Search Results - "Yamashita, Arisa"

CLN6’s luminal tail-mediated functional interference between CLN6 mutants as a novel pathomechanism for the neuronal ceroid lipofuscinoses by SHIRO, Yuki, YAMASHITA, Arisa, WATANABE, Kana, YAMAZAKI, Tetsuo

“…CLN6 (Ceroid Lipofuscinosis, Neuronal, 6) is a 311-amino acid protein spanning the endoplasmic reticulum membrane. Mutations in CLN6 are linked to CLN6…”
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Functional evaluation and characterization of a newly developed silicone oil-free prefillable syringe system by Yoshino, Keisuke, Nakamura, Koji, Yamashita, Arisa, Abe, Yoshihiko, Iwasaki, Kazuhiro, Kanazawa, Yukie, Funatsu, Kaori, Yoshimoto, Tsuyoshi, Suzuki, Shigeru

“…The functionality of a newly developed silicone oil-free (SOF) syringe system, of which the plunger stopper is coated by a novel coating technology…”
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Involvement of reactive oxygen species in osteoblastic differentiation of MC3T3-E1 cells accompanied by mitochondrial morphological dynamics by ARAKAKI, Naokatu, YAMASHITA, Arisa, NIIMI, Shingo, YAMAZAKI, Tetsuo

“…Bone remodeling is regulated by local factors that regulate bone-forming osteoblasts and boneresorbing osteoclasts, in addition to hormonal activity. Recent…”
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Assessment of the effects of sterilization methods on protein drug stability by elucidating decomposition mechanism and material analysis by Nakamura, Koji, Kiminami, Hideaki, Yamashita, Arisa, Abe, Yoshihiko, Yoshino, Keisuke, Suzuki, Shigeru

“…[Display omitted] The effects of different sterilization methods on the stability of highly sensitive protein drugs were assessed by elucidating mechanism…”
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Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death by Yamashita, Arisa, Taniwaki, Tatsuya, Kaikoi, Yuka, Yamazaki, Tetsuo

“…•Knockdown of the ER protein mitsugumin23 (MG23) enhances UVC-induced cell death.•The small heat shock protein αB-crystallin was identified as a MG23…”
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Mitochondrial development of the in vitro hepatic organogenesis model with simultaneous cardiac mesoderm differentiation from murine induced pluripotent stem cells by Tamai, Miho, Yamashita, Arisa, Tagawa, Yoh-ichi

“…Induced pluripotent stem (iPS) cells, resembling embryonic stem (ES) cells in many phenomena, including differentiation potential, colony morphology, and the…”
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Identification of CLN6 as a molecular entity of endoplasmic reticulum-driven anti-aggregate activity by Yamashita, Arisa, Hiraki, Yuri, Yamazaki, Tetsuo

“…αB-crystallin (αBC) is a small heat shock protein. Mutations in the αBC gene are linked to α-crystallinopathy, a hereditary myopathy histologically…”
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p.Asn77Lys homozygous CLN6 mutation in two unrelated Japanese patients with Kufs disease, an adult onset neuronal ceroid lipofuscinosis by Onodera, Misaki, Tsujimoto, Saori, Doi, Syusuke, Yamashita, Arisa, Yamazaki, Tetsuo, Makifuchi, Takao, Inazu, Tetsuya

“…•Homozygous mutations were identified in two unrelated patients with Kufs disease.•Missense mutation was found in CLN6 exon 3 (c.231C > G,…”
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Prevention of aberrant protein aggregation by anchoring the molecular chaperone αB-crystallin to the endoplasmic reticulum by Yamamoto, Shinichiro, Yamashita, Arisa, Arakaki, Naokatu, Nemoto, Hisao, Yamazaki, Tetsuo

“…•ER-anchored αB-crystallin (αBC) prevents aggregation of the R120G αBC mutant.•ER-anchored αBC reduces the amount of the R120G mutant via…”
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Comparison of Scheimpflug and Anterior Segment Optical Coherence Tomography Imaging Parameters for Japanese Patients With Fuchs Endothelial Corneal Dystrophy With and Without TCF4 Repeat Expansions by Maeno, Sayo, Oie, Yoshinori, Koto, Ryota, Nishida, Nozomi, Yamashita, Arisa, Yoshioka, Michika, Kai, Chifune, Soma, Takeshi, Koh, Shizuka, Yoshihara, Masahito, Kawasaki, Ryo, Jhanji, Vishal, Nakamori, Masayuki, Tsujikawa, Motokazu, Nishida, Kohji

“…The aim of this study was to investigate the association between cytosine-thymine-guanine trinucleotide repeat (TNR) expansion in TCF4 and the clinical…”
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Implications of graded reductions in CLN6’s anti-aggregate activity for the development of the neuronal ceroid lipofuscinoses by Yamashita, Arisa, Shiro, Yuki, Hiraki, Yuri, Yujiri, Takatoshi, Yamazaki, Tetsuo

“…CLN6, spanning the endoplasmic reticulum membrane, is a protein of unknown function. Mutations in the CLN6 gene are linked to an autosomal recessively…”
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Genetic variants of SMAD2/3/4/7 are associated with susceptibility to ulcerative colitis in a Japanese genetic background by Yamashita, Arisa, Inamine, Tatsuo, Suzuki, Shota, Fukuda, Sayaka, Unoike, Miki, Kawafuchi, Yuka, Machida, Haruhisa, Isomoto, Hajime, Nakao, Kazuhiko, Tsukamoto, Kazuhiro

“…•Polymorphisms of SMAD2/3/4/7 were associated with susceptibility to UC in Japanese.•The polymorphisms were not associated with CD susceptibility.•The…”
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A strategy for the prevention of protein oxidation by drug product in polymer-based syringes by Nakamura, Koji, Abe, Yoshihiko, Kiminami, Hideaki, Yamashita, Arisa, Iwasaki, Kazuhiro, Suzuki, Shigeru, Yoshino, Keisuke, Dierick, William, Constable, Kevin

“…Recently, new and advanced ideas have been presented on the value of polymer-based syringes for improved safety, better strength, reduced aggregation, and the…”
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