Search Results - "Yamakuchi, Munekazu"

miR-34a Repression of SIRT1 Regulates Apoptosis by Yamakuchi, Munekazu, Ferlito, Marcella, Lowenstein, Charles J.

“…MicroRNA 34a (miR-34a) is a tumor suppressor gene, but how it regulates cell proliferation is not completely understood. We now show that the microRNA miR-34a…”
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MiR-34, SIRT1, and p53: The feedback loop by Yamakuchi, Munekazu, Lowenstein, Charles J.

“…MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression.  Several studies have linked dysregulation of miRNA with tumorigenesis.  The TP53…”
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MicroRNAs in Vascular Biology by Yamakuchi, Munekazu

“…Vascular inflammation is an important component of the pathophysiology of cardiovascular diseases, such as hypertension, atherosclerosis, and aneurysms. All…”
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MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1 by Harris, Tamia A, Yamakuchi, Munekazu, Ferlito, Marcella, Mendell, Joshua T, Lowenstein, Charles J

“…Adhesion molecules expressed by activated endothelial cells play a key role in regulating leukocyte trafficking to sites of inflammation. Resting endothelial…”
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P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis by Yamakuchi, Munekazu, Lotterman, Craig D, Bao, Clare, Hruban, Ralph H, Karim, Baktiar, Mendell, Joshua T, Huso, David, Lowenstein, Charles J

“…The pathway involving the tumor suppressor gene TP53 can regulate tumor angiogenesis by unclear mechanisms. Here we show that p53 regulates hypoxic signaling…”
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MicroRNA-22 regulates hypoxia signaling in colon cancer cells by Yamakuchi, Munekazu, Yagi, Shusuke, Ito, Takashi, Lowenstein, Charles J

“…MicroRNAs (MiRNAs) are short, non-coding RNA that regulate a variety of cellular functions by suppressing target protein expression. We hypothesized that a set…”
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SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor by Zhu, Qiuyu Martin, Zhu, Qiuyu, Yamakuchi, Munekazu, Lowenstein, Charles J

“…Endothelial exocytosis regulates vascular thrombosis and inflammation. The trafficking and release of endothelial vesicles is mediated by SNARE (Soluble NSF…”
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Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis by Chang, Tsung-Cheng, Wentzel, Erik A., Kent, Oliver A., Ramachandran, Kalyani, Mullendore, Michael, Lee, Kwang Hyuck, Feldmann, Georg, Yamakuchi, Munekazu, Ferlito, Marcella, Lowenstein, Charles J., Arking, Dan E., Beer, Michael A., Maitra, Anirban, Mendell, Joshua T.

“…The p53 tumor suppressor protein is a critical regulator of the cellular response to cancer-initiating insults such as genotoxic stress. In this report, we…”
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Application of high-mannose-type glycan-specific lectin from Oscillatoria Agardhii for affinity isolation of tumor-derived extracellular vesicles by Yamamoto, Mika, Harada, Yoichiro, Suzuki, Takehiro, Fukushige, Tomoko, Yamakuchi, Munekazu, Kanekura, Takuro, Dohmae, Naoshi, Hori, Kanji, Maruyama, Ikuro

“…Tumor cells secrete membrane vesicles of various sizes, termed extracellular vesicles (EVs), which have gained increasing attention as potential tumor…”
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Endothelial Cell Aging: How miRNAs Contribute? by Yamakuchi, Munekazu, Hashiguchi, Teruto

“…Endothelial cells (ECs) form monolayers and line the interior surfaces of blood vessels in the entire body. In most mammalian systems, the capacity of…”
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Evaluation of VEGF-A in platelet and microRNA-126 in serum after coronary artery bypass grafting by Mukaihara, Kosuke, Yamakuchi, Munekazu, Kanda, Hideaki, Shigehisa, Yoshiya, Arata, Kenichi, Matsumoto, Kazuhisa, Takenouchi, Kazunori, Oyama, Yoko, Koriyama, Toyoyasu, Hashiguchi, Teruto, Imoto, Yutaka

“…Platelet functions are thought to contribute to clinical outcomes after heart surgery. This study was conducted to assess the pivotal roles of vascular…”
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Ets-1 and Ets-2 Regulate the Expression of MicroRNA-126 in Endothelial Cells by Harris, Tamia A, Yamakuchi, Munekazu, Kondo, Maiko, Oettgen, Peter, Lowenstein, Charles J

“…OBJECTIVE—MicroRNA plays important roles in vascular biology, but the regulation of endothelial-specific microRNA is not well characterized. MicroRNA-126…”
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IL-13 enhances mesenchymal transition of pulmonary artery endothelial cells via down-regulation of miR-424/503 in vitro by Takagi, Koichi, Yamakuchi, Munekazu, Matsuyama, Takahiro, Kondo, Kiyotaka, Uchida, Akifumi, Misono, Shunsuke, Hashiguchi, Teruto, Inoue, Hiromasa

“…Pulmonary arterial hypertension (PAH) has a major effect on life expectancy with functional degeneracy of the lungs and right heart. Interleukin-13 (IL-13),…”
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VEGF-A165 is the predominant VEGF-A isoform in platelets, while VEGF-A121 is abundant in serum and plasma from healthy individuals by Yamakuchi, Munekazu, Okawa, Masashi, Takenouchi, Kazunori, Bibek, Aryal, Yamada, Shingo, Inoue, Keiichi, Higurashi, Kazuhiko, Tabaru, Akito, Tanoue, Kiyonori, Oyama, Yoko, Higashi, Sadayuki, Fujisaki, Chieko, Kanda, Hideaki, Terasaki, Hiroto, Sakamoto, Taiji, Soga, Yoshiharu, Hashiguchi, Teruto

“…Vascular endothelial growth factor A (VEGF-A) plays pivotal roles in regulating tumor angiogenesis as well as physiological vascular function. The major VEGF-A…”
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High‐fat diet exacerbates imiquimod‐induced psoriasis‐like dermatitis in mice by Higashi, Yuko, Yamakuchi, Munekazu, Fukushige, Tomoko, Ibusuki, Atsuko, Hashiguchi, Teruto, Kanekura, Takuro

“…Psoriasis, a chronic inflammatory skin disease, is closely related to systemic metabolism. An elevated body mass index (BMI) is a risk factor for psoriasis;…”
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HMGB1 is secreted by 3T3‐L1 adipocytes through JNK signaling and the secretion is partially inhibited by adiponectin by Shimizu, Toshiaki, Yamakuchi, Munekazu, Biswas, Kamal Krishna, Aryal, Bibek, Yamada, Shingo, Hashiguchi, Teruto, Maruyama, Ikuro

“…Objective Obesity is a chronic inflammatory disease, and adipocytes contribute to obesity‐associated inflammation by releasing inflammatory mediators. High…”
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1,5-Anhydro-D-fructose Protects against Rotenone-Induced Neuronal Damage In Vitro through Mitochondrial Biogenesis by Kasamo, Yuki, Kikuchi, Kiyoshi, Yamakuchi, Munekazu, Otsuka, Shotaro, Takada, Seiya, Kambe, Yuki, Ito, Takashi, Kawahara, Ko-ichi, Arita, Kazunori, Yoshimoto, Koji, Maruyama, Ikuro

“…Mitochondrial functional abnormalities or quantitative decreases are considered to be one of the most plausible pathogenic mechanisms of Parkinson’s disease…”
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Total atrial conduction time as a possible predictor of atrial fibrillation recurrence after catheter ablation for paroxysmal atrial fibrillation: relationship between electrical atrial remodeling and structural atrial remodeling time courses by Maenosono, Ryuichi, Mizukami, Naoko, Ichiki, Hitoshi, Oketani, Naoya, Namino, Fuminori, Masamoto, Izumi, Yuasa, Toshinori, Yamakuchi, Munekazu, Ohishi, Mitsuru, Hashiguchi, Teruto

“…Purpose Recently, the estimated total atrial conduction time measured using tissue Doppler imaging (PA-TDI duration) has been reported as a more accurate…”
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Endothelial senescence and microRNA by Yamakuchi Munekazu

“…Cellular senescence occurs when cells lose the ability to divide and proliferate. Endothelial cell senescence is associated with vascular diseases, such as…”
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Intra-platelet Serotonin as a Biomarker in HCC Recurrence: When Time Matters by Aryal, Bibek, Yamakuchi, Munekazu, Hashiguchi, Teruto, Imoto, Yutaka

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