Search Results - "Yamamoto, Ken‐ichi"

c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD+ cleavage activity to inhibit mitochondrial respiration by Murata, Hitoshi, Khine, Cho Cho, Nishikawa, Akane, Yamamoto, Ken-ichi, Kinoshita, Rie, Sakaguchi, Masakiyo

“…Mitochondrial dysfunction is a key pathological feature of many different types of neurodegenerative disease. Sterile alpha and Toll/interleukin receptor…”
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Psychiatric symptoms of noradrenergic dysfunction: A pathophysiological view by Yamamoto, Ken‐ichi, Shinba, Toshikazu, Yoshii, Mitsunobu

“…What psychiatric symptoms are caused by central noradrenergic dysfunction? The hypothesis considered in this review is that noradrenergic dysfunction causes…”
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The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1 by Delacroix, Sinny, Wagner, Jill M, Kobayashi, Masahiko, Yamamoto, Ken-ichi, Karnitz, Larry M

“…DNA replication stress triggers the activation of Checkpoint Kinase 1 (Chk1) in a pathway that requires the independent chromatin loading of the ATRIP-ATR…”
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Newly developed anti‐S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis by Kinoshita, Rie, Sato, Hiroki, Yamauchi, Akira, Takahashi, Yuta, Inoue, Yusuke, Sumardika, I Wayan, Chen, Youyi, Tomonobu, Nahoko, Araki, Kota, Shien, Kazuhiko, Tomida, Shuta, Torigoe, Hidejiro, Namba, Kei, Kurihara, Eisuke, Ogoshi, Yusuke, Murata, Hitoshi, Yamamoto, Ken‐ichi, Futami, Junichiro, Putranto, Endy Widya, Ruma, I Made Winarsa, Yamamoto, Hiromasa, Soh, Junichi, Hibino, Toshihiko, Nishibori, Masahiro, Kondo, Eisaku, Toyooka, Shinichi, Sakaguchi, Masakiyo

“…The metastatic dissemination of cancer cells to remote areas of the body is the most problematic aspect in cancer patients. Among cancers, melanomas are…”
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TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding by Sakaguchi, Masakiyo, Murata, Hitoshi, Yamamoto, Ken-ichi, Ono, Tomoyuki, Sakaguchi, Yoshihiko, Motoyama, Akira, Hibino, Toshihiko, Kataoka, Ken, Huh, Nam-ho

“…The receptor for advanced glycation end products (RAGE) is thought to be involved in the pathogenesis of a broad range of inflammatory, degenerative and…”
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Neuroplastin‐β mediates S100A8/A9‐induced lung cancer disseminative progression by Sumardika, I Wayan, Chen, Youyi, Tomonobu, Nahoko, Kinoshita, Rie, Ruma, I Made Winarsa, Sato, Hiroki, Kondo, Eisaku, Inoue, Yusuke, Yamauchi, Akira, Murata, Hitoshi, Yamamoto, Ken‐ichi, Tomida, Shuta, Shien, Kazuhiko, Yamamoto, Hiromasa, Soh, Junichi, Futami, Junichiro, Putranto, Endy Widya, Hibino, Toshihiko, Nishibori, Masahiro, Toyooka, Shinichi, Sakaguchi, Masakiyo

“…Compiling evidence indicates an unusual role of extracellular S100A8/A9 in cancer metastasis. S100A8/A9 secreted from either cancer cells or normal cells…”
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Periostin in allergic inflammation by Izuhara, Kenji, Arima, Kazuhiko, Ohta, Shoichiro, Suzuki, Shoichi, Inamitsu, Masako, Yamamoto, Ken-ichi

“…Periostin, an extracellular matrix protein belonging to the fasciclin family, has been shown to play a critical role in the process of remodeling during…”
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Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer by Li, Chunning, Yoshimura, Teizo, Tian, Miao, Wang, Yuze, Kondo, Takamasa, Yamamoto, Ken-Ichi, Fujisawa, Masayoshi, Ohara, Toshiaki, Sakaguchi, Masakiyo, Matsukawa, Akihiro

“…Background Patients with triple-negative breast cancer (TNBC) often have poorer prognosis than those with other subtypes because of its aggressive behaviors…”
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Phosphorylated SARM1 is involved in the pathological process of rotenone-induced neurodegeneration by Murata, Hitoshi, Phoo, May Tha Zin, Ochi, Toshiki, Tomonobu, Nahoko, Yamamoto, Ken-ichi, Kinoshita, Rie, Miyazaki, Ikuko, Nishibori, Masahiro, Asanuma, Masato, Sakaguchi, Masakiyo

“…Abstract Sterile alpha and Toll/interleukin receptor motif-containing protein 1 (SARM1) is a NAD+ hydrolase that plays a key role in axonal degeneration and…”
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exSSSRs (extracellular S100 soil sensor receptors)‐Fc fusion proteins work as prominent decoys to S100A8/A9‐induced lung tropic cancer metastasis by Kinoshita, Rie, Sato, Hiroki, Yamauchi, Akira, Takahashi, Yuta, Inoue, Yusuke, Sumardika, I. Wayan, Chen, Youyi, Tomonobu, Nahoko, Araki, Kota, Shien, Kazuhiko, Tomida, Shuta, Torigoe, Hidejiro, Namba, Kei, Kurihara, Eisuke, Ogoshi, Yusuke, Murata, Hitoshi, Yamamoto, Ken‐ichi, Futami, Junichiro, Putranto, Endy Widya, Ruma, I. Made Winarsa, Yamamoto, Hiromasa, Soh, Junichi, Hibino, Toshihiko, Nishibori, Masahiro, Kondo, Eisaku, Toyooka, Shinichi, Sakaguchi, Masakiyo

“…Within the “seed and soil” theory of organ tropic cancer metastasis is a growing compilation of evidence that S100A8/A9 functions as a soil signal that…”
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Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion by Chen, Youyi, Sumardika, I Wayan, Tomonobu, Nahoko, Winarsa Ruma, I Made, Kinoshita, Rie, Kondo, Eisaku, Inoue, Yusuke, Sato, Hiroki, Yamauchi, Akira, Murata, Hitoshi, Yamamoto, Ken-ichi, Tomida, Shuta, Shien, Kazuhiko, Yamamoto, Hiromasa, Soh, Junichi, Liu, Ming, Futami, Junichiro, Sasai, Kaori, Katayama, Hiroshi, Kubo, Miyoko, Putranto, Endy Widya, Hibino, Toshihiko, Sun, Bei, Nishibori, Masahiro, Toyooka, Shinichi, Sakaguchi, Masakiyo

“…Since metastasis accounts for the majority of cancer-associated deaths, studies on the mechanisms of metastasis are needed to establish innovative strategies…”
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Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness by Chen, Youyi, Sumardika, I Wayan, Tomonobu, Nahoko, Kinoshita, Rie, Inoue, Yusuke, Iioka, Hidekazu, Mitsui, Yosuke, Saito, Ken, Ruma, I Made Winarsa, Sato, Hiroki, Yamauchi, Akira, Murata, Hitoshi, Yamamoto, Ken-ichi, Tomida, Shuta, Shien, Kazuhiko, Yamamoto, Hiromasa, Soh, Junichi, Futami, Junichiro, Kubo, Miyoko, Putranto, Endy Widya, Murakami, Takashi, Liu, Ming, Hibino, Toshihiko, Nishibori, Masahiro, Kondo, Eisaku, Toyooka, Shinichi, Sakaguchi, Masakiyo

“…Metastatic breast cancer is the leading cause of cancer-associated death in women. The progression of this fatal disease is associated with inflammatory…”
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Presence of Microplastics in Four Types of Shellfish Purchased at Fish Markets in Okayama City, Japan by Yamamoto, Kenichi, Oshiki, Toshiyuki, Kagawa, Hiroko, Namba, Masayoshi, Sakaguchi, Masakiyo

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Behavior of Non-metallic Inclusions in Steel during Hot Deformation and the Effects of Deformed Inclusions on Local Ductility by Yamamoto, Ken-ichi, Yamamura, Hideaki, Suwa, Yoshihiro

“…In order to clarify both the behavior of non-metallic inclusions during hot deformation and the effects of non-metallic inclusions on the local ductility of…”
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Histidine-Rich Glycoprotein Suppresses the S100A8/A9-Mediated Organotropic Metastasis of Melanoma Cells by Tomonobu, Nahoko, Kinoshita, Rie, Wake, Hidenori, Inoue, Yusuke, Ruma, I Made Winarsa, Suzawa, Ken, Gohara, Yuma, Komalasari, Ni Luh Gede Yoni, Jiang, Fan, Murata, Hitoshi, Yamamoto, Ken-ichi, Sumardika, I Wayan, Chen, Youyi, Futami, Junichiro, Yamauchi, Akira, Kuribayashi, Futoshi, Kondo, Eisaku, Toyooka, Shinichi, Nishibori, Masahiro, Sakaguchi, Masakiyo

“…The dissection of the complex multistep process of metastasis exposes vulnerabilities that could be exploited to prevent metastasis. To search for possible…”
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Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface by Takahashi, Tetta, Tomonobu, Nahoko, Kinoshita, Rie, Yamamoto, Ken-Ichi, Murata, Hitoshi, Komalasari, Ni Luh Gede Yoni, Chen, Youyi, Jiang, Fan, Gohara, Yuma, Ochi, Toshiki, Ruma, I Made Winarsa, Sumardika, I Wayan, Zhou, Jin, Honjo, Tomoko, Sakaguchi, Yoshihiko, Yamauchi, Akira, Kuribayashi, Futoshi, Kondo, Eisaku, Inoue, Yusuke, Futami, Junichiro, Toyooka, Shinichi, Zamami, Yoshito, Sakaguchi, Masakiyo

“…Our earlier research revealed that the secreted lysyl oxidase-like 4 (LOXL4) that is highly elevated in triple-negative breast cancer (TNBC) acts as a catalyst…”
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Signal Diversity of Receptor for Advanced Glycation End Products by Sakaguchi, Masakiyo, Kinoshita, Rie, Putranto, Endy Widya, Ruma, I Made Winarsa, Sumardika, I Wayan, Youyi, Chen, Tomonobu, Naoko, Yamamoto, Ken-Ichi, Murata, Hitoshi

“…The receptor for advanced glycation end products (RAGE) is involved in inflammatory pathogenesis. It functions as a receptor to multiple ligands such as AGEs,…”
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Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts by Mitsui, Yosuke, Tomonobu, Nahoko, Watanabe, Masami, Kinoshita, Rie, Sumardika, I Wayan, Youyi, Chen, Murata, Hitoshi, Yamamoto, Ken-ichi, Sadahira, Takuya, Rodrigo, Acosta Gonzalez Herik, Takamatsu, Hitoshi, Araki, Kota, Yamauchi, Akira, Yamamura, Masahiro, Fujiwara, Hideyo, Inoue, Yusuke, Futami, Junichiro, Saito, Ken, Iioka, Hidekazu, Kondo, Eisaku, Nishibori, Masahiro, Toyooka, Shinichi, Yamamoto, Yasuhiko, Nasu, Yasutomo, Sakaguchi, Masakiyo

“…S100A11, a member of the S100 family of proteins, is actively secreted from pancreatic ductal adenocarcinoma (PDAC) cells. However, the role of the…”
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Decrease in heart rate variability response to task is related to anxiety and depressiveness in normal subjects by Shinba, Toshikazu, Kariya, Nobutoshi, Matsui, Yasue, Ozawa, Nobuyuki, Matsuda, Yoshiki, Yamamoto, Ken‐ichi

“…Aims:  Previous studies have shown that heart rate variability (HRV) measurement is useful in investigating the pathophysiology of various psychiatric…”
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Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis by Arima, Kazuhiko, Ohta, Shoichiro, Takagi, Atsushi, Shiraishi, Hiroshi, Masuoka, Miho, Ontsuka, Kanako, Suto, Hajime, Suzuki, Shoichi, Yamamoto, Ken-ichi, Ogawa, Masahiro, Simmons, Olga, Yamaguchi, Yukie, Toda, Shuji, Aihara, Michiko, Conway, Simon J., Ikeda, Shigaku, Izuhara, Kenji

“…Epidermal hyperplasia is a histological hallmark observed in both atopic dermatitis (AD) and psoriasis, although the clinical features and the underlying…”
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