how cristae architecture is precisely organized remains largely unknown…”
Get full text

Phillygenin attenuates cell apoptosis and microglia activation in cerebral ischaemia–reperfusion rats through activation of peroxisome proliferator‐activated receptor γ by Yan, Chaojun, Sun, Guangwei, Hu, Changlong, Qiu, Tao, Wang, Meng, Fan, Yongzhong

“…Ischaemic stroke is a common condition that can lead to cerebral ischaemia–reperfusion injury. Phillygenin (PHI), a natural bioactive compound derived from…”
Get full text

Mitochondrial DNA: Distribution, Mutations, and Elimination by Yan, Chaojun, Duanmu, Xiaoying, Zeng, Ling, Liu, Bing, Song, Zhiyin

“…Mitochondrion harbors its own DNA (mtDNA), which encodes many critical proteins for the assembly and activity of mitochondrial respiratory complexes. mtDNA is…”
Get full text

Loss of Sam50 in hepatocytes induces cardiolipin‐dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury by Chen, Li, Dong, Jun, Liao, Siyang, Wang, Siyou, Wu, Zhida, Zuo, Meiling, Liu, Bing, Yan, Chaojun, Chen, Yong, He, He, Meng, Qingtao, Song, Zhiyin

“…Background and Aims Sam50, a key component of the sorting and assembly machinery (SAM) complex, is also involved in bridging mitochondrial outer‐membrane and…”
Get full text

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30 by Yue, Wen, Chen, Ziheng, Liu, Haiyang, Yan, Chen, Chen, Ming, Feng, Du, Yan, Chaojun, Wu, Hao, Du, Lei, Wang, Yueying, Liu, Jinhua, Huang, Xiaohu, Xia, Laixin, Liu, Lei, Wang, Xiaohui, Jin, Haijing, Wang, Jun, Song, Zhiyin, Hao, Xiaojiang, Chen, Quan

“…Mitocbondrial fusion is a highly coordinated process that mixes and unifies the mitochondrial compartment for normal mitochondrial functions and mitochondrial…”
Get full text

A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression by Yan, Chaojun, Xiong, Jingjing, Zhou, Zirui, Li, Qifang, Gao, Chuan, Zhang, Mengyao, Yu, Liya, Li, Jinpeng, Hu, Ming-Ming, Zhang, Chen-Song, Cai, Cheguo, Zhang, Haojian, Zhang, Jing

“…N 6 -methyladenosine (m 6 A) methylation of RNA by the methyltransferase complex (MTC), with core components including METTL3–METTL14 heterodimers and Wilms’…”
Get full text

The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy by Zheng, Liangde, Shu, Wen-Jie, Li, Yu-Min, Mari, Muriel, Yan, Chaojun, Wang, Dehe, Yin, Zhao-Hong, Jiang, Wei, Zhou, Yu, Okamoto, Koji, Reggiori, Fulvio, Klionsky, Daniel J., Song, Zhiyin, Du, Hai-Ning

“…Mitophagy is a critical process that safeguards mitochondrial quality control in order to maintain proper cellular homeostasis. Although the…”
Get full text

Systematic review of the effect of cerebrospinal fluid drainage on outcomes after endovascular type B aortic dissection repair by Zheng, Huajie, Lin, Deqing, Cheng, Yongbo, Yan, Chaojun, Yu, Sanjiu, Li, Jun, Cheng, Wei

“…The aim of the present systematic review was to determine whether prophylactic use of cerebrospinal fluid drainage (CSFD) contributes to a lower rate of spinal…”
Get full text

A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress by Jiang, Weiwei, Zhang, Mengyao, Gao, Chuan, Yan, Chaojun, Gao, Ronghui, He, Ziwei, Wei, Xin, Xiong, Jingjing, Ruan, Zilun, Yang, Qian, Li, Jinpeng, Li, Qifang, Zhong, Ziyi, Zhang, Mengna, Yuan, Qianqian, Hu, Hankun, Wang, Shuang, Hu, Ming‐Ming, Cai, Cheguo, Wu, Gao‐Song, Jiang, Chao, Zhang, Ya‐Lin, Zhang, Chen‐Song, Zhang, Jing

“…Abstract Mitochondria play essential roles in cancer cell adaptation to hypoxia, but the underlying mechanisms remain elusive. Through mitochondrial proteomic…”
Get full text

FDXR drives primary and endocrine-resistant tumor cell growth in ER+ breast cancer via CPT1A-mediated fatty acid oxidation by Yan, Chaojun, Gao, Ronghui, Gao, Chuan, Hong, Kai, Cheng, Meng, Liu, Xiaojing, Zhang, Qing, Zhang, Jing

“…The majority of breast cancers (BCs) expressing estrogen receptor (ER) have shown endocrine resistance. Our previous study demonstrated that ferredoxin…”
Get full text

Laboratory Study of Integrated Wet-Towing of a Triple-Bucket Jacket Foundation for Far-Offshore Applications by Yan, Chaojun, Wang, Haijun, Guo, Yaohua, Wang, Zhen, Liu, Xiao

“…As a form of clean and low-carbon green energy, offshore wind power occupies an important position in the global energy structure. With the rapid development…”
Get full text

Case report: Multiple brain metastases of atrial myxoma: Clinical experience and literature review by Ma, Kang, Zhao, Dawei, Li, Xuegang, Duan, Haijun, Yan, Chaojun, Wang, Shi, Zeng, Lan, Xu, Kai, Lai, Ying, Chen, Beike, Mu, Ning, Yang, Chuanyan, Quan, Yulian, Li, Zhengyang, Wang, Xiaoming, Feng, Hua, Li, Fei

“…Myxoma is the most common type of benign cardiac tumor in adults, and it has a strong tendency to embolize or metastasize to distant organs. Patients with…”
Get full text

LonP1 Links Mitochondria-ER Interaction to Regulate Heart Function by Li, Yujie, Huang, Dawei, Jia, Lianqun, Shangguan, Fugen, Gong, Shiwei, Lan, Linhua, Song, Zhiyin, Xu, Juan, Yan, Chaojun, Chen, Tongke, Tan, Yin, Liu, Yongzhang, Huang, Xingxu, Suzuki, Carolyn K, Yang, Zhongzhou, Yang, Guanlin, Lu, Bin

“…Interorganelle contacts and communications are increasingly recognized to play a vital role in cellular function and homeostasis. In particular, the…”
Get full text

A new minimal invasive technique with in-situ stent-graft fenestration for type A aortic dissection by Yu, Sanjiu, Lin, Deqing, Yi, Jianguang, Zhang, Xianpu, Cheng, Yongbo, Yan, Chaojun, Zheng, Huajie, Tang, Lingfeng, Guo, Mei, He, Ping, Li, Jun, Cheng, Wei

“…Aortic surgery successfully improves the prognosis of patients with type A aortic dissection. However, total arch replacement and reconstruction remain…”
Get full text

Effect of High-Flow Nasal Cannula for Hypoxemia Following Sun's Procedure in Acute Aortic Dissection Type a Patients by Yan, ChaoJun, Zhang, Jianrong, Wu, Yi, Yao, Jie, Li, Jun, Zhang, Xianpu, Cheng, Yongbo, Liu, Xin, Yi, Jianguang, Lin, Deqin, Yu, Sanjiu, Guo, Mei, Lu, Liuhong, Cheng, Wei, He, Ping

“…Background: Patients with acute aortic dissection type A (AADA) often have hypoxemia (partial pressure of oxygen [PaO 2 ]/fraction of inspired oxygen [FiO 2 ]…”
Get full text

Technical Improvements of Difficult Tracheotomy by Fan, Yongzhong, Cai, Jundan, Yan, Chaojun

“…The aim of this study was to explore the application value of technical improvements of difficult tracheotomy. Percutaneous dilatational tracheotomy kit…”
Get full text

Ketoglutarate-dependent Enzymes in Breast Cancer and Therapeutic Implications by Xiong, Jingjing, Yan, Chaojun, Zhang, Qing, Zhang, Jing

“…[alpha]-Ketoglutarate ([alpha]KG)-dependent dioxygenases are a superfamily of enzymes that require oxygen, reduced iron, and [alpha]KG for their catalytic…”
Get full text