Search Results - "Yamazaki, Mayako"

Effects of (+)-bicuculline, a GABAa receptor antagonist, on auditory steady state response in free-moving rats by Yamazaki, Mayako, Honda, Sokichi, Tamaki, Keisuke, Irie, Megumi, Mihara, Takuma

“…Auditory steady-state responses (ASSRs) are states in which the electrical activity of the brain reacts steadily to repeated auditory stimuli. They are known…”
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Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors by Chino, Ayaka, Seo, Ryushi, Amano, Yasushi, Namatame, Ichiji, Hamaguchi, Wataru, Honbou, Kazuya, Mihara, Takuma, Yamazaki, Mayako, Tomishima, Masaki, Masuda, Naoyuki

“…In this study, we report the identification of potent pyrimidoindazoles as phosphodiesterase10A (PDE10A) inhibitors by using the method of fragment-based drug…”
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Novel 5-HT5A receptor antagonists ameliorate scopolamine-induced working memory deficit in mice and reference memory impairment in aged rats by Yamazaki, Mayako, Okabe, Mayuko, Yamamoto, Noriyuki, Yarimizu, Junko, Harada, Katsuya

“…Despite the human 5-HT5A receptor being cloned in 1994, the biological function of this receptor has not been extensively characterized due to a lack of…”
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5-HT5A Receptor Antagonist ASP5736 Ameliorates Several Abnormal Behaviors in an Fmr1- Targeted Transgenic Male Rat Model of Fragile X Syndrome by Yamazaki, Mayako, Arai, Takatomo, Yarimizu, Junko, Matsumoto, Mitsuyuki

“…Abstract Background Fragile X syndrome (FXS) is a genetic condition that causes a range of developmental problems, including intellectual disability,…”
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5-H[T.sub.5A] Receptor Antagonist ASP5736 Ameliorates Several Abnormal Behaviors in an Fmr1-Targeted Transgenic Male Rat Model of Fragile X Syndrome by Yamazaki, Mayako, Arai, Takatomo, Yarimizu, Junko, Matsumoto, Mitsuyuki

“…Background: Fragile X syndrome (FXS) is a genetic condition that causes a range of developmental problems, including intellectual disability, aggressive…”
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Effects of by Yamazaki, Mayako, Honda, Sokichi, Tamaki, Keisuke, Irie, Megumi, Mihara, Takuma

“…Auditory steady-state responses (ASSRs) are states in which the electrical activity of the brain reacts steadily to repeated auditory stimuli. They are known…”
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ASP2905, a specific inhibitor of the potassium channel Kv12.2 encoded by the Kcnh3 gene, is psychoactive in mice by Takahashi, Shinji, Okamura, Ai, Yamazaki, Mayako, Ni, Keni

“…Schizophrenia is a major psychiatric disorder associated with positive and negative symptoms and cognitive impairments. In this study, we used animal models of…”
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Neurochemical and neuropharmacological characterization of ASP2905, a novel potent selective inhibitor of the potassium channel KCNH3 by Takahashi, Shinji, Inamura, Kohei, Yarimizu, Junko, Yamazaki, Mayako, Murai, Nobuhito, Ni, Keni

“…KCNH3 (BEC1) is a member of the ether-à-go-go (KCNH) family of voltage-gated K+ channels. The aim of this study was to determine the pharmacological profiles…”
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Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability by Chino, Ayaka, Masuda, Naoyuki, Amano, Yasushi, Honbou, Kazuya, Mihara, Takuma, Yamazaki, Mayako, Tomishima, Masaki

“…In this study, we report the identification of potent benzimidazoles as PDE10A inhibitors. We first identified imidazopyridine 1 as a high-throughput screening…”
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ASP5736, a novel 5-HT5A receptor antagonist, ameliorates positive symptoms and cognitive impairment in animal models of schizophrenia by Yamazaki, Mayako, Harada, Katsuya, Yamamoto, Noriyuki, Yarimizu, Junko, Okabe, Mayuko, Shimada, Takeshi, Ni, Keni, Matsuoka, Nobuya

“…Abstract We recently identified ASP5736, ( N -(diaminomethylene)-1-(3,5-difluoropyridin-4-yl)-4-fluoroisoquinoline-7-carboxamide (2 E )-but-2-enedioate), a…”
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Synthesis, SAR study, and biological evaluation of novel 2,3-dihydro-1H-imidazo[1,2-a]benzimidazole derivatives as phosphodiesterase 10A inhibitors by Chino, Ayaka, Honda, Shugo, Morita, Masataka, Yonezawa, Koichi, Hamaguchi, Wataru, Amano, Yasushi, Moriguchi, Hiroyuki, Yamazaki, Mayako, Aota, Masaki, Tomishima, Masaki, Masuda, Naoyuki

“…[Display omitted] Phosphodiesterase 10A (PDE10A) inhibitors were designed and synthesized based on the dihydro-imidazobenzimidazole scaffold. Compound 5a…”
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A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease by Harada, Katsuya, Nakato, Kazuhiro, Yarimizu, Junko, Yamazaki, Mayako, Morita, Masahiko, Takahashi, Shinji, Aota, Masaki, Saita, Kyoko, Doihara, Hitoshi, Sato, Yuichiro, Yamaji, Takayuki, Ni, Keni, Matsuoka, Nobuya

“…Hypofunction of brain N-methyl-d-aspartate (NMDA) receptors has been implicated in psychiatric disorders such as schizophrenia and Alzheimer's disease…”
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Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors by Ayaka Chino, Ryushi Seo, Yasushi Amano, Ichiji Namatame, Wataru Hamaguchi, Kazuya Honbou, Takuma Mihara, Mayako Yamazaki, Masaki Tomishima, Naoyuki Masuda

“…In this study, we report the identification of potent pyrimidoindazoles as phosphodiesterase10A (PDE10A) inhibitors by using the method of fragment-based drug…”
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Functional mechanism of ASP5736, a selective serotonin 5-HT 5A receptor antagonist with potential utility for the treatment of cognitive dysfunction in schizophrenia by Yamazaki, Mayako, Yamamoto, Noriyuki, Yarimizu, Junko, Okabe, Mayuko, Moriyama, Ai, Furutani, Masako, Marcus, Monica M, Svensson, Torgny H, Harada, Katsuya

“…The 5-HT receptor is arguably the least understood 5-HT receptor. Despite widespread expression in human and rodent brains it lacks specific ligands. Our…”
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Functional mechanism of ASP5736, a selective serotonin 5-HT5A receptor antagonist with potential utility for the treatment of cognitive dysfunction in schizophrenia by Yamazaki, Mayako, Yamamoto, Noriyuki, Yarimizu, Junko, Okabe, Mayuko, Moriyama, Ai, Furutani, Masako, Marcus, Monica M., Svensson, Torgny H., Harada, Katsuya

“…The 5-HT5A receptor is arguably the least understood 5-HT receptor. Despite widespread expression in human and rodent brains it lacks specific ligands. Our…”
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Effects of non-steroidal anti-inflammatory drugs on Aβ deposition in Aβ1–42 transgenic C. elegans by Morita, Masahiko, Osoda, Kazuhiko, Yamazaki, Mayako, Shirai, Fumiyuki, Matsuoka, Nobuya, Arakawa, Hiroyuki, Nishimura, Shintaro

“…Abstract Although epidemiological studies have shown that long-term treatment with non-steroidal anti-inflammatory drugs (NSAIDs) may protect against…”
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Effects of non-steroidal anti-inflammatory drugs on Ab deposition in Ab1-42 transgenic C. elegans by Morita, Masahiko, Osoda, Kazuhiko, Yamazaki, Mayako, Shirai, Fumiyuki, Matsuoka, Nobuya, Arakawa, Hiroyuki, Nishimura, Shintaro

“…Although epidemiological studies have shown that long-term treatment with non-steroidal anti-inflammatory drugs (NSAIDs) may protect against Alzheimer's…”
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Effects of non-steroidal anti-inflammatory drugs on Aβ deposition in Aβ 1–42 transgenic C. elegans by Morita, Masahiko, Osoda, Kazuhiko, Yamazaki, Mayako, Shirai, Fumiyuki, Matsuoka, Nobuya, Arakawa, Hiroyuki, Nishimura, Shintaro

“…Although epidemiological studies have shown that long-term treatment with non-steroidal anti-inflammatory drugs (NSAIDs) may protect against Alzheimer's…”
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Combination of a novel antidementia drug FK960 with donepezil synergistically improves memory deficits in rats by Tokita, Kenichi, Yamazaki, Shunji, Yamazaki, Mayako, Matsuoka, Nobuya, Mutoh, Seitaro

“…FK960 [ N-(4-acetyl-1-piperazinyl)- p-fluorobenzamide monohydrate] is a novel antidementia drug which has been demonstrated to have potential…”
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The Possible Role of Age-Related Increase in the Plasma Glucagon/Insulin Ratio in the Enhanced Hepatic Gluconeogenesis and Hyperglycemia in Genetically Diabetic (C57BL/KsJ-db/db) Mice by Kodama, Hiroshi, Fujita, Masataka, Yamazaki, Mayako, Yamaguchi, Isamu

“…Genetically diabetic db/db mice and their normoglycemic littermates (+/+ mice) were studied to determine plasma levels of glucose, glucagon and insulin and…”
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