Search Results - "Yamamoto, Bryan K."
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Neurotoxicity of methamphetamine and 3,4-methylenedioxymethamphetamine
Published in Life sciences (1973) (27-02-2014)“…Amphetamines are a class of psychostimulant drugs that are widely abused for their stimulant, euphoric, empathogenic and hallucinogenic properties. Many of…”
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The Role of Oxidative Stress, Metabolic Compromise, and Inflammation in Neuronal Injury Produced by Amphetamine-Related Drugs of Abuse
Published in Journal of neuroimmune pharmacology (01-12-2008)“…Methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) are amphetamine derivatives with high abuse liability. These amphetamine-related…”
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Toxic Effects of Methamphetamine on Perivascular Health: Co-morbid Effects of Stress and Alcohol Use Disorders
Published in Current neuropharmacology (2021)“…Methamphetamine (Meth) abuse presents a global problem and commonly occurs with stress and/or alcohol use disorders. Regardless, the biological causes and…”
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Methamphetamine oxidatively damages parkin and decreases the activity of 26S proteasome in vivo
Published in Journal of neurochemistry (01-03-2011)“…J. Neurochem. (2011) 116, 1005-1017. ABSTRACT: Methamphetamine (METH) is toxic to dopaminergic (DAergic) terminals in animals and humans. An early event in…”
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Behavioral impairments and serotonin reductions in rats after chronic L-dopa
Published in Psychopharmacology (01-09-2015)“…Rationale L-dopa, the main therapeutic for Parkinson’s disease (PD), has been shown to increase brain dopamine concentrations that are necessary for proper…”
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Actions of 3,4-methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons
Published in Pharmacology, biochemistry and behavior (01-08-2008)“…3,4-Methylenedioxymethamphetamine (MDMA) is an amphetamine derivative and a popular drug of abuse that exhibits mild hallucinogenic and rewarding properties…”
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The impact of abstinence from chronic alcohol consumption on the mouse striatal proteome: sex and subregion-specific differences
Published in Frontiers in pharmacology (03-06-2024)“…Alcohol misuse is the third leading preventable cause of death in the world. The World Health Organization currently estimates that 1 in 20 deaths are directly…”
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Disruption of the Glutamate-Glutamine Cycle Involving Astrocytes in an Animal Model of Depression for Males and Females
Published in Frontiers in behavioral neuroscience (06-12-2016)“…Women are twice as likely as men to develop major depression. The brain mechanisms underlying this sex disparity are not clear. Disruption of the…”
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Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry
Published in eLife (16-03-2021)“…Despite the rising prevalence of methadone treatment in pregnant women with opioid use disorder, the effects of methadone on neurobehavioral development remain…”
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Protracted effects of chronic stress on serotonin-dependent thermoregulation
Published in Stress (Amsterdam, Netherlands) (02-11-2015)“…Chronic stress is known to affect serotonin (5HT) neurotransmission in the brain and to alter body temperature. The body temperature is controlled in part, by…”
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rapid oxidation and persistent decrease in the vesicular monoamine transporter 2 after methamphetamine
Published in Journal of neurochemistry (01-11-2007)“…Methamphetamine (METH) produces long-term decreases in markers of dopamine (DA) terminals in animals and humans. A decrease in the function of the vesicular…”
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Evaluation of Microglia/Macrophage Cells from Rat Striatum and Prefrontal Cortex Reveals Differential Expression of Inflammatory-Related mRNA after Methamphetamine
Published in Brain sciences (25-11-2019)“…RNA sequencing (RNAseq) can be a powerful tool in the identification of transcriptional changes after drug treatment. RNAseq was utilized to determine…”
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Interactions between methamphetamine and environmental stress: role of oxidative stress, glutamate and mitochondrial dysfunction
Published in Addiction (Abingdon, England) (01-04-2007)“…ABSTRACT Aims Methamphetamine is an amphetamine derivative that is abused increasingly world‐wide at an alarming rate over the last decade. Pre‐clinical and…”
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High-Dose Methamphetamine Acutely Activates the Striatonigral Pathway to Increase Striatal Glutamate and Mediate Long-Term Dopamine Toxicity
Published in The Journal of neuroscience (15-12-2004)“…Methamphetamine (METH) has been shown to increase the extracellular concentrations of both dopamine (DA) and glutamate (GLU) in the striatum. Dopamine,…”
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L-Dopa and Brain Serotonin System Dysfunction
Published in Toxics (Basel) (05-03-2015)“…L-dopa is used to treat the motor symptoms associated with Parkinson's disease, a neurodegenerative movement disorder characterized by a loss of dopamine…”
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Chronic stress enhances methamphetamine-induced extracellular glutamate and excitotoxicity in the rat striatum
Published in Synapse (New York, N.Y.) (01-05-2008)“…Striking parallels exist between the neurochemical and toxic effects of stress and methamphetamine. Despite these similarities, no studies have examined how…”
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Methamphetamine‐induced inhibition of mitochondrial complex II: roles of glutamate and peroxynitrite
Published in Journal of neurochemistry (01-10-2005)“…High‐dose methamphetamine (METH) is associated with long‐term deficits in dopaminergic systems. Although the mechanism(s) which contributes to these deficits…”
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Lobeline attenuates methamphetamine-induced changes in vesicular monoamine transporter 2 immunoreactivity and monoamine depletions in the striatum
Published in The Journal of pharmacology and experimental therapeutics (01-01-2005)“…L-Lobeline is an alkaloid that inhibits the behavioral effects of methamphetamine (METH) in rats. No studies have examined the effects of lobeline on the acute…”
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Amphetamine toxicities: classical and emerging mechanisms
Published in Annals of the New York Academy of Sciences (01-02-2010)“…The drugs of abuse, methamphetamine and MDMA, produce long-term decreases in markers of biogenic amine neurotransmission. These decreases have been…”
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Methamphetamine‐induced spectrin proteolysis in the rat striatum
Published in Journal of neurochemistry (01-03-2006)“…Methamphetamine (METH) is a widely abused psychostimulant. Multiple high doses of METH cause long‐term toxicity to dopamine (DA) and serotonin (5‐HT) nerve…”
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