Search Results - "Yamashita, Michiaki"

Identification of a Novel Selenium-containing Compound, Selenoneine, as the Predominant Chemical Form of Organic Selenium in the Blood of Bluefin Tuna by Yamashita, Yumiko, Yamashita, Michiaki

“…A novel selenium-containing compound having a selenium atom in the imidazole ring, 2-selenyl-Nα,Nα,Nα-trimethyl-l-histidine,…”
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Dietary Intake of Selenoneine Enhances Antioxidant Activity in the Muscles of the Amberjack Seriola dumerili Grown in Aquaculture by Tohfuku, Takuma, Ando, Hitoshi, Morishita, Naho, Yamashita, Michiaki, Kondo, Masakazu

“…The selenium (Se)-containing imidazole compound selenoneine (2-selenyl- N α , N α , N α -trimethyl- l -histidine) is a strong scavenger of reactive oxygen…”
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Selenoneine Ameliorates Hepatocellular Injury and Hepatic Steatosis in a Mouse Model of NAFLD by Miyata, Masaaki, Matsushita, Koki, Shindo, Ryunosuke, Shimokawa, Yutaro, Sugiura, Yoshimasa, Yamashita, Michiaki

“…Selenoneine is a novel organic selenium compound markedly found in the blood, muscles, and other tissues of fish. This study aimed to determine whether…”
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Selenoneine suppresses melanin synthesis by inhibiting tyrosinase in murine B16 melanoma cells and 3D-cultured human melanocytes by Seko, Takuya, Imamura, Shintaro, Ishihara, Kenji, Yamashita, Yumiko, Yamashita, Michiaki

“…The novel organic selenium compound, selenoneine, is found in the blood of tuna and has metal-binding activity. In this report, selenoneine displays tyrosinase…”
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De novo SOX11 mutations cause Coffin–Siris syndrome by Tsurusaki, Yoshinori, Koshimizu, Eriko, Ohashi, Hirofumi, Phadke, Shubha, Kou, Ikuyo, Shiina, Masaaki, Suzuki, Toshifumi, Okamoto, Nobuhiko, Imamura, Shintaro, Yamashita, Michiaki, Watanabe, Satoshi, Yoshiura, Koh-ichiro, Kodera, Hirofumi, Miyatake, Satoko, Nakashima, Mitsuko, Saitsu, Hirotomo, Ogata, Kazuhiro, Ikegawa, Shiro, Miyake, Noriko, Matsumoto, Naomichi

“…Coffin–Siris syndrome (CSS) is a congenital disorder characterized by growth deficiency, intellectual disability, microcephaly, characteristic facial features…”
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Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome by Miyake, Noriko, Tsukaguchi, Hiroyasu, Koshimizu, Eriko, Shono, Akemi, Matsunaga, Satoko, Shiina, Masaaki, Mimura, Yasuhiro, Imamura, Shintaro, Hirose, Tomonori, Okudela, Koji, Nozu, Kandai, Akioka, Yuko, Hattori, Motoshi, Yoshikawa, Norishige, Kitamura, Akiko, Cheong, Hae Il, Kagami, Shoji, Yamashita, Michiaki, Fujita, Atsushi, Miyatake, Satoko, Tsurusaki, Yoshinori, Nakashima, Mitsuko, Saitsu, Hirotomo, Ohashi, Kenichi, Imamoto, Naoko, Ryo, Akihide, Ogata, Kazuhiro, Iijima, Kazumoto, Matsumoto, Naomichi

“…The nuclear pore complex (NPC) is a huge protein complex embedded in the nuclear envelope. It has central functions in nucleocytoplasmic transport, nuclear…”
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The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity by Hanai, Jun-ichi, Cao, Peirang, Tanksale, Preeti, Imamura, Shintaro, Koshimizu, Eriko, Zhao, Jinghui, Kishi, Shuji, Yamashita, Michiaki, Phillips, Paul S, Sukhatme, Vikas P, Lecker, Stewart H

“…Statins inhibit HMG-CoA reductase, a key enzyme in cholesterol synthesis, and are widely used to treat hypercholesterolemia. These drugs can lead to a number…”
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Dietary Supplementation of Selenoneine-Containing Tuna Dark Muscle Extract Effectively Reduces Pathology of Experimental Colorectal Cancers in Mice by Masuda, Junko, Umemura, Chiho, Yokozawa, Miki, Yamauchi, Ken, Seko, Takuya, Yamashita, Michiaki, Yamashita, Yumiko

“…Selenoneine is an ergothioneine analog with greater antioxidant activity and is the major form of organic selenium in the blood, muscles, and other tissues of…”
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Protective Role of Cell Division Cycle 48 (CDC48) Protein against Neurodegeneration via Ubiquitin-Proteasome System Dysfunction during Zebrafish Development by Imamura, Shintaro, Yabu, Takeshi, Yamashita, Michiaki

“…Cell division cycle 48 (CDC48), a ubiquitin-dependent molecular chaperone, is thought to mediate a variety of degradative and regulatory processes and maintain…”
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Novel glycosylated mycosporine-like amino acid, 13-O-(β-galactosyl)-porphyra-334, from the edible cyanobacterium Nostoc sphaericum-protective activity on human keratinocytes from UV light by Ishihara, Kenji, Watanabe, Ryuichi, Uchida, Hajime, Suzuki, Toshiyuki, Yamashita, Michiaki, Takenaka, Hiroyuki, Nazifi, Ehsan, Matsugo, Seiichi, Yamaba, Minami, Sakamoto, Toshio

“…A UV-absorbing compound was purified and identified as a novel glycosylated mycosporine-like amino acid (MAA), 13-O-β-galactosyl-porphyra-334 (β-Gal-P334) from…”
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Distribution and Effects of Selenoneine by Ingestion of Extract from Mackerel Processing Residue in Mice by Seko, Takuya, Sato, Yoko, Kuniyoshi, Michiko, Murata, Yuko, Ishihara, Kenji, Yamashita, Yumiko, Fujiwara, Sanjuro, Ueda, Tomohiro, Yamashita, Michiaki

“…Selenoneine is an organic selenium compound contained in blood and dark muscle of fish. It has a strong antioxidative capacity and is considered useful as a…”
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Selenium content in seafood in Japan by Yamashita, Yumiko, Yamashita, Michiaki, Iida, Haruka

“…Selenium is an essential micronutrient for humans, and seafood is one of the major selenium sources, as well as red meat, grains, eggs, chicken, liver and…”
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Oocyte apoptosis during the transition from ovary-like tissue to testes during sex differentiation of juvenile zebrafish by Uchida, Daisuke, Yamashita, Michiaki, Kitano, Takeshi, Iguchi, Taisen

“…Large numbers of apoptotic early diplotene oocytes were observed during the transition from ovary-like undifferentiated gonadal tissue to testes during sex…”
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Induction of Autophagy by Amino Acid Starvation in Fish Cells by Yabu, Takeshi, Imamura, Shintaro, Mizusawa, Nanami, Touhata, Ken, Yamashita, Michiaki

“…Autophagy is well established as a starvation-induced process in yeast and mammalian cells and tissues. To elucidate the cellular mechanisms induced by…”
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Antiviral protection mechanisms mediated by ginbuna crucian carp interferon gamma isoforms 1 and 2 through two distinct interferon gamma-receptors by Yabu, Takeshi, Toda, Hideaki, Shibasaki, Yasuhiro, Araki, Kyosuke, Yamashita, Michiaki, Anzai, Hirosi, Mano, Nobuhiro, Masuhiro, Yoshikazu, Hanazawa, Shigemasa, Shiba, Hajime, Moritomo, Tadaaki, Nakanishi, Teruyuki

“…Fish genomes possess three type II interferon (IFN) genes, ifnγ1, ifnγ2 and ifnγ-related (ifnγrel). The IFNγ-dependent STAT signalling pathway found in humans…”
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Identification of Mg2+-dependent Neutral Sphingomyelinase 1 as a Mediator of Heat Stress-induced Ceramide Generation and Apoptosis by Yabu, Takeshi, Imamura, Shintaro, Yamashita, Michiaki, Okazaki, Toshiro

“…Neutral sphingomyelinases (SMases) are involved in the induction of ceramide-mediated proapoptotic signaling under heat stress conditions. Although ceramide is…”
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An aromatase inhibitor or high water temperature induce oocyte apoptosis and depletion of P450 aromatase activity in the gonads of genetic female zebrafish during sex-reversal by Uchida, Daisuke, Yamashita, Michiaki, Kitano, Takeshi, Iguchi, Taisen

“…Dietary administration of a cytochrome P450 aromatase (P450arom) inhibitor (fadrozole) in genetic female juveniles of zebrafish ( Danio rerio) was performed at…”
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A Novel Mitochondrial Sphingomyelinase in Zebrafish Cells by Yabu, Takeshi, Shimuzu, Akio, Yamashita, Michiaki

“…Sphingolipids are important signaling molecules in many biological processes, but little is known regarding their physiological roles in the mitochondrion. We…”
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Extensive apoptosis and abnormal morphogenesis in pro-caspase-3 transgenic zebrafish during development by Yamashita, Michiaki, Mizusawa, Nanami, Hojo, Misako, Yabu, Takeshi

“…The pro-apoptotic caspase-3 gene has been shown to have key functions in the execution of apoptosis (programmed cell death) in vertebrate cells. However, the…”
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Selenoneine, total selenium, and total mercury content in the muscle of fishes by Yamashita, Yumiko, Amlund, Heidi, Suzuki, Tamami, Hara, Tatsuro, Hossain, Mohammed Anwar, Yabu, Takeshi, Touhata, Ken, Yamashita, Michiaki

“…Levels of the selenium-containing imidazole compound selenoneine and overall organic selenium were measured in the muscle of fishes by speciation analysis. The…”
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