Search Results - "Yamane, Naoe"

Fully validated LCMS bioanalysis of Bevacizumab in human plasma using nano-surface and molecular-orientation limited (nSMOL) proteolysis by Iwamoto, Noriko, Umino, Yukari, Aoki, Chikage, Yamane, Naoe, Hamada, Akinobu, Shimada, Takashi

“…The chemistry of nano-surface and molecular-orientation limited (nSMOL) proteolysis is the Fab-selective limited proteolysis by making use the difference of…”
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High‐performance liquid chromatography–tandem mass spectrometry for simultaneous determination of raltegravir, dolutegravir and elvitegravir concentrations in human plasma and cerebrospinal fluid samples by Tsuchiya, Kiyoto, Ohuchi, Mayu, Yamane, Naoe, Aikawa, Hiroaki, Gatanaga, Hiroyuki, Oka, Shinichi, Hamada, Akinobu

“…A simple sample treatment procedure and sensitive liquid chromatography–tandem mass spectrometry method were developed for the simultaneous quantification of…”
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Microdosing clinical study to clarify pharmacokinetic and pharmacogenetic characteristics of atorvastatin in Japanese hypercholesterolemic patients by Lee, Nora, Maeda, Kazuya, Fukizawa, Shinya, Ieiri, Ichiro, Tomaru, Atsuko, Akao, Hironobu, Takeda, Kenji, Iwadare, Mizuho, Niwa, Osamu, Masauji, Tougen, Yamane, Naoe, Kajinami, Kouji, Kusuhara, Hiroyuki, Sugiyama, Yuichi

“…The present study investigated whether the clinical pharmacokinetics of atorvastatin can be predicted from the results of microdosing study in Japanese…”
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Microdose clinical trial: Quantitative determination of fexofenadine in human plasma using liquid chromatography/electrospray ionization tandem mass spectrometry by Yamane, Naoe, Tozuka, Zenzaburou, Sugiyama, Yuichi, Tanimoto, Toshiko, Yamazaki, Akira, Kumagai, Yuji

“…A sample treatment procedure and high-sensitive liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method for quantitative…”
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Cost-effectiveness Analysis of Microdose Clinical Trials in Drug Development by Yamane, Naoe, Igarashi, Ataru, Kusama, Makiko, Maeda, Kazuya, Ikeda, Toshihiko, Sugiyama, Yuichi

“…Microdose (MD) clinical trials have been introduced to obtain human pharmacokinetic data early in drug development. Here we assessed the cost-effectiveness of…”
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Mechanisms of Pharmacokinetic Enhancement Between Ritonavir and Saquinavir; Micro/Small Dosing Tests Using Midazolam (CYP3A4), Fexofenadine (p-Glycoprotein), and Pravastatin (OATP1B1) as Probe Drugs by Ieiri, Ichiro, Tsunemitsu, Shyohei, Maeda, Kazuya, Ando, Yukie, Izumi, Noritomo, Kimura, Miyuki, Yamane, Naoe, Okuzono, Tsuyoshi, Morishita, Mariko, Kotani, Naoki, Kanda, Eri, Deguchi, Mariko, Matsuguma, Kyoko, Matsuki, Shunji, Hirota, Takeshi, Irie, Shin, Kusuhara, Hiroyuki, Sugiyama, Yuichi

“…We investigated the mechanisms of ritonavir‐mediated enhancement effect on the pharmacokinetics of saquinavir using in vivo probes for CYP3A4 (midazolam),…”
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Clinical Relevance of Liquid Chromatography Tandem Mass Spectrometry as an Analytical Method in Microdose Clinical Studies by Yamane, Naoe, Tozuka, Zenzaburo, Kusama, Makiko, Maeda, Kazuya, Ikeda, Toshihiko, Sugiyama, Yuichi

“…ABSTRACT Purpose To investigate the potency of LC-MS/MS by means of sensitivity and the applicability for cassette dosing in microdose clinical trials. Methods…”
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Microdose Clinical Trial: Quantitative Determination of Nicardipine and Prediction of Metabolites in Human Plasma by Yamane, Naoe, Takami, Tomonori, Tozuka, Zenzaburo, Sugiyama, Yuichi, Yamazaki, Akira, Kumagai, Yuji

“…A sample treatment procédure and high-sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for quantitative determination of nicardipine…”
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Determination of branched beta-cyclodextrin-prostaglandin complexes using electrospray ionization mass spectrometry by Yamane, N.(JCL Bioassay Corp., Nishiwaki, Hyogo (Japan)), Tozuka, Z, Okada, Y, Honda, C, Nishi, Y, Tanimoto, T

“…Mass spectral measurements by electrospray ionization mass spectrometry (ESI-MS) detected the ions of beta-cyclodextrin (betaCD) or branched betaCDs…”
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Preparation and characterization of 6I,6n-di-O-(L-fucopyranosyl)-beta-cyclodextrin (n=II-IV) and investigation of their functions by Nishi, Yuki, Yamane, Naoe, Tanimoto, Toshiko

“…Three positional isomers of 6(I),6(n)-di-O-(beta-L-fucopyranosyl)-cyclomaltoheptaose [6(I),6(n)-di-O-(beta-L-Fuc)-beta-cyclodextrin, -betaCD, n=II-IV] were…”
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Preparation and characterization of 6 I,6 n -di- O-( l-fucopyranosyl)-β-cyclodextrin ( n = II–IV) and investigation of their functions by Nishi, Yuki, Yamane, Naoe, Tanimoto, Toshiko

“…Three positional isomers of 6 I,6 n -di- O-(β- l-fucopyranosyl)-cyclomaltoheptaose [6 I,6 n -di- O-(β- l-Fuc)-β-cyclodextrin, -βCD, n = II–IV] were chemically…”
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Determination of Branched [beta]-Cyclodextrin-Prostaglandin Complexes Using Electrospray Ionization Mass Spectrometry by YAMANE, Naoe, TOZUKA, Zenzaburo, OKADA, Yasuyo, HONDA, Chie, NISHI, Yuki, TANIMOTO, Toshiko

“…Mass spectral measurements by electrospray ionization mass spectrometry (ESI-MS) detected the ions of β-cyclodextrin (βCD) or branched βCDs (glucosyl-,…”
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