Search Results - "Yamakawa, Naoki"

A2B adenosine receptor inhibition by the dihydropyridine calcium channel blocker nifedipine involves colonic fluid secretion by Asano, Teita, Noda, Yuto, Tanaka, Ken-Ichiro, Yamakawa, Naoki, Wada, Mitsuhito, Mashimo, Tadaaki, Fukunishi, Yoshifumi, Mizushima, Tohru, Takenaga, Mitsuko

“…The adenosine A 2B receptor is a critical protein in intestinal water secretion. In the present study, we screened compound libraries to identify inhibitors of…”
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Crystal face identification by Raman microscopy for assessment of crystal habit of a drug by Moriyama, Kei, Furuno, Naoko, Yamakawa, Naoki

“…[Display omitted] Crystal habit is one of the key crystallographic characteristics of active pharmaceutical ingredients (APIs), especially those that are…”
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Suppression of Alzheimer's disease-related phenotypes by geranylgeranylacetone in mice by Hoshino, Tatsuya, Suzuki, Koichiro, Matsushima, Takahide, Yamakawa, Naoki, Suzuki, Toshiharu, Mizushima, Tohru

“…Amyloid-β peptide (Aβ) plays an important role in the pathogenesis of Alzheimer's disease (AD). Aβ is generated by the secretase-mediated proteolysis of…”
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Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles by Ishihara, Tsutomu, Takeda, Miho, Sakamoto, Haruka, Kimoto, Ayumi, Kobayashi, Chisa, Takasaki, Naoko, Yuki, Kanae, Tanaka, Ken-ichiro, Takenaga, Mitsuko, Igarashi, Rie, Maeda, Taishi, Yamakawa, Naoki, Okamoto, Yoshinari, Otsuka, Masami, Ishida, Tatsuhiro, Kiwada, Hiroshi, Mizushima, Yutaka, Mizushima, Tohru

“…Purpose We recently developed prostaglandin E₁ (PGE₁)-encapsulated nanoparticles, prepared with a poly(lactide) homopolymer (PLA, Mw = 17,500) and monomethoxy…”
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Therapeutic effects of eperisone on pulmonary fibrosis via preferential suppression of fibroblast activity by Tanaka, Ken-ichiro, Shimoda, Mikako, Sugizaki, Toshifumi, Ikeda, Maki, Takafuji, Ayaka, Kawahara, Masahiro, Yamakawa, Naoki, Mizushima, Tohru

“…Although the exact pathogenesis of idiopathic pulmonary fibrosis (IPF) is still unknown, the transdifferentiation of fibroblasts into myofibroblasts and the…”
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Measurement of Piston Pin-Bore Oil Film Pressure under Engine Operation by Iwata, Takumi, Owashi, Michiyasu, Oikawa, Masakuni, Mihara, Yuji, Kobayashi, Kunihiko, Yamakawa, Naoki

“…Thin-film sensors were used to measure the oil film pressure distribution at the piston pin-bore interface in order to ascertain the stress distribution on the…”
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Acetaminophen-induced differentiation of human breast cancer stem cells and inhibition of tumor xenograft growth in mice by Takehara, Masaya, Hoshino, Tatsuya, Namba, Takushi, Yamakawa, Naoki, Mizushima, Tohru

“…We searched for drugs that induced a morphological change in breast cancer stem cell-like cells, and found that acetaminophen induces the morphological change…”
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Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease by Tanaka, Ken-Ichiro, Ishihara, Tomoaki, Sugizaki, Toshifumi, Kobayashi, Daisuke, Yamashita, Yasunobu, Tahara, Kayoko, Yamakawa, Naoki, Iijima, Kumiko, Mogushi, Kaoru, Tanaka, Hiroshi, Sato, Keizo, Suzuki, Hidekazu, Mizushima, Tohru

“…The clinical treatment of chronic obstructive pulmonary disease (COPD) requires not only an improvement of airflow by bronchodilation but also the suppression…”
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Suppression of UV-Induced Wrinkle Formation by Induction of HSP70 Expression in Mice by Matsuda, Minoru, Hoshino, Tatsuya, Yamakawa, Naoki, Tahara, Kayoko, Adachi, Hiroaki, Sobue, Gen, Maji, Daisuke, Ihn, Hironobu, Mizushima, Tohru

“…UV-induced wrinkle formation owing to the degeneration of the extracellular matrix (ECM) is a major dermatological problem in which abnormal activation of…”
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Structure–activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity by Yamakawa, Naoki, Suzuki, Koichiro, Yamashita, Yasunobu, Katsu, Takashi, Hanaya, Kengo, Shoji, Mitsuru, Sugai, Takeshi, Mizushima, Tohru

“…Non-steroidal anti-inflammatory drugs (NSAIDs) achieve their anti-inflammatory effect by inhibiting cyclooxygenase activity. We previously suggested that in…”
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Deuterium Isotope Effects on Hydrophobic Interactions:  The Importance of Dispersion Interactions in the Hydrophobic Phase by Turowski, Maciej, Yamakawa, Naoki, Meller, Jaroslaw, Kimata, Kazuhiro, Ikegami, Tohru, Hosoya, Ken, Tanaka, Nobuo, Thornton, Edward R

“…Hydrogen/deuterium isotope effects on hydrophobic binding were examined by means of reversed-phase chromatographic separation of protiated and deuterated…”
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Low Direct Cytotoxicity of Loxoprofen on Gastric Mucosal Cells by Yamakawa, Naoki, Suemasu, Shintaro, Kimoto, Ayumi, Arai, Yasuhiro, Ishihara, Tomoaki, Yokomizo, Kazumi, Okamoto, Yoshinari, Otsuka, Masami, Tanaka, Ken-ichiro, Mizushima, Tohru

“…Pro-drugs of non-steroidal anti-inflammatory drugs (NSAIDs), such as loxoprofen are widely used for clinical purposes because they are not so harmful to the…”
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HSP70 confers protection against indomethacin-induced lesions of the small intestine by Asano, Teita, Tanaka, Ken-Ichiro, Yamakawa, Naoki, Adachi, Hiroaki, Sobue, Gen, Goto, Hidemi, Takeuchi, Koji, Mizushima, Tohru

“…In line with improvements in diagnostic procedures to detect intestinal lesions, it has become clear that nonsteroidal anti-inflammatory drugs (NSAIDs) such as…”
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Identification of Mepenzolate Derivatives With Long-Acting Bronchodilatory Activity by Tanaka, Ken-Ichiro, Yamakawa, Naoki, Yamashita, Yasunobu, Asano, Teita, Kanda, Yuki, Takafuji, Ayaka, Kawahara, Masahiro, Takenaga, Mitsuko, Fukunishi, Yoshifumi, Mizushima, Tohru

“…The standard treatment for chronic obstructive pulmonary disease is a combination of anti-inflammatory drugs and bronchodilators. We recently found that…”
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Expression of 150-kDa oxygen-regulated protein (ORP150) stimulates bleomycin-induced pulmonary fibrosis and dysfunction in mice by Tanaka, Ken-Ichiro, Shirai, Ayano, Ito, Yosuke, Namba, Takushi, Tahara, Kayoko, Yamakawa, Naoki, Mizushima, Tohru

“…► ORP150 expression stimulates bleomycin-induced pulmonary fibrosis. ► ORP150 expression stimulates an increase in pulmonary myofibroblast number. ► ORP150…”
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Comparison of Pharmacokinetics between Loxoprofen and Its Derivative with Lower Ulcerogenic Activity, Fluoro-loxoprofen by Yamakawa, Naoki, Suemasu, Shintaro, Watanabe, Hiroshi, Tahara, Kayoko, Tanaka, Ken-ichiro, Okamoto, Yoshinari, Ohtsuka, Masami, Maruyama, Toru, Mizushima, Tohru

“…We recently reported that, compared to loxoprofen (LOX, an non-steroidal anti-inflammatory drug), the LOX derivative fluoro-loxoprofen (F-LOX) is less…”
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Superiority of pulmonary administration of mepenzolate bromide over other routes as treatment for chronic obstructive pulmonary disease by Tanaka, Ken-Ichiro, Kurotsu, Shota, Asano, Teita, Yamakawa, Naoki, Kobayashi, Daisuke, Yamashita, Yasunobu, Yamazaki, Hiroshi, Ishihara, Tomoaki, Watanabe, Hiroshi, Maruyama, Toru, Suzuki, Hidekazu, Mizushima, Tohru

“…We recently proposed that mepenzolate bromide (mepenzolate) would be therapeutically effective against chronic obstructive pulmonary disease (COPD) due to its…”
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Synthesis and biological evaluation of loxoprofen derivatives by Yamakawa, Naoki, Suemasu, Shintaro, Matoyama, Masaaki, Tanaka, Ken-ichiro, Katsu, Takashi, Miyata, Keishi, Okamoto, Yoshinari, Otsuka, Masami, Mizushima, Tohru

“…Non-steroidal anti-inflammatory drugs (NSAIDs) achieve their anti-inflammatory actions through an inhibitory effect on cyclooxygenase (COX). Two COX subtypes,…”
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Binding of cationic bis-porphyrins linked with p- or m-xylylenediamine and their zinc(II) complexes to duplex DNA by Ishikawa, Yoshinobu, Yamakawa, Naoki, Uno, Tadayuki

“…Spectroscopic, viscometric, and molecular docking analysis of binding of cationic bis-porphyrins linked with p- or m-xylylenediamine (H(2)pXy and H(2)mXy) and…”
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Prostaglandin E1-containing nanoparticles improve walking activity in an experimental rat model of intermittent claudication by Ishihara, Tomoaki, Yamashita, Yasunobu, Takasaki, Naoko, Yamamoto, Shuhei, Hayashi, Erika, Tahara, Kayoko, Takenaga, Mitsuko, Yamakawa, Naoki, Ishihara, Tsutomu, Kasahara, Tadashi, Mizushima, Tohru

“…Objectives Due to the low stability of lipid emulsions, a lipid emulsion of prostaglandin E1 (Lipo‐PGE1) necessitates daily intravenous drip infusions. To…”
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