Search Results - "Yamazaki, Matsumi"

Genipin exhibits neurotrophic effects through a common signaling pathway in nitric oxide synthase-expressing cells by Yamazaki, Matsumi, Chiba, Kenzo

“…We have reported previously that genipin, a natural iridoid compound, induces neuritogenesis through a nitric oxide (NO)–cyclic GMP (cGMP)–cGMP-dependent…”
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Neuroprotective Action of Genipin on Tunicamycin-Induced Cytotoxicity in Neuro2a Cells by Tanaka, Masayuki, Yamazaki, Matsumi, Chiba, Kenzo

“…Accumulation of unfolding or misfolded proteins within the lumen of the endoplasmic reticulum (ER) triggers ER stress, and sustained ER stress ultimately leads…”
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Long-acting genipin derivative protects retinal ganglion cells from oxidative stress models in vitro and in vivo through the Nrf2/antioxidant response element signaling pathway by Koriyama, Yoshiki, Chiba, Kenzo, Yamazaki, Matsumi, Suzuki, Hirokazu, ichiro Muramoto, Ken, Kato, Satoru

“…J. Neurochem. (2010) 115, 79-91. Previously, we reported that genipin, a herbal iridoid, had neuritogenic and neuroprotective actions on PC12 cells. Although…”
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Genipin Suppresses A23187-Induced Cytotoxicity in Neuro2a Cells by Yamazaki, Matsumi, Chiba, Kenzo, Yoshikawa, Chiaki

“…Genipin is an iridoid compound and an aglucon of geniposide isolated from Gardenia fructus. We have previously reported that genipin induces neurite outgrowth…”
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Requirement of retinoic acid receptor β for genipin derivative-induced optic nerve regeneration in adult rat retina by Koriyama, Yoshiki, Takagi, Yusuke, Chiba, Kenzo, Yamazaki, Matsumi, Sugitani, Kayo, Arai, Kunizo, Suzuki, Hirokazu, Kato, Satoru

“…Like other CNS neurons, mature retinal ganglion cells (RGCs) are unable to regenerate their axons after nerve injury due to a diminished intrinsic regenerative…”
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Neuritogenic Activities of 1-Alkyloxygenipins by Suzuki, Hirokazu, Yamazaki, Matsumi, Chiba, Kenzo, Uemori, Yoshio, Sawanishi, Hiroyuki

“…We designed 1-alkyloxygenipins with the aim of improving the stability of genipins based on the structural and electronic properties of genipins, and prepared…”
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Neurotoxicity of Advanced Glycation End-Products for Cultured Cortical Neurons by TAKEUCHI, MASAYOSHI, BUCALA, RICHARD, SUZUKI, TAKAKO, OHKUBO, TADATOSHI, YAMAZAKI, MATSUMI, KOIKE, TAKAO, KAMEDA, YUKIHIKO, MAKITA, ZENJI

“…The Maillard reaction that leads to the formation of advanced glycation end-products (AGEs) plays an important role in the pathogenesis of angiopathy in…”
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Fundamental role of nitric oxide in neuritogenesis of PC12h cells by Yamazaki, Matsumi, Chiba, Kenzo, Mohri, Tetsuro

“…We investigated the neuritogenic action of nitric oxide (NO)‐generating agents and their mechanisms of action in a subclone of rat pheochromocytoma, PC12h…”
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New physiological function of secoiridoids: neuritogenic activity in PC12h cells by Chiba, Kenzo, Yamazaki, Matsumi, Kikuchi, Masafumi, Kakuda, Rie, Kikuchi, Masao

“…Previously, we have reported that geniposide isolated from an extract of Gardenia fructus has neuritogenic activity in PC12h cells, a subclone of rat…”
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Activation of the mitogen‐activated protein kinase cascade through nitric oxide synthesis as a mechanism of neuritogenic effect of genipin in PC12h cells by Yamazaki, Matsumi, Chiba, Kenzo, Mohri, Tetsuro, Hatanaka, Hiroshi

“…Prominent neurite outgrowth induced by genipin, a plant‐derived iridoid, was substantially inhibited by addition of NG‐nitro‐l‐arginine methyl ester (l‐NAME),…”
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Neuro2a Cell Death Induced by 6-Hydroxydopamine is Attenuated by Genipin by Yamazaki, Matsumi, Chiba, Kenzo, Satoh, Keiko

“…We have previously reported that genipin, a natural iridoid compound, shows neuritogenic activity in cultured rat pheochromocytoma PC12h and mouse…”
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Prevention of the Neurotoxicity of the Amyloid β Protein by Genipin by YAMAZAKI, Matsumi, SAKURA, Naoki, CHIBA, Kenzo, MOHRI, Tetsuro

“…Genipin, which was shown in our previous investigation to have prominent neuritogenic activity in paraneurons such as PC12h cells, was studied to determine…”
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Effect of Polyacetylenes on the Neurite Outgrowth of Neuronal Culture Cells and Scopolamine-Induced Memory Impairment in Mice by YAMAZAKI, Matsumi, HIRAKURA, Kazuhiro, MIYAICHI, Yukinori, IMAKURA, Kimiaki, KITA, Mika, CHIBA, Kenzo, MOHRI, Tetsuro

“…Polyacetylenic alcohols and their linoleates isolated from Panax ginseng C.A. Meyer and Cirsium japonicum DC., of which the lipophilic extracts had been found…”
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Neurotrophic Effects of Genipin on Neuro2a Cells by Yamazaki, Matsumi, Chiba, Kenzo

“…We have found that genipin, a herbal iridoid compound, can induce neurite outgrowth in rat pheochromocytoma PC12h cells. In this study, we examined the…”
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Neuritogenic Effect of Natural Iridoid Compounds on PC12h Cells and Its Possible Relation to Signaling Protein Kinases by YAMAZAKI, Matsumi, CHIBA, Kenzo, MOHRI, Tetsuro

“…We examined effect of iridoid glucosides, aucubin, catalpol, geniposide and gardenoside, and their enzymic hydrolysates on neurite outgrowth of PC12h cells…”
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Characteristic Properties of Genipin as an Activator in Neuronal Nitric Oxide Synthase by Suzuki, Hirokazu, Yamazaki, Matsumi, Chiba, Kenzo, Sawanishi, Hiroyuki

“…The present investigation was undertaken to compare the structural and electronic properties of genipin with those of tetrahydrobiopterin (H4B), an essential…”
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Expression of Functional Nitric Oxide Synthase for Neuritogenesis in PC12h Cells by Yamazaki, Matsumi, Chiba, Kenzo

“…We have previously demonstrated that a natural iridoid compound, genipin, induces neurite outgrowth mediated by nitric oxide (NO) production in PC12h cells…”
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Neuritogenesis of Herbal (+)- and (−)-Syringaresinols Separated by Chiral HPLC in PC12h and Neuro2a Cells by Chiba, Kenzo, Yamazaki, Matsumi, Umegaki, Emiko, Li, Ming Run, Xu, Zhen Wen, Terada, Sumio, Taka, Michihiro, Naoi, Noriyuki, Mohri, Tetsuro

“…Syringaresinol isolated from Epimedium koreanum NAKAI and Magnolia officinalis REHD. et WILS. was subjected to optical resolution by chiral HPLC to give (+)-…”
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Detection of Genipin/Geniposide-Target Molecules by a Geniposide Overlay Method Using Anti-Geniposide Antibody by Ohkubo, Tadatoshi, Yamazaki, Matsumi, Yoshida, Akihiro

“…A geniposide overlay method for the detection of genipin/geniposide-binding proteins was attempted using a specific anti-geniposide antiserum. The specific…”
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Correlation between Neuritogenic Action of Nitric Oxide and the Rate of Nitric Oxide Production in PC12h Cells by Chiba, Kenzo, Yamazaki, Matsumi

“…To investigate the effects of the nitric oxide (NO) generating rate on neuritogenesis, we compared the neuritogenic activity of several NO donors with varying…”
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