Role of arginine and fluoride in the prevention of eroded enamel: an in vitro model

Role of arginine and fluoride in the prevention of eroded enamel: an in vitro model

Background The aim of this study was to investigate the effect of arginine and fluoride on the reduction of erosive wear. Methods Bovine enamel blocks were randomly allocated into four groups (n = 20) and exposed to: ESPR group (8% arginine, 1450 ppm sodium monofluorophosphate, calcium carbonate and...

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Published in:Australian dental journal Vol. 58; no. 4; pp. 478 - 482
Main Authors: Yamashita, JM, Torres, NM, Moura‐Grec, PG, Marsicano, JA, Sales‐Peres, A, Sales‐Peres, SHC
Format: Journal Article
Language:English
Published: Australia 01-12-2013
Subjects:
Animals
Arginine
Arginine - pharmacology
Calcium Carbonate - pharmacology
Cattle
Dental Enamel - drug effects
Dentistry
enamel wear
Fluorides - pharmacology
Hardness
Phosphates - pharmacology
Potassium Citrate - pharmacology
Random Allocation
Saliva, Artificial
Sodium Fluoride - pharmacology
Tooth Erosion - prevention & control
Tooth Remineralization - methods
toothpaste
Toothpastes - chemistry
Toothpastes - pharmacology
Arginine
enamel wear
toothpaste
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Summary:Background The aim of this study was to investigate the effect of arginine and fluoride on the reduction of erosive wear. Methods Bovine enamel blocks were randomly allocated into four groups (n = 20) and exposed to: ESPR group (8% arginine, 1450 ppm sodium monofluorophosphate, calcium carbonate and titanium dioxide); ESen group (1450 ppm sodium monofluorophosphate, 5% potassium citrate); positive control PC group (1500 ppm sodium monofluorophosphate) and negative control NC group (water). The samples were submitted to six alternating cycles of demineralization–remineralization (cola, 10 minutes; artificial saliva, 1 hour, respectively). Before and between cyclic demineralization and remineralization, blocks were treated with slurries of the respective toothpastes or water (1 minute). Erosive tissue loss was analysed by microhardness and profilometry. Data were analysed by ANOVA and Tukey tests for individual comparisons among the groups (p < 0.05). Results In microhardness, the ESPR (217.46 ± 55.45) group was significantly better than the other treatment groups (PC = 302.76 ± 96.10; ESen = 315.56 ± 74.56; p < 0.001). The ESPR group showed a similar loss to NC group (NC = 210.8 ± 49.98; p = 0.991). The mean erosion depth (+/– SE, μm) was detected between NC (14.37 ± 1.72) and dentifrices tested (ESPR (4.11 ± 1.34), ESen group (7.64 ± 1.61) and PC (8.20 ± 2.19) (p = 0.000). Conclusions From the results of the present study, the effectiveness of Sensitive Pro Relief in the prevention of erosive surface loss seems to be attributed to the possible effect of the arginine associated with fluoride.
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ISSN:0045-0421
1834-7819
DOI:10.1111/adj.12110