Search Results - "Yamakawa, Natsuko"
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Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma
Published in Blood (07-06-2018)“…Epstein-Barr virus (EBV) causes various diseases in the elderly, including B-cell lymphoma such as Hodgkin's lymphoma and diffuse large B-cell lymphoma. Here,…”
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miRNAs in Normal and Malignant Hematopoiesis
Published in International journal of molecular sciences (11-07-2017)“…Lineage specification is primarily regulated at the transcriptional level and lineage-specific transcription factors determine cell fates. MicroRNAs (miRNAs)…”
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Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint
Published in The Journal of clinical investigation (01-11-2016)“…Patients with mutations in AICDA, which encodes activation-induced cytidine deaminase (AID), display an impaired peripheral B cell tolerance. AID mediates…”
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K1 gene transformation activities in AIDS-related and classic type Kaposi’s sarcoma: Correlation with clinical presentation
Published in Scientific reports (23-04-2019)“…Kaposi’s sarcoma-associated herpesvirus (KSHV) causes both AIDS-related Kaposi’s sarcoma (KS) and classic KS, but their clinical presentations are different,…”
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Small RNA as a regulator of hematopoietic development, immune response in infection and tumorigenesis
Published in International journal of hematology (01-05-2014)“…Posttranscriptional gene regulation by small RNAs (15–40-nucleotide noncoding RNAs) is now established as an important branch of the gene regulatory system. It…”
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Prime-boost-type PspA3 + 2 mucosal vaccine protects cynomolgus macaques from intratracheal challenge with pneumococci
Published in Inflammation and Regeneration (15-11-2023)“…Although vaccination is recommended for protection against invasive pneumococcal disease, the frequency of pneumococcal pneumonia is still high worldwide. In…”
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Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A
Published in International immunology (01-01-2013)“…A cell surface heterodimer Toll-like receptor 4 (TLR4)/MD-2 senses lipopolysaccharide (LPS), a principal membrane component of Gram-negative bacteria. LPS…”
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DNA display selection of peptide ligands for a full-length human G protein-coupled receptor on CHO-K1 cells
Published in PloS one (10-01-2012)“…The G protein-coupled receptors (GPCRs), which form the largest group of transmembrane proteins involved in signal transduction, are major targets of currently…”
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Pathogenesis and novel therapy for EBV-related B-cell lymphoma
Published in Rinshō ketsueki (01-01-2016)“…Epstein-Barr virus (EBV), a type of γ-herpes virus, is known to be a tumor virus. About 90% of adults were found to be persistently infected with EBV and this…”
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Intracellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes
Published in International immunology (01-08-2011)Get full text
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Structural Analyses of Human Toll-like Receptor 4 Polymorphisms D299G and T399I
Published in The Journal of biological chemistry (23-11-2012)“…Toll-like receptor 4 (TLR4) and its coreceptor MD-2 recognize bacterial lipopolysaccharide (LPS) and signal the innate immune response. Two single nucleotide…”
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Vaccination with Intradermal Bacillus Calmette-Guérin Provides Robust Protection against Extrapulmonary Tuberculosis but Not Pulmonary Infection in Cynomolgus Macaques
Published in The Journal of immunology (1950) (01-12-2020)“…Recently, the efficacy of bacillus Calmette-Guérin (BCG) vaccination is being reassessed in accordance with the achievements of clinical tuberculosis (TB)…”
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TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance
Published in The Journal of experimental medicine (04-12-2023)“…Central B cell tolerance is believed to be regulated by B cell receptor signaling induced by the recognition of self-antigens in immature B cells. Using…”
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Modulation of macrophages by tumor-derived secretary small RNAs is critical for EBV positive lymphoma formation
Published in Experimental hematology (01-09-2015)Get full text
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Intracellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes
Published in International immunology (01-08-2011)“…Toll-like receptor (TLR)4/MD-2, a sensor for LPS, delivers the MyD88-dependent signal from the cell surface, then traffics to endolysosomes and delivers the…”
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The Critical Interaction Between Epstein-Barr Virus (EBV) Positive B-Cells and Tumor Associated Macrophages (TAMs)
Published in Blood (06-12-2014)“…Introduction: EBV positive diffuse large B-cell lymphoma of the elderly (EBV positive DLBCL, elderly) has been newly categorized in 2008 WHO classification…”
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Novel functional small RNAs are selectively loaded onto mammalian Ago1
Published in Nucleic acids research (01-04-2014)“…Argonaute (Ago) proteins function in RNA silencing as components of the RNA-induced silencing complex (RISC). In lower organisms, the small interfering RNA and…”
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EBV-Encoded Mirnas Facilitate Inflammation and Tumor Formation Through Both Intra- and Inter-Cellular Regulation In Vivo Mouse Model
Published in Blood (15-11-2013)“…EB virus (EBV) is associated with heterogeneous lymphomas. Hodgkin's lymphoma (HL) cells are embedded in non-neoplastic bystanders: B, T cells, and…”
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Corrigendum: Germline hypomorphic CARD11 mutations in severe atopic disease
Published in Nature genetics (01-11-2017)“…This corrects the article DOI: 10.1038/ng.3898…”
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