Difference in the effect of adiposity on bone density between pre- and postmenopausal women

Difference in the effect of adiposity on bone density between pre- and postmenopausal women

Objectives: Elevated bone mineral density (BMD) in obese women is partially attributable to the higher circulating estrogen levels derived from extraglandular aromatization in adipose tissue. However, it remains unclear whether there is an effect of overall adiposity on BMD in both pre- and postmeno...

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Bibliographic Details
Published in:Maturitas Vol. 34; no. 3; pp. 261 - 266
Main Authors: Douchi, Tsutomu, Yamamoto, Shinako, Oki, Toshimichi, Maruta, Kuninori, Kuwahata, Riki, Yamasaki, Hedeki, Nagata, Yukihiro
Format: Journal Article
Language:English
Published: Shannon Elsevier Ireland Ltd 31-03-2000
Elsevier Science
Subjects:
Absorptiometry, Photon
Adipose Tissue - anatomy & histology
Adiposity
Adult
Aged
Anthropometry
Biological and medical sciences
Body Composition - physiology
Body Mass Index
Bone Density
Bone mineral density
Cross-Sectional Studies
Female
Gynecology. Andrology. Obstetrics
Humans
Lumbar Vertebrae - physiology
Medical sciences
Middle Aged
Obesity - physiopathology
Postmenopause
Premenopause
Puberal and climacteric disorders (male and female)
Women
Women
Adiposity
Bone mineral density
Human
Obesity
Premenopause
Menopause
Nutrition disorder
Female
Bone
Density
Nutritional status
Comparative study
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Summary:Objectives: Elevated bone mineral density (BMD) in obese women is partially attributable to the higher circulating estrogen levels derived from extraglandular aromatization in adipose tissue. However, it remains unclear whether there is an effect of overall adiposity on BMD in both pre- and postmenopausal women. The difference in the effect of overall adiposity on BMD between pre- and postmenopausal women was investigated. Materials and methods: Subjects were 296 premenopausal women with regular menstruation and 233 postmenopausal women. Age, age at menarche, years since menopause (YSM, in postmenopausal women), weight, height, and body mass index were recorded. Total fat mass amount, lean mass amount, and percentage of body fat were measured by whole body scanning with dual-energy X-ray absorptiometry (DEXA). Lumbar spine BMD (L2–L4) was measured by DEXA. In each group, significant determinants of BMD were investigated using univariate and stepwise multiple regression analysis. Results: In postmenopausal women, YSM, lean mass amount, total fat mass amount, and height were significant determinants of BMD ( R 2=0.273, P<0.001). In premenopausal women, only two variables including lean mass amount and age at menarche were significant determinants of lumbar spine BMD ( R 2=0.110, P<0.001), but total fat mass amount and percentage of body fat were not significant determinants of BMD. Conclusion: The effect of overall adiposity on BMD is more prominent in postmenopausal women than in premenopausal women.
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ISSN:0378-5122
1873-4111
DOI:10.1016/S0378-5122(99)00114-0