Search Results - "Yamazaki, Takanobu"

Effects of the combination of vibegron and imidafenacin on bladder function in urethane-anesthetized rats by Yamazaki, Takanobu, Maruyama, Itaru

“…The combination of a β3-adrenoceptor agonist and an antimuscarinic agent was revealed to be more effective than monotherapy for patients with overactive…”
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Vibegron shows high selectivity and potent agonist activity for β3-adrenoceptors, irrespective of receptor density by Yamamoto, Shota, Kusabuka, Hotaka, Matsuzawa, Akane, Maruyama, Itaru, Yamazaki, Takanobu

“…β3-Adrenoceptor (AR) agonists are used to treat patients with an overactive bladder (OAB). Clinical proof-of-concept data have been obtained for the β3-AR…”
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Imidafenacin exerts the antidiuretic effect by enhancing vasopressin-related responses in orally water-loaded rats by Yamazaki, Takanobu, Fukata, Ayako, Muraki, Yukiko

“…Imidafenacin, an antimuscarinic agent for treating overactive bladder, has an antidiuretic effect, but the detailed mechanisms of action remain unclear. The…”
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In vivo bladder selectivity of imidafenacin, a novel antimuscarinic agent, assessed by using an effectiveness index for bladder capacity in rats by Yamazaki, Takanobu, Muraki, Yukiko, Anraku, Tsuyoshi

“…Imidafenacin (KRP-197) is a novel antimuscarinic agent for overactive bladder treatment. The inhibitory effect of imidafenacin on detrusor contraction has been…”
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Vibegron shows high selectivity and potent agonist activity for [beta]3-adrenoceptors, irrespective of receptor density by Yamamoto, Shota, Kusabuka, Hotaka, Matsuzawa, Akane, Maruyama, Itaru, Yamazaki, Takanobu

“…[beta]3-Adrenoceptor (AR) agonists are used to treat patients with an overactive bladder (OAB). Clinical proof-of-concept data have been obtained for the…”
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Vibegron inhibits enhanced spontaneous contractions induced by anoxia/reoxygenation in isolated whole bladder from rats by Ikeda, Makoto, Nakada, Akihiro, Abukawa, Hayato, Yamazaki, Takanobu, Maruyama, Itaru

“…It has been recently proposed that repeated bladder ischemia/reperfusion induced by chronic pelvic ischemia may lead to detrusor overactivity, followed by…”
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Effects of vibegron, a novel β3-adrenoceptor agonist, and its combination with imidafenacin or silodosin in a rat with partial bladder outlet obstruction by Maruyama, Itaru, Yamamoto, Shota, Tsuchioka, Kumi, Yamazaki, Takanobu

“…Urgency is regarded as a core symptom of overactive bladder (OAB) and may correspond to detrusor overactivity (DO). One of the causes of OAB in men is bladder…”
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Imidafenacin has no influence on learning in nucleus basalis of Meynert-lesioned rats by Yamazaki, Takanobu, Fukata, Ayako

“…The prevalence of overactive bladder (OAB) and Alzheimer’s disease (AD) increases with age, and much attention has been paid to the risk of cognitive…”
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Effects of spinorphin and tynorphin on synaptic transmission in rat hippocampal slices by Yamazaki, Takanobu, Honda, Motoko, Yamamoto, Yukio, Hazato, Tadahiko, Ono, Hideki

“…Spinorphin has been isolated from the bovine spinal cord as an endogenous inhibitor of enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase…”
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Effects of vibegron, a novel β 3 -adrenoceptor agonist, and its combination with imidafenacin or silodosin in a rat with partial bladder outlet obstruction by Maruyama, Itaru, Yamamoto, Shota, Tsuchioka, Kumi, Yamazaki, Takanobu

“…Urgency is regarded as a core symptom of overactive bladder (OAB) and may correspond to detrusor overactivity (DO). One of the causes of OAB in men is bladder…”
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Ibudilast, a mixed PDE3/4 inhibitor, causes a selective and nitric oxide/cGMP-independent relaxation of the intracranial vertebrobasilar artery by Yamazaki, Takanobu, Anraku, Tsuyoshi, Matsuzawa, Shigeki

“…Ibudilast, a mixed phosphodiesterase (PDE) 3/4 inhibitor, is a cerebral vasodilator widely used in Japan for treating post-stroke dizziness. However, little…”
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Pharmacological Effects of Imidafenacin (KRP-197/ONO-8025), a New Bladder Selective Anti-cholinergic Agent, in Rats by Kobayashi, Fumiyoshi, Yageta, Yuichi, Yamazaki, Takanobu, Wakabayashi, Eiji, Inoue, Masako, Segawa, Mitsuru, Matsuzawa, Shigeki

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Effects of spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, on synaptic transmission in rat hippocampal slices by Yamazaki, Takanobu, Honda, Motoko, Hazato, Tadahiko, Ono, Hideki

“…Spinorphin has been isolated from the bovine spinal cord as an endogenous inhibitor of enkephalin-degrading enzymes. In this study the effects of spinorphin on…”
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QT PRODACT: A Multi-site Study of In Vitro Action Potential Assays on 21 Compounds in Isolated Guinea-Pig Papillary Muscles by Hayashi, Seiji, Kii, Yoshihide, Tabo, Mitsuyasu, Fukuda, Hitoshi, Itoh, Tetsuji, Shimosato, Takashi, Amano, Hideto, Saito, Mamoru, Morimoto, Hajime, Yamada, Kiyoshi, Kanda, Atsuhiro, Ishitsuka, Toshimasa, Yamazaki, Takanobu, Kiuchi, Yoichi, Taniguchi, Shinya, Mori, Tatsuya, Shimizu, Shigekazu, Tsurubuchi, Yuji, Yasuda, Shun-ichi, Kitani, Shin-ichi, Shimada, Chiaki, Kobayashi, Kazuo, Komeno, Masaharu, Kasai, Chieko, Hombo, Toshiyasu, Yamamoto, Keiji

“…To construct a non-clinical database for drug-induced QT interval prolongation, the electrophysiological effects of 11 positive and 10 negative compounds on…”
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QT PRODACT: Evaluation of the Potential of Compounds to Cause QT Interval Prolongation by Action Potential Assays Using Guinea-Pig Papillary Muscles by Kii, Yoshihide, Hayashi, Seiji, Tabo, Mitsuyasu, Shimosato, Takashi, Fukuda, Hitoshi, Itoh, Tetsuji, Amano, Hideto, Saito, Mamoru, Morimoto, Hajime, Yamada, Kiyoshi, Kanda, Atsuhiro, Ishitsuka, Toshimasa, Yamazaki, Takanobu, Kiuchi, Yoichi, Taniguchi, Shinya, Mori, Tatsuya, Shimizu, Shigekazu, Tsurubuchi, Yuji, Yasuda, Shun-ichi, Kitani, Shin-ichi, Shimada, Chiaki, Kobayashi, Kazuo, Komeno, Masaharu, Kasai, Chieko, Hombo, Toshiyasu, Yamamoto, Keiji

“…Certain compounds that prolong QT interval in humans have little or no effect on action-potential (AP) duration used traditionally, but they inhibit…”
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Pharmacological effects of imidafenacin (KRP-197/ONO-8025), a new bladder selective anti-cholinergic agent, in rats : Comparison of effects on urinary bladder capacity and contraction, salivary secretion and performance in the Morris water maze task by KOBAYASHI, Fumiyoshi, YAGETA, Yuichi, YAMAZAKI, Takanobu, WAKABAYASHI, Eiji, INOUE, Masako, SEGAWA, Mitsuru, MATSUZAWA, Shigeki

“…Imidafenacin (CAS 170105-16-5, KRP-197, ONO-8025) has been developed for the treatment of overactive bladder as a new anti-cholinergic with high affinities for…”
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Use-dependent inhibition by spinorphin of synaptic transmission in rat hippocampal slices by Yamazaki, Takanobu, Honda, Motoko, Yamamoto, Yukio, Hazato, Tadahiko, Ono, Hideki

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P-194 - Use-dependent inhibition by spinorphin of synaptic transmission in rat hippocampal slices by Yamazaki, Takanobu, Honda, Motoko, Yamamoto, Yukio, Hazato, Tadahiko, Ono, Hideki

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