Search Results - "Yamasaki, Tomonori"

Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor by Honma, Daisuke, Kanno, Osamu, Watanabe, Jun, Kinoshita, Junzo, Hirasawa, Makoto, Nosaka, Emi, Shiroishi, Machiko, Takizawa, Takeshi, Yasumatsu, Isao, Horiuchi, Takao, Nakao, Akira, Suzuki, Keisuke, Yamasaki, Tomonori, Nakajima, Katsuyoshi, Hayakawa, Miho, Yamazaki, Takanori, Yadav, Ajay Singh, Adachi, Nobuaki

“…Polycomb repressive complex 2 (PRC2) methylates histone H3 lysine 27 and represses gene expression to regulate cell proliferation and differentiation. Enhancer…”
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Modeling and Reproducibility of Suzaku HXD PIN/GSO Background by Fukazawa, Yasushi, Mizuno, Tsunefumi, Watanabe, Shin, Kokubun, Motohide, Takahashi, Hiromitsu, Kawano, Naomi, Nishino, Sho, Sasada, Mahito, Shirai, Hirohisa, Takahashi, Takuya, Umeki, Yudai, Yamasaki, Tomonori, Yasuda, Tomonori, Bamba, Aya, Ohno, Masanori, Takahashi, Tadayuki, Ushio, Masayoshi, Enoto, Teruaki, Kitaguchi, Takao, Makishima, Kazuhiro, Nakazawa, Kazuo, Uehara, Yuichi, Yamada, Shin’ya, Yuasa, Takayuki, Isobe, Naoki, Kawaharada, Madoka, Tanaka, Takaaki, Tashiro, Makoto S., Terada, Yukikatsu, Yamaoka, Kazutaka

“…Suzaku Hard X-ray Detector (HXD) achieved the lowest background level than any other previously or currently operational missions sensitive in the energy range…”
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A Novel Inhibitor of I-KappaB Kinase Beta Ameliorates Experimental Arthritis through Downregulation of Proinflammatory Cytokines in Arthritic Joints by Tanaka, Shinji, Toki, Tadashi, Yokoyama, Mika, Shimizu, Hiroki, Yamasaki, Tomonori, Yoneda, Yoshiyuki, Muro, Fumihito, Yasukochi, Takanori, Iimura, Shin, Morishita, Kaoru

“…Inhibitor of kappaB (IκB) kinase beta (IKKβ) plays a critical role in nuclear factor-kappaB (NF-κB) activation and production of proinflammatory cytokines in…”
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Five Cases of Anesthetic Management for Emergent Hysterectomy with Postpartum Hemorrhage after Vaginal Delivery by Yamasaki, Tomonori, Komasawa, Nobuyasu, Omoto, Haruka, Minami, Toshiaki

“…Anesthetic management for emergent hysterectomy with postpartum hemorrhage after vaginal delivery is often difficult due to disseminated intravascular coagu-…”
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Fe-K Line Probing of Material Around the Active Galactic Nucleus Central Engine with Suzaku by Fukazawa, Yasushi, Hiragi, Kazuyoshi, Mizuno, Motohiro, Nishino, Sho, Hayashi, Katsuhiro, Yamasaki, Tomonori, Shirai, Hirohisa, Takahashi, Hiromitsu, Ohno, Masanori

“…We systematically analyzed the high-quality Suzaku data of 88 Seyfert galaxies, about 31% of which are Compton-thick active galactic nuclei (AGNs). We obtained…”
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Development and Characterization of the Novel Orally Bioavailable EZH1/2 Dual Inhibitor DS-3201 by Honma, Daisuke, Adachi, Nobuaki, Kanno, Osamu, Watanabe, Jun, Hirasawa, Makoto, Nosaka, Emi, Shiroishi, Machiko, Takizawa, Takeshi, Yasumatsu, Isao, Horiuchi, Takao, Nakao, Akira, Suzuki, Keisuke, Yamasaki, Tomonori, Nakajima, Katsuyoshi, Hayakawa, Miho, Yamazaki, Takanori, Araki, Kazushi, Fujiwara, Kosaku

“…Polycomb repressive complex 2 (PRC2) methylates histone H3 lysine 27 (H3K27) and represses gene expression to regulate cell proliferation and differentiation…”
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Discovery of imidazo[1,2- b]pyridazines as IKKβ inhibitors. Part 3: Exploration of effective compounds in arthritis models by Shimizu, Hiroki, Yamasaki, Tomonori, Yoneda, Yoshiyuki, Muro, Fumihito, Hamada, Tomoaki, Yasukochi, Takanori, Tanaka, Shinji, Toki, Tadashi, Yokoyama, Mika, Morishita, Kaoru, Iimura, Shin

“…We have discovered imidazo[1,2- b]pyridazine derivatives that show suppressive activity of inflammation in arthritis models. We optimized the substructures of…”
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Discovery of imidazo[1,2- b]pyridazine derivatives as IKKβ inhibitors. Part 1: Hit-to-lead study and structure–activity relationship by Shimizu, Hiroki, Tanaka, Shinji, Toki, Tadashi, Yasumatsu, Isao, Akimoto, Toshihiko, Morishita, Kaoru, Yamasaki, Tomonori, Yasukochi, Takanori, Iimura, Shin

“…We developed the HTS-hit imidazo[1,2- b]pyridazine derivatives and acquired some potent compounds such as 8e. These compounds showed potent IKKβ inhibitory…”
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Discovery of imidazo[1,2- b]pyridazines as IKKβ inhibitors. Part 2: Improvement of potency in vitro and in vivo by Shimizu, Hiroki, Yasumatsu, Isao, Hamada, Tomoaki, Yoneda, Yoshiyuki, Yamasaki, Tomonori, Tanaka, Shinji, Toki, Tadashi, Yokoyama, Mika, Morishita, Kaoru, Iimura, Shin

“…We have increased the potency of imidazo[1,2- b]pyridazine derivatives as IKKβ inhibitors with two strategies. One is to enhance the activity in cell-based…”
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Fe-K LINE PROBING OF MATERIAL AROUND THE ACTIVE GALACTIC NUCLEUS CENTRAL ENGINE WITH SUZAKU by FUKAZAWA, Yasushi, HIRAGI, Kazuyoshi, MIZUNO, Motohiro, NISHINO, Sho, HAYASHI, Katsuhiro, YAMASAKI, Tomonori, SHIRAI, Hirohisa, TAKAHASHI, Hiromitsu, OHNO, Masanori

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Revealing the High Energy Emission from the Obscured Seyfert Galaxy MCG−5–23–16 with Suzaku by Reeves, James N., Awaki, Hisamitsu, Dewangan, Gulab C., Fabian, Andy C., Fukazawa, Yasushi, Gallo, Luigi, Griffiths, Richard, Inoue, Hajime, Kunieda, Hideyo, Markowitz, Alex, Miniutti, Giovanni, Mizuno, Tsunefumi, Mushotzky, Richard, Okajima, Takashi, Ptak, Andy, Takahashi, Tadayuki, Terashima, Yuichi, Ushio, Masayoshi, Watanabe, Shin, Yamasaki, Tomonori, Yamauchi, Makoto, Yaqoob, Tahir

“…We report on a 100 ks Suzaku observation of the bright, nearby ( $z=0.008486$ ) Seyfert 1.9 galaxy MCG $-$ 5–23–16. The broad-band (0.4–100 keV) X-ray spectrum…”
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Reduction of Peptide Character of HIV Protease Inhibitors That Exhibit Nanomolar Potency against Multidrug Resistant HIV-1 Strains by Tamamura, Hirokazu, Koh, Yasuhiro, Ueda, Satoshi, Sasaki, Yoshikazu, Yamasaki, Tomonori, Aoki, Manabu, Maeda, Kenji, Watai, Yoriko, Arikuni, Hisashi, Otaka, Akira, Mitsuya, Hiroaki, Fujii, Nobutaka

“…Novel HIV protease inhibitors containing a hydroxyethylamine dipeptide isostere as a transition state-mimic king structure were synthesized by combining…”
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Discovery of imidazo[1,2-b]pyridazine derivatives as IKKbeta inhibitors. Part 1: Hit-to-lead study and structure-activity relationship by Shimizu, Hiroki, Tanaka, Shinji, Toki, Tadashi, Yasumatsu, Isao, Akimoto, Toshihiko, Morishita, Kaoru, Yamasaki, Tomonori, Yasukochi, Takanori, Iimura, Shin

“…Imidazo[1,2-b]pyridazine derivatives from high-throughput screening were developed as IKKbeta inhibitors. By the optimization of the 3- and 6-position of…”
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Fe-K line probing of material around the AGN central engine with Suzaku by Fukazawa, Yasushi, Hiragi, Kazuyoshi, Mizuno, Motohiro, Nishino, Sho, Hayashi, Katsuhiro, Yamasaki, Tomonori, Shirai, Hirohisa, Takahashi, Hiromitsu, Ohno, Masanori

“…We systematically analyzed the high-quality Suzaku data of 88 Seyfert galaxies. We obtained a clear relation between the absorption column density and the…”
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Modeling and Reproducibility of Suzaku HXD PIN/GSO Background by Fukazawa, Yasushi, Mizuno, Tsunefumi, Watanabe, Shin, Kokubun, Motohide, Takahashi, Hiromitsu, Kawano, Naomi, Nishino, Sho, Sasada, Mahito, Shirai, Hirohisa, Takahashi, Takuya, Yamasaki, Tomonori, Yasuda, Tomonori, Bamba, Aya, Ohno, Masanori, Takahashi, Tadayuki, Ushio, Masayoshi, Enoto, Teruaki, Kitaguchi, Takao, Makishima, Kazuo, Nakazawa, Kazuhiro, Uehara, Yuichi, Yamada, Shin'ya, Yuasa, Takayuki, Isobe, Naoki, Kawaharada, Madoka, Tanaka, Takaaki, Tashiro, Makoto, Terada, Yukikatsu, Yamaoka, Kazutaka

“…Suzaku Hard X-ray Detector (HXD) achieved the lowest background level than any other previously or currently operational missions sensitive in the energy range…”
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Revealing the High Energy Emission from the Obscured Seyfert Galaxy MCG -5-23-16 with Suzaku by Reeves, James N, Awaki, Hisamitsu, Dewangan, Gulab C, Fabian, Andy C, Fukazawa, Yasushi, Gallo, Luigi, Griffiths, Richard, Inoue, Hajime, Kunieda, Hideyo, Markowitz, Alex, MiniuttI, Giovanni, Mizuno, Tsunefumi, Mushotzky, Richard, Okajima, Takashi, Ptak, Andy, Takahashi, Tadayuki, Terashima, Yuichi, Ushio, Masayoshi, Watanabe, Shin, Yamasaki, Tomonori, Yamauchi, Makoto, Yaqoob, Tahir

“…We report on a 100 ks Suzaku observation of the bright, nearby (z=0.008486) Seyfert 1.9 galaxy MCG -5-23-16. The broad-band (0.4-100 keV) X-ray spectrum allows…”
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