Search Results - "Yamaguchi, Mitsuhiro"

Design, synthesis, and pharmacological evaluation of a novel series of hormone sensitive lipase inhibitor by Ogiyama, Tomoko, Yamaguchi, Mitsuhiro, Kurikawa, Nobuya, Honzumi, Shoko, Terayama, Koji, Nagaoka, Nobumi, Yamamoto, Yuka, Kimura, Takako, Sugiyama, Daisuke, Inoue, Shin-ichi

“…[Display omitted] HSL inhibition is a promising approach to the treatment of dyslipidemia. As a result of re-optimization of lead compound 2, we identified…”
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Synthesis and Structure–Activity Relationships of 2-Aminoacetamide Derivatives as Peroxisome Proliferator-Activated Receptor α/γ Dual Agonists by Shibata, Yoshihiro, Kagechika, Katsuji, Ota, Masahiro, Yamaguchi, Mitsuhiro, Setoguchi, Masaki, Kubo, Hideo, Chiba, Kiyoshi, Takano, Hiromichi, Akiyama, Chiyuki, Ono, Mayumi, Nishi, Mina, Usui, Hiroyuki

“…We describe the design, syntheses, and structure–activity relationships of novel zwitterionic compounds as nonthiazolidinedion-based peroxisome…”
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Synthesis and Structure–Activity Relationships of Novel Zwitterionic Compounds as Peroxisome Proliferator Activated Receptor α/γ Dual Agonists with Improved Physicochemical Properties by Shibata, Yoshihiro, Kagechika, Katsuji, Yamaguchi, Mitsuhiro, Yoshikawa, Kenji, Chiba, Kiyoshi, Takano, Hiromichi, Akiyama, Chiyuki, Ono, Mayumi, Nishi, Mina, Kubo, Hideo, Kobayashi, Yoshimasa, Usui, Hiroyuki

“…We describe herein the design, syntheses and structure–activity relationships (SAR) of novel zwitterionic compounds as non-thiazolidinedion (TZD) based…”
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Discovery of N-[(1 R,2 S,5 S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4- c]pyridine-2-carboxamide hydrochloride: A novel, potent and orally active direct inhibitor of factor Xa by Nagata, Tsutomu, Yoshino, Toshiharu, Haginoya, Noriyasu, Yoshikawa, Kenji, Nagamochi, Masatoshi, Kobayashi, Syozo, Komoriya, Satoshi, Yokomizo, Aki, Muto, Ryo, Yamaguchi, Mitsuhiro, Osanai, Ken, Suzuki, Makoto, Kanno, Hideyuki

“…In the early 1990’s, we reported on the low-molecular selective fXa inhibitor DX-9065a having two amidino groups. However, it had poor oral bioavailability due…”
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Potent Estrogenic Agonists Bearing Dicarba-closo-dodecaborane as a Hydrophobic Pharmacophore by ENDO, Yasuyuki, IIJIMA, Toru, YAMAKOSHI, Yuko, YAMAGUCHI, Mitsuhiro, FUKASAWA, Hiroshi, SHUDO, Koichi

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Recurrent and Progressive Abdominal Pain and Enteritis in a Japanese Patient with Paroxysmal Nocturnal Hemoglobinuria by Hino, Akihisa, Yamashita, Yukiko, Yamaguchi, Mitsuhiro, Azenishi, Yasuhiko

“…This case report describes a young male patient with recurrent abdominal pain persisting for more than 16 months. Clinical investigations showed signs of…”
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Synthesis and Structure-Activity Relationships of 2-Aminoacetamide Derivatives as Peroxisome Proliferator-Activated Receptor α/γ Dual Agonists by Yoshihiro Shibataa, Katsuji Kagechikaa, Masahiro Otaa, Mitsuhiro Yamaguchia, Masaki Setoguchia, Hideo Kubob, Kiyoshi Chibaa, Hiromichi Takanoa, Chiyuki Akiyamaa, Mayumi Onoa, Mina Nishia, Hiroyuki Usuia

“…We describe the design, syntheses, and structure-activity relationships of novel zwitterionic compounds as nonthiazolidinedion-based peroxisome…”
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Synthesis and Structure-Activity Relationships of Novel Zwitterionic Compounds as Peroxisome Proliferator Activated Receptor α/γ Dual Agonists with Improved Physicochemical Properties by Yoshihiro Shibataa, Katsuji Kagechikaa, Mitsuhiro Yamaguchia, Kenji Yoshikawaa, Kiyoshi Chibaa, Hiromichi Takanoa, Chiyuki Akiyamaa, Mayumi Onoa, Mina Nishia, Hideo Kubob, Yoshimasa Kobayashia, Hiroyuki Usuia

“…We describe herein the design, syntheses and structure-activity relationships (SAR) of novel zwitterionic compounds as non-thiazolidinedion (TZD) based…”
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Structural Relaxation of Amorphous Silicon-Germanium Alloys: Molecular-Dynamics Study by Ishimaru, Manabu, Yamaguchi, Mitsuhiro, Hirotsu, Yoshihiko

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Successful treatment with imatinib mesylate for Philadelphia chromosome-positive refractory acute myeloid leukemia by Yamaguchi, Mitsuhiro, Konishi, Ichiro

“…A 51-year-old man was diagnosed as having Philadelpha (Ph) chromosome-positive acute myeloid leukemia (AML) with major-BCR/ABL mRNA. He achieved complete…”
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Discovery of novel pyridazine derivatives as glucose transporter type 4 (GLUT4) translocation activators by Tsuji, Takashi, Yamaguchi, Mitsuhiro, Kuroyanagi, Junichi, Furuzono, Shinji, Konishi, Masahiro, Terayama, Koji, Tanaka, Jun, Saito, Motoko, Kobayashi, Yoshiyuki

“…[Display omitted] We report herein the synthesis and structure-activity relationships (SAR) of a series of pyridazine derivatives with the activation of…”
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Discovery of novel pyrrole derivatives as potent agonists for the niacin receptor GPR109A by Miyazawa, Yuriko, Yamaguchi, Takahiro, Yamaguchi, Mitsuhiro, Tago, Keiko, Tamura, Akihiro, Sugiyama, Daisuke, Aburatani, Takahide, Nishizawa, Tomohiro, Kurikawa, Nobuya, Kono, Keita

“…[Display omitted] Novel pyrrole derivatives were discovered as potent agonists of the niacin receptor, GPR109A. During the derivatization, compound 16 was…”
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Identification of a novel boronic acid as a potent, selective, and orally active hormone sensitive lipase inhibitor by Ogiyama, Tomoko, Yamaguchi, Mitsuhiro, Kurikawa, Nobuya, Honzumi, Shoko, Yamamoto, Yuka, Sugiyama, Daisuke, Inoue, Shinichi

“…[Display omitted] Hormone sensitive lipase (HSL) is an attractive therapeutic target of dyslipidemia. We designed and synthesized several compounds as…”
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Renoprotective effects of laxative linaclotide: Inhibition of acute kidney injury and fibrosis in a rat model of renal ischemia-reperfusion by Hitaka, Yukihiro, Isoyama, Naohito, Tsuji, Shunya, Honda, Takeshi, Nakayama, Yuki, Yamaguchi, Mitsuhiro, Nakamura, Kimihiko, Hirata, Hiroshi, Shiraishi, Koji, Asagiri, Masataka

“…Ischemia-reperfusion (I/R) leads to tissue damage in transplanted kidneys, resulting in acute kidney injury (AKI) and chronic graft dysfunction, which…”
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Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation by Ogiyama, Tomoko, Yamaguchi, Mitsuhiro, Kurikawa, Nobuya, Honzumi, Shoko, Yamamoto, Yuka, Sugiyama, Daisuke, Takakusa, Hideo, Inoue, Shin-ichi

“…[Display omitted] Hormone sensitive lipase (HSL) has emerged as an attractive target for the treatment of dyslipidemia. We previously reported compound 1 as a…”
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Enhancing Effect of Tumor Promoters, Phorbol Esters and Teleocidins on Nuclear Receptor-Mediated Transcription by FUKASAWA, Hiroshi, YAMAGUCHI, Mitsuhiro, HASHIMOTO, Yuichi, ENDO, Yasuyuki, SHUDO, Koichi

“…Interaction between a tumor promoter, 12-O- tetradecanoylphorbol 13-acetate (TPA), and ligands of nuclear receptors has been interpreted as the result of…”
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Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1) by Shibata, Yoshihiro, Kagechika, Katsuji, Yamaguchi, Mitsuhiro, Kubo, Hideo, Usui, Hiroyuki

“…The design, syntheses and structure–activity relationships (SAR) of novel zwitterionic compounds as non-thiazolidinedion (TZD) based peroxisome proliferator…”
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Design, synthesis and evaluation of novel zwitterionic compounds as PPAR[alpha]/[gamma] dual agonists (1) by Shibata, Yoshihiro, Kagechika, Katsuji, Yamaguchi, Mitsuhiro, Kubo, Hideo, Usui, Hiroyuki

“…We describe here the design, syntheses and structure-activity relationships (SAR) of novel zwitterionic compounds as non-thiazolidinedion (TZD) based…”
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ROLE OF THE HYDROPHOBIC MOIETY OF TUMOR PROMOTERS. SYNTHESIS AND ACTIVITY OF 9-ALKYLATED BENZOLACTAMS by ENDO, Yasuyuki, YAMAGUCHI, Mitsuhiro, HIRANO, Masaaki, SHUDO, Koichi

“…(-)-Benzolactam-V8-310 reproduces the active conformation and biological activity of teleocidins. Various sizes and shapes of alkyl groups on aromatic nucleus…”
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3β, 5α-DIHYDROXYCHOLESTAN-6-ONE EXISTS IN HUMAN BLOOD by YAMAGUCHI, Mitsuhiro, ENDO, Yasuyuki, SHIMIZU, Masato, YAMAMOTO, Keiko, YAMADA, Sachiko, SHUDO, Koichi

“…3β, 5α-Dihydroxycholestan-6-one was detected in fresh human plasma at the concentration of 14-44 ng/mL. The oxysterol binds specifically to phorbol ester…”
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