Search Results - "Yamazaki, Hiroshi"

Species Specificity and Selection of Models for Drug Oxidations Mediated by Polymorphic Human Enzymes by Yamazaki, Hiroshi, Shimizu, Makiko

“…Many drug oxygenations are mainly mediated by polymorphic cytochromes P450 (P450s) and also by flavin-containing monooxygenases (FMOs). More than 50 years of…”
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Metabolic activation and deactivation of dietary-derived coumarin mediated by cytochrome P450 enzymes in rat and human liver preparations by Murayama, Norie, Yamazaki, Hiroshi

“…Dietary-derived coumarin is of clinical interest for its potential hepatotoxicity in humans because such toxicity is especially evident in rats. In this study,…”
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Updated in Silico Prediction Methods for Fractions Absorbed and Key Input Parameters of 355 Disparate Chemicals for Physiologically Based Pharmacokinetic Models for Time-Dependent Plasma Concentrations after Virtual Oral Doses in Humans by Adachi, Koichiro, Shimizu, Makiko, Yamazaki, Hiroshi

“…Human metabolic profiles for substances such as toxic food-derived compounds are usually allometrically extrapolated from traditionally determined in vivo rat…”
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Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes by Uno, Yasuhiro, Uehara, Shotaro, Yamazaki, Hiroshi

“…[Display omitted] Cynomolgus monkeys (Macaca fascicularis, an Old World Monkey) have been widely used as a non-human primate model in preclinical studies…”
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Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans by Uno, Yasuhiro, Uehara, Shotaro, Yamazaki, Hiroshi

“…[Display omitted] Many drug oxidations and conjugations are mediated by a variety of cytochromes P450 (P450) and non-P450 enzymes in humans and non-human…”
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Differences in Pharmacokinetics and Haematotoxicities of Aniline and Its Dimethyl Derivatives Orally Administered in Rats by Miura, Tomonori, Kamiya, Yusuke, Murayama, Norie, Shimizu, Makiko, Yamazaki, Hiroshi

“…Aniline and its dimethyl derivatives reportedly become haematotoxic after metabolic N-hydroxylation of their amino groups. The plasma concentrations of aniline…”
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Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals by Kamiya, Yusuke, Handa, Kentaro, Miura, Tomonori, Ohori, Junya, Kato, Airi, Shimizu, Makiko, Kitajima, Masato, Yamazaki, Hiroshi

“…Physiologically based pharmacokinetic (PBPK) modeling has the potential to play significant roles in estimating internal chemical exposures. The three major…”
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Regioselective hydroxylation of steroid hormones by human cytochromes P450 by Niwa, Toshiro, Murayama, Norie, Imagawa, Yurie, Yamazaki, Hiroshi

“…Abstract This article reviews in vitro metabolic activities [including Michaelis constants (Km), maximal velocities (Vmax) and Vmax/Km] and drug-steroid…”
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Human and monkey P450 metabolism for human-specific metabolite formation by Yamazaki, Hiroshi

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Drug interactions between nine antifungal agents and drugs metabolized by human cytochromes P450 by Niwa, Toshiro, Imagawa, Yurie, Yamazaki, Hiroshi

“…This article reviews in vitro metabolic and in vivo pharmacokinetic drug-drug interactions of nine antifungal agents: six azoles (fluconazole, itraconazole,…”
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Trivariate Linear Regression and Machine Learning Prediction of Possible Roles of Efflux Transporters in Estimated Intestinal Permeability Values of 301 Disparate Chemicals by Shimizu, Makiko, Hayasaka, Riku, Kamiya, Yusuke, Yamazaki, Hiroshi

“…A system for predicting apparent bidirectional permeability (Papp) across Caco-2 cells of diverse chemicals has been reported. The present study aimed to…”
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Updated in silico prediction methods for fractions absorbed and absorption rate constants of 372 disparate chemicals for use in physiologically based pharmacokinetic models for estimating internal concentrations in rats by Adachi, Koichiro, Shimizu, Makiko, Yamazaki, Hiroshi

“…Physiologically based pharmacokinetic (PBPK) modeling has the potential to estimate internal chemical exposures. Algorithms for predicting the input parameters…”
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Systematic identification and characterization of cynomolgus macaque solute carrier transporters by Uno, Yasuhiro, Yamazaki, Hiroshi

“…Cynomolgus macaques are used in preclinical studies in part because of their evolutionary closeness to humans. However, drug transporters [including solute…”
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Cloning and tissue expression of ATP-binding cassette transporters in cynomolgus macaques by Uno, Yasuhiro, Yamazaki, Hiroshi

“…Cynomolgus macaques are used in preclinical studies in part because of their evolutionary closeness to humans. However, drug transporters, including…”
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Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans by Uno, Yasuhiro, Uehara, Shotaro, Yamazaki, Hiroshi

“…[Display omitted] Cynomolgus monkeys (Macaca fascicularis, Old World Monkeys) and common marmosets (Callithrix jacchus, New World Monkeys) have been widely,…”
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Liver and Plasma Concentrations of Food Chemicals after Virtual Oral Doses Extrapolated Using in Silico Estimated Input Pharmacokinetic Parameters to Confirm Reported Liver Toxicity in Rats by Adachi, Koichiro, Nakano, Hina, Sato, Tasuku, Shimizu, Makiko, Yamazaki, Hiroshi

“…The estimation of health risks of chemical substances was historically investigated using animal studies; however, current research focuses on reducing the…”
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Roles of human cytochrome P450 1A2, 2C9, and 3A4/5 enzymes in drug oxidations mediated by metabolically inactivated human hepatocytes in previously transplanted chimeric mice by Yamazaki, Hiroshi, Uehara, Shotaro, Shimizu, Makiko, Suemizu, Hiroshi

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Novel Cytochrome P450 2C94 Functionally Metabolizes Diclofenac and Omeprazole in Dogs by Uno, Yasuhiro, Morikuni, Saho, Shiraishi, Mitsuya, Asano, Atsushi, Murayama, Norie, Yamazaki, Hiroshi

“…Cytochromes P450 (P450s or CYPs) are important drug-metabolizing enzymes. Because dogs are frequently used in drug metabolism studies, knowledge of dog CYP2C…”
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Molecular characterization of UDP-glucuronosyltransferases 3A and 8A in cynomolgus macaques by Uno, Yasuhiro, Yamazaki, Hiroshi

“…UDP-glucuronosyltransferases (UGTs) are drug-metabolizing enzymes essential for the metabolism of endogenous substrates and xenobiotics. The cynomolgus macaque…”
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Molecular and functional characterization of cytosolic sulfotransferases in cynomolgus macaque by Uno, Yasuhiro, Murayama, Norie, Yamazaki, Hiroshi

“…[Display omitted] Cytosolic sulfotransferases (SULTs), drug-metabolizing enzymes essential for the metabolism of endogenous biochemicals and foreign compounds,…”
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