Search Results - "Yamamoto, Y L"

A new method to measure brain serotonin synthesis in vivo. I. Theory and basic data for a biological model by Diksic, M, Nagahiro, S, Sourkes, T L, Yamamoto, Y L

“…We describe here an autoradiographic method to measure the in vivo rate of serotonin synthesis in rat brain. The method is based on the use of the L-tryptophan…”
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Serotonin synthesis rate measured in living dog brain by positron emission tomography by Diksic, M, Nagahiro, S, Chaly, T, Sourkes, T L, Yamamoto, Y L, Feindel, W

“…In vivo measurements by positron emission tomography of the brain serotonin synthesis rates in the normal dog, in the dog with increased plasma tryptophan…”
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Rapid steady-state analysis of blood-brain transfer of L-Trp in rat, with special reference to the plasma protein binding by Takada, A, Grdisa, M, Diksic, M, Gjedde, A, Yamamoto, Y L

“…We estimated constants for the binding of tryptophan (Trp) to plasma proteins, and for the transfer of Trp from plasma to brain in rat. The measurements were…”
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The effect of spontaneous reperfusion on metabolic function in early human cerebral infarcts by Hakim, A M, Pokrupa, R P, Villanueva, J, Diksic, M, Evans, A C, Thompson, C J, Meyer, E, Yamamoto, Y L, Feindel, W H

“…Twelve patients were studied within 48 hours of stroke using positron emission tomography to determine cerebral blood flow (CBF), cerebral metabolic rate for…”
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A new method to measure brain serotonin synthesis in vivo. II. A practical autoradiographic method tested in normal and lithium-treated rats by Nagahiro, S, Takada, A, Diksic, M, Sourkes, T L, Missala, K, Yamamoto, Y L

“…We describe here a practical autoradiographic method to estimate the rate of serotonin synthesis in brain. A two-time point method (60 and 150 min after…”
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Effects of retrograde perfusion of the brain with combined drug therapy after focal ischemia in rat brain by SHIMAUCHI, M, YAMAMOTO, Y. L, KONTOS, H. A

“…The ischemic edema associated with blood-brain barrier permeability changes and the excess production of free radicals are serious complications in prolonged…”
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Regional cerebral blood flow changes in cortex and basal ganglia during voluntary movements in normal human volunteers by Roland, P E, Meyer, E, Shibasaki, T, Yamamoto, Y L, Thompson, C J

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Metabolic and Hemodynamic Evaluation of Gliomas Using Positron Emission Tomography by Tyler, J.L, Diksic, M, Villemure, J-G, Evans, A.C, Meyer, E, Yamamoto, Y.L, Feindel, W

“…Positron emission tomography (PET) was used on 16 patients with untreated cerebral gliomas to measure cerebral glucose and oxygen metabolism, oxygen…”
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Efficacy of retrograde perfusion of the cerebral vein with verapamil after focal ischemia in rat brain by HOSAKA, T, YAMAMOTO, Y. L, DIKSIC, M

“…For treatment of acute stroke, drug therapy administered systemically has been unreliable due to inadequate delivery of drug into ischemic tissue. We have…”
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Minimisation of parameter estimation errors in dynamic PET: choice of scanning schedules by Jovkar, S, Evans, A C, Diksic, M, Nakai, H, Yamamoto, Y L

“…We addressed the general problem of finding an optimal scan schedule in positron emission tomography (PET) dynamic studies which minimises the errors in…”
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The transfer coefficients for L-valine and the rate of incorporation of L-[1-14C] valine into proteins in normal adult rat brain by Kirikae, M, Diksic, M, Yamamoto, Y L

“…An autoradiographic method for the measurement of the rate of valine incorporation into brain proteins is described. The transfer coefficients for valine into…”
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Borderzone ischemia by Leblanc, R, Yamamoto, Y L, Tyler, J L, Diksic, M, Hakim, A

“…Positron emission tomography was used to measure cerebral perfusion and metabolism in 7 patients with severe carotid stenosis. None of the patients had…”
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Correlation of local cerebral blood flow, glucose utilization and tissue pH following a middle cerebral artery occlusion in the rat by SAKO, K, KOBATAKE, K, YAMAMOTO, Y. L, DIKSIC, M

“…The use of three sets of the double-tracer autoradiographic technique to measure topographical changes of local cerebral blood flow (LCBF), glucose utilization…”
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Alterations of local cerebral blood flow, phorbol 12,13-dibutyrate binding activity, and histological damage during acute focal ischaemia in rat brain : A pathophysiology of acute focal ischaemia: Part 1 by INOUE, N, YAMAMOTO, Y. L, NAGAO, T, GOTO, S, NAGAHIRO, S, USHIO, Y, BAETHMANN, A

“…The alterations of the local cerebral blood flow (LCBF), 3H-phorbol 12,13-dibutyrate (PDBu) binding activity were measured, and histological findings were also…”
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Permeability change and brain tissue damage after intracarotid administration of cisplatin studied by double-tracer autoradiography in rats by SUGIMOTO, S, YAMAMOTO, Y. L, NAGAHIRO, S, DIKSIC, M

“…The present study was designed to find the reliable parameter(s) for the detection of early neurotoxicity following intracarotid (IC) administration of…”
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Triple-tracer autoradiography demonstrates effects of hyperglycemia on cerebral blood flow, pH, and glucose utilization in cerebral ischemia of rats by NAKAI, H, YAMAMOTO, Y. L, DIKSIC, M, WORSLEY, K. J, TAKARA, E

“…Triple-tracer autoradiography was used to measure topographic changes in local cerebral blood flow, cerebral tissue pH, and local cerebral glucose utilization…”
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Stability of Regional Cerebral Glucose Metabolism in the Normal Brain Measured by Positron Emission Tomography by Tyler, J.L, Strother, S.C, Zatorre, R.J, Alivisatos, B, Worsley, K.J, Diksic, M, Yamamoto, Y.L

“…Cerebral glucose utilization (LCMRGI) was measured using the [18F]fluorodeoxyglucose method with PET in two groups of ten healthy young volunteers, each…”
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Quantification of glucose utilization in an experimental brain tumor model by the deoxyglucose method by Kato, A, Diksic, M, Yamamoto, Y L, Feindel, W

“…Reevaluation of lumped and rate constants is necessary when Sokoloff's 2-deoxyglucose (DG) method is used to measure glucose utilization in pathological…”
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In vivo measurement of [18F]fluorodeoxyglucose rate constants in rat brain by external coincidence counting by Redies, C, Matsuda, H, Diksic, M, Meyer, E, Yamamoto, Y L

“…The operational equation for the double-label deoxyglucose method described in the following paper requires the knowledge of the rate constants for transfer of…”
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Double-label autoradiographic deoxyglucose method for sequential measurement of regional cerebral glucose utilization by Redies, C, Diksic, M, Evans, A C, Gjedde, A, Yamamoto, Y L

“…A new double-label autoradiographic glucose analog method for the sequential measurement of altered regional cerebral metabolic rates for glucose in the same…”
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