Search Results - "Yamashita, Jun K."

Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression by Uosaki, Hideki, Fukushima, Hiroyuki, Takeuchi, Ayako, Matsuoka, Satoshi, Nakatsuji, Norio, Yamanaka, Shinya, Yamashita, Jun K

“…Human embryonic and induced pluripotent stem cells (hESCs/hiPSCs) are promising cell sources for cardiac regenerative medicine. To realize hESC/hiPSC-based…”
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Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue by Kawatou, Masahide, Masumoto, Hidetoshi, Fukushima, Hiroyuki, Morinaga, Gaku, Sakata, Ryuzo, Ashihara, Takashi, Yamashita, Jun K.

“…Torsade de Pointes (TdP) is a lethal arrhythmia that is often drug-induced, thus there is an urgent need for development of models to test or predict the drug…”
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AMPK activators contribute to maintain naïve pluripotency in mouse embryonic stem cells by Liu, Yajing, Yamashita, Jun K.

“…Pluripotent stem cells retain the property to self-renew and differentiate into all cell types under defined conditions. Among mouse embryonic stem cells…”
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The pathways of pluripotent stem cells to clinical applications by Yamashita, Jun K

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Directed and Systematic Differentiation of Cardiovascular Cells From Mouse Induced Pluripotent Stem Cells by NARAZAKI, Genta, UOSAKI, Hideki, TERANISHI, Mizue, OKITA, Keisuke, KIM, Bongju, MATSUOKA, Satoshi, YAMANAKA, Shinya, YAMASHITA, Jun K

“…Induced pluripotent stem (iPS) cells are a novel stem cell population induced from mouse and human adult somatic cells through reprogramming by transduction of…”
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Specific induction and long-term maintenance of high purity ventricular cardiomyocytes from human induced pluripotent stem cells by Fukushima, Hiroyuki, Yoshioka, Miki, Kawatou, Masahide, López-Dávila, Víctor, Takeda, Masafumi, Kanda, Yasunari, Sekino, Yuko, Yoshida, Yoshinori, Yamashita, Jun K

“…Currently, cardiomyocyte (CM) differentiation methods require a purification step after CM induction to ensure the high purity of the cell population. Here we…”
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Modeling mutation-specific arrhythmogenic phenotypes in isogenic human iPSC-derived cardiac tissues by Maurissen, Thomas L., Kawatou, Masahide, López-Dávila, Víctor, Minatoya, Kenji, Yamashita, Jun K., Woltjen, Knut

“…Disease modeling using human induced pluripotent stem cells (hiPSCs) from patients with genetic disease is a powerful approach for dissecting pathophysiology…”
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Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP by Ikuno, Takeshi, Masumoto, Hidetoshi, Yamamizu, Kohei, Yoshioka, Miki, Minakata, Kenji, Ikeda, Tadashi, Sakata, Ryuzo, Yamashita, Jun K

“…Blood vessels are essential components for many tissues and organs. Thus, efficient induction of endothelial cells (ECs) from human pluripotent stem cells is a…”
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Human iPS cell-derived cardiac tissue sheets for functional restoration of infarcted porcine hearts by Ishigami, Masanosuke, Masumoto, Hidetoshi, Ikuno, Takeshi, Aoki, Takayuki, Kawatou, Masahide, Minakata, Kenji, Ikeda, Tadashi, Sakata, Ryuzo, Yamashita, Jun K, Minatoya, Kenji

“…To realize human induced pluripotent stem cell (hiPSC)-based cardiac regenerative therapy, evidence of therapeutic advantages in human-sized diseased hearts…”
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Expanding Reprogramming to Cardiovascular Progenitors by Yamashita, Jun K.

“…Methods to generate expandable cardiac progenitor populations are desirable for developing cellular therapies for heart failure and for studying cardiac…”
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Protein kinase A accelerates the rate of early stage differentiation of pluripotent stem cells by Minakawa, Tomohiro, Kanki, Yasuharu, Nakamura, Kae, Yamashita, Jun K.

“…In normal development, the rate of cell differentiation is tightly controlled and critical for normal development and stem cell differentiation. However, the…”
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The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages by Masumoto, Hidetoshi, Nakane, Takeichiro, Tinney, Joseph P., Yuan, Fangping, Ye, Fei, Kowalski, William J., Minakata, Kenji, Sakata, Ryuzo, Yamashita, Jun K., Keller, Bradley B.

“…Human induced pluripotent stem cells (hiPSCs) are a robust source for cardiac regenerative therapy due to their potential to support autologous and allogeneic…”
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Versatile extracellular vesicle-mediated information transfer: intercellular synchronization of differentiation and of cellular phenotypes, and future perspectives by Minakawa, Tomohiro, Yamashita, Jun K

“…In recent years, extracellular vesicles (EVs) have attracted significant attention as carriers in intercellular communication. The vast array of information…”
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Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation by Kanki, Yasuharu, Nakaki, Ryo, Shimamura, Teppei, Matsunaga, Taichi, Yamamizu, Kohei, Katayama, Shiori, Suehiro, Jun-Ichi, Osawa, Tsuyoshi, Aburatani, Hiroyuki, Kodama, Tatsuhiko, Wada, Youichiro, Yamashita, Jun K, Minami, Takashi

“…Although studies of the differentiation from mouse embryonic stem (ES) cells to vascular endothelial cells (ECs) provide an excellent model for investigating…”
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Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue by Nakane, Takeichiro, Masumoto, Hidetoshi, Tinney, Joseph P., Yuan, Fangping, Kowalski, William J., Ye, Fei, LeBlanc, Amanda J., Sakata, Ryuzo, Yamashita, Jun K., Keller, Bradley B.

“…The current study describes a scalable, porous large-format engineered cardiac tissue (LF-ECT) composed of human induced pluripotent stem cells (hiPSCs)…”
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eSPRESSO: topological clustering of single-cell transcriptomics data to reveal informative genes for spatio-temporal architectures of cells by Mori, Tomoya, Takase, Toshiro, Lan, Kuan-Chun, Yamane, Junko, Alev, Cantas, Kimura, Azuma, Osafune, Kenji, Yamashita, Jun K, Akutsu, Tatsuya, Kitano, Hiroaki, Fujibuchi, Wataru

“…Bioinformatics capability to analyze spatio-temporal dynamics of gene expression is essential in understanding animal development. Animal cells are spatially…”
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Sarcomere gene variants act as a genetic trigger underlying the development of left ventricular noncompaction by Takasaki, Asami, Hirono, Keiichi, Hata, Yukiko, Wang, Ce, Takeda, Masafumi, Yamashita, Jun K, Chang, Bo, Nakaoka, Hideyuki, Okabe, Mako, Miyao, Nariaki, Saito, Kazuyoshi, Ibuki, Keijiro, Ozawa, Sayaka, Sekine, Michikazu, Yoshimura, Naoki, Nishida, Naoki, Bowles, Neil E., Ichida, Fukiko

“…Background Left ventricular noncompaction (LVNC) is a primary cardiomyopathy with heterogeneous genetic origins. The aim of this study was to elucidate the…”
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ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism by Tian, Zhe, Miyata, Keishi, Kadomatsu, Tsuyoshi, Horiguchi, Haruki, Fukushima, Hiroyuki, Tohyama, Shugo, Ujihara, Yoshihiro, Okumura, Takahiro, Yamaguchi, Satoshi, Zhao, Jiabin, Endo, Motoyoshi, Morinaga, Jun, Sato, Michio, Sugizaki, Taichi, Zhu, Shunshun, Terada, Kazutoyo, Sakaguchi, Hisashi, Komohara, Yoshihiro, Takeya, Motohiro, Takeda, Naoki, Araki, Kimi, Manabe, Ichiro, Fukuda, Keiichi, Otsu, Kinya, Wada, Jun, Murohara, Toyoaki, Mohri, Satoshi, Yamashita, Jun K., Sano, Motoaki, Oike, Yuichi

“…A cardioprotective response that alters ventricular contractility or promotes cardiomyocyte enlargement occurs with increased workload in conditions such as…”
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Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A by Fujiwara, Masataka, Yan, Peishi, Otsuji, Tomomi G, Narazaki, Genta, Uosaki, Hideki, Fukushima, Hiroyuki, Kuwahara, Koichiro, Harada, Masaki, Matsuda, Hiroyuki, Matsuoka, Satoshi, Okita, Keisuke, Takahashi, Kazutoshi, Nakagawa, Masato, Ikeda, Tadashi, Sakata, Ryuzo, Mummery, Christine L, Nakatsuji, Norio, Yamanaka, Shinya, Nakao, Kazuwa, Yamashita, Jun K

“…Induced pluripotent stem cells (iPSCs) are novel stem cells derived from adult mouse and human tissues by reprogramming. Elucidation of mechanisms and…”
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Fabrication of mouse embryonic stem cell-derived layered cardiac cell sheets using a bioreactor culture system by Matsuura, Katsuhisa, Wada, Masanori, Konishi, Kanako, Sato, Michi, Iwamoto, Ushio, Sato, Yuko, Tachibana, Aki, Kikuchi, Tetsutaro, Iwamiya, Takahiro, Shimizu, Tatsuya, Yamashita, Jun K, Yamato, Masayuki, Hagiwara, Nobuhisa, Okano, Teruo

“…Bioengineered functional cardiac tissue is expected to contribute to the repair of injured heart tissue. We previously developed cardiac cell sheets using…”
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