Search Results - "Yamasaki, Kenshi"

Psoriasis and Antimicrobial Peptides by Takahashi, Toshiya, Yamasaki, Kenshi

“…Psoriasis is a systemic inflammatory disease caused by crosstalk between various cells such as T cells, neutrophils, dendritic cells, and keratinocytes…”
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Melanogenesis Connection with Innate Immunity and Toll-Like Receptors by Koike, Saaya, Yamasaki, Kenshi

“…The epidermis is located in the outermost layer of the living body and is the place where external stimuli such as ultraviolet rays and microorganisms first…”
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Perspectives on rosacea patient characteristics and quality of life using baseline data from a phase 3 clinical study conducted in Japan by Yamasaki, Kenshi, Miyachi, Yoshiki

“…There is a lack of contemporary data on rosacea originating in Japan. Using baseline data from a randomized, phase 3 study of 130 Japanese patients with…”
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The molecular pathology of rosacea by Yamasaki, Kenshi, Gallo, Richard L

“…Abstract Rosacea is a common and chronic inflammatory skin disease that affects over 10 million Americans. Although the phenotypes of rosacea are clinically…”
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Rosacea as a disease of cathelicidins and skin innate immunity by Yamasaki, Kenshi, Gallo, Richard L

“…Rosacea is a common and chronic inflammatory skin disease most frequently seen in groups of genetically related individuals. Although the symptoms of rosacea…”
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Facial UV photo imaging for skin pigmentation assessment using conditional generative adversarial networks by Kojima, Kaname, Shido, Kosuke, Tamiya, Gen, Yamasaki, Kenshi, Kinoshita, Kengo, Aiba, Setsuya

“…Skin pigmentation is associated with skin damages and skin cancers, and ultraviolet (UV) photography is used as a minimally invasive mean for the assessment of…”
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Metronidazole gel (0.75%) in Japanese patients with rosacea: A randomized, vehicle‐controlled, phase 3 study by Miyachi, Yoshiki, Yamasaki, Kenshi, Fujita, Tomomitsu, Fujii, Chie

“…Topical metronidazole is not currently approved in Japan as a treatment for the indication of rosacea, although 0.75% metronidazole gel was authorized in 2014…”
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The Antimicrobial Peptide Cathelicidin Exerts Immunomodulatory Effects via Scavenger Receptors by Amagai, Ryo, Takahashi, Toshiya, Terui, Hitoshi, Fujimura, Taku, Yamasaki, Kenshi, Aiba, Setsuya, Asano, Yoshihide

“…An active form of cathelicidin antimicrobial peptide, LL-37, has immunomodulatory and stimulatory effects, though the specific pathways are not clear. The…”
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TLR2 Expression Is Increased in Rosacea and Stimulates Enhanced Serine Protease Production by Keratinocytes by Yamasaki, Kenshi, Kanada, Kimberly, Macleod, Daniel T., Borkowski, Andrew W., Morizane, Shin, Nakatsuji, Teruaki, Cogen, Anna L., Gallo, Richard L.

“…A diverse environment challenges skin to maintain temperature, hydration, and electrolyte balance while also maintaining normal immunological function. Rosacea…”
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Ustekinumab treatment for hidradenitis suppurativa by Takeda, Kana, Kikuchi, Katsuko, Kanazawa, Yoshitake, Yamasaki, Kenshi, Aiba, Setsuya

“…Hidradenitis suppurativa (HS) is a follicular occlusive inflammatory skin disease that occurs in the axilla, groin, buttocks and vulval region. Control of the…”
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Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea by Coda, Alvin, Murakami, Masamoto, Descargues, Pascal, Dorschner, Robert A, Hovnanian, Alain, Gallo, Richard L, Ohtake, Takaaki, Di Nardo, Anna, Bonnart, Chrystelle, Yamasaki, Kenshi, Bardan, Antonella, Morhenn, Vera B

“…Acne rosacea is an inflammatory skin disease that affects 3% of the US population over 30 years of age and is characterized by erythema, papulopustules and…”
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Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts by Kumtornrut, Chanat, Yamauchi, Takeshi, Koike, Saaya, Aiba, Setsuya, Yamasaki, Kenshi

“…•Androgens enhance AREG, EREG, FGF10, and IGFBP5 production from fibroblasts through androgen receptors.•AREG, EREG, FGF10, and IGFBP5 are more abundant in…”
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Adalimumab in Japanese patients with active ulcers of pyoderma gangrenosum: Twenty‐six‐week phase 3 open‐label study by Yamasaki, Kenshi, Yamanaka, Keiichi, Zhao, Yiwei, Iwano, Shunsuke, Takei, Keiko, Suzuki, Koji, Yamamoto, Toshiyuki

“…This phase 3 multicenter study, including 26‐week treatment and extension periods, evaluated the efficacy and safety of adalimumab in Japanese patients with…”
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Adalimumab in Japanese patients with active ulcers of pyoderma gangrenosum: Final analysis of a 52‐week phase 3 open‐label study by Yamasaki, Kenshi, Yamanaka, Keiichi, Zhao, Yiwei, Iwano, Shunsuke, Takei, Keiko, Suzuki, Koji, Yamamoto, Toshiyuki

“…In this 52‐week, phase 3 open‐label study, efficacy and safety of adalimumab were evaluated in Japanese patients with active ulcers due to pyoderma gangrenosum…”
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Japanese Dermatological Association Guidelines: Guidelines for the treatment of acne vulgaris 2017 by Hayashi, Nobukazu, Akamatsu, Hirohiko, Iwatsuki, Keiji, Shimada‐Omori, Ryoko, Kaminaka, Chikako, Kurokawa, Ichiro, Kono, Takeshi, Kobayashi, Miwa, Tanioka, Miki, Furukawa, Fukumi, Furumura, Minao, Yamasaki, Osamu, Yamasaki, Kenshi, Yamamoto, Yuki, Miyachi, Yoshiki, Kawashima, Makoto

“…The Guidelines for the Treatment of Acne Vulgaris of the Japanese Dermatological Association was first published in Japanese in 2008 and revised in 2016 and…”
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Administration of oral vitamin D induces cathelicidin production in atopic individuals by Hata, Tissa R., MD, Kotol, Paul, BS, Jackson, Michelle, MD, Nguyen, Meggie, BS, Paik, Aimee, MD, Udall, Don, MD, Kanada, Kimi, BS, Yamasaki, Kenshi, MD, PhD, Alexandrescu, Doru, MD, Gallo, Richard L., MD, PhD

“…To the Editor: Atopic dermatitis (AD) is a chronic skin condition that affects 10% to 20% of children and 1% to 3% of adults.1 Individuals with atopic…”
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Cathelicidin Antimicrobial Peptide LL-37 in Psoriasis Enables Keratinocyte Reactivity against TLR9 Ligands by Morizane, Shin, Yamasaki, Kenshi, Mühleisen, Beda, Kotol, Paul F., Murakami, Masamoto, Aoyama, Yumi, Iwatsuki, Keiji, Hata, Tissa, Gallo, Richard L.

“…Here we show that keratinocytes in psoriatic lesional skin express increased Toll-like receptor (TLR) 9 that similarly localizes with elevated expression of…”
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Selective Antimicrobial Action Is Provided by Phenol-Soluble Modulins Derived from Staphylococcus epidermidis, a Normal Resident of the Skin by Cogen, Anna L., Yamasaki, Kenshi, Sanchez, Katheryn M., Dorschner, Robert A., Lai, Yuping, MacLeod, Daniel T., Torpey, Justin W., Otto, Michael, Nizet, Victor, Kim, Judy E., Gallo, Richard L.

“…Antimicrobial peptides serve as a first line of innate immune defense against invading organisms such as bacteria and viruses. In this study, we hypothesized…”
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Toll-like receptor 2 utilizes RAB11A for melanosome transfer from melanocytes to keratinocytes by Koike, Saaya, Yamasaki, Kenshi, Yamauchi, Takeshi, Shimada-Omori, Ryoko, Tsuchiyama, Kenichiro, Aiba, Setsuya

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Red light-promoted skin barrier recovery: Spatiotemporal evaluation by transepidermal potential by Abe, Yuina, Konno, Hajime, Yoshida, Shotaro, Yamauchi, Takeshi, Yamasaki, Kenshi, Denda, Mitsuhiro, Nishizawa, Matsuhiko

“…The light-promoted recovery of epidermal barrier of skin was evaluated by the associated recovery of transepidermal potential (TEP), the potential difference…”
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