Search Results - "Yamada, Masahito"

Cerebral amyloid angiopathy: emerging concepts by Yamada, Masahito

“…Cerebral amyloid angiopathy (CAA) involves cerebrovascular amyloid deposition and is classified into several types according to the amyloid protein involved…”
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Polyphenols for the Prevention and Treatment of Cognitive Impairment: Polyphenols for Prevention and Treatment of Cognitive Impairment (SY(T7)9) by YAMADA, Masahito

“…Epidemiological studies have suggested that diets rich in polyphenols/phenolic compounds are associated with reduced risk of cognitive impairment and…”
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Developments of a population‐based prospective cohort study for dementia (the Nakajima study) and an educational program for dementia experts (the NINPRO) by Yamada, Masahito

“…Aging of population is rapidly growing in Japan and all over the world. To overcome problem associated with an increase of older people with dementia, we have…”
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Anti-Dementia Drugs (Anti-Alzheimer's Disease Drugs) by Yamada, Masahito

“…Alzheimer's disease (AD) treatment includes both non-pharmacological and pharmacological approaches. Current pharmacological approaches include symptomatic and…”
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Vitamin A and Alzheimer's disease by Ono, Kenjiro, Yamada, Masahito

“…The deposition of amyloid β‐protein (Aβ) in the brain is an invariant feature of Alzheimer's disease (AD). Vitamin A, which has been traditionally considered…”
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High-speed atomic force microscopy reveals structural dynamics of amyloid β1–42 aggregates by Watanabe-Nakayama, Takahiro, Ono, Kenjiro, Itami, Masahiro, Takahashi, Ryoichi, Teplow, David B., Yamada, Masahito

“…Aggregation of amyloidogenic proteins into insoluble amyloid fibrils is implicated in various neurodegenerative diseases. This process involves protein…”
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Low-n oligomers as therapeutic targets of Alzheimer's disease by Ono, Kenjiro, Yamada, Masahito

“…J. Neurochem. (2011) 117, 19-28. ABSTRACT: The pathogenesis of Alzheimer's disease involves the progressive accumulation of amyloid β-protein (Aβ). Recent…”
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Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer’s disease progression by Noguchi-Shinohara, Moeko, Ono, Kenjiro, Hamaguchi, Tsuyoshi, Nagai, Toshitada, Kobayashi, Shoko, Komatsu, Junji, Samuraki-Yokohama, Miharu, Iwasa, Kazuo, Yokoyama, Kunihiko, Nakamura, Hiroyuki, Yamada, Masahito

“…We conducted a randomized placebo-controlled double-blind 24-week trial using Melissa officinalis ( M. officinalis ) extract richly containing rosmarinic acid…”
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Neuropathology of Disorders Leading to Dementia by Sakai, Kenji, Yamada, Masahito

“…Dementia is characterized by acquired cognitive dysfunction caused by various neurological disorders. Many neurological conditions can cause dementia,…”
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Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy by Kovacs, Gabor G., Ferrer, Isidro, Grinberg, Lea T., Alafuzoff, Irina, Attems, Johannes, Budka, Herbert, Cairns, Nigel J., Crary, John F., Duyckaerts, Charles, Ghetti, Bernardino, Halliday, Glenda M., Ironside, James W., Love, Seth, Mackenzie, Ian R., Munoz, David G., Murray, Melissa E., Nelson, Peter T., Takahashi, Hitoshi, Trojanowski, John Q., Ansorge, Olaf, Arzberger, Thomas, Baborie, Atik, Beach, Thomas G., Bieniek, Kevin F., Bigio, Eileen H., Bodi, Istvan, Dugger, Brittany N., Feany, Mel, Gelpi, Ellen, Gentleman, Stephen M., Giaccone, Giorgio, Hatanpaa, Kimmo J., Heale, Richard, Hof, Patrick R., Hofer, Monika, Hortobágyi, Tibor, Jellinger, Kurt, Jicha, Gregory A., Ince, Paul, Kofler, Julia, Kövari, Enikö, Kril, Jillian J., Mann, David M., Matej, Radoslav, McKee, Ann C., McLean, Catriona, Milenkovic, Ivan, Montine, Thomas J., Murayama, Shigeo, Lee, Edward B., Rahimi, Jasmin, Rodriguez, Roberta D., Rozemüller, Annemieke, Schneider, Julie A., Schultz, Christian, Seeley, William, Seilhean, Danielle, Smith, Colin, Tagliavini, Fabrizio, Takao, Masaki, Thal, Dietmar Rudolf, Toledo, Jon B., Tolnay, Markus, Troncoso, Juan C., Vinters, Harry V., Weis, Serge, Wharton, Stephen B., White, Charles L., Wisniewski, Thomas, Woulfe, John M., Yamada, Masahito, Dickson, Dennis W.

“…Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its…”
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Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion by Atarashi, Ryuichiro, Satoh, Katsuya, Sano, Kazunori, Fuse, Takayuki, Yamaguchi, Naohiro, Ishibashi, Daisuke, Matsubara, Takehiro, Nakagaki, Takehiro, Yamanaka, Hitoki, Shirabe, Susumu, Yamada, Masahito, Mizusawa, Hidehiro, Kitamoto, Tetsuyuki, Klug, Genevieve, McGlade, Amelia, Collins, Steven J, Nishida, Noriyuki

“…The development of technologies for the in vitro amplification of abnormal conformations of prion protein (PrPSc) has generated the potential for sensitive…”
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Predicting cerebral amyloid angiopathy-related intracerebral hemorrhages and other cerebrovascular disorders in Alzheimer's disease by Yamada, Masahito

“…Cerebral amyloid angiopathy (CAA) of amyloid β-protein (Aβ) type is common in Alzheimer's disease (AD). Aβ immunotherapies have been reported to induce…”
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Myricetin prevents high molecular weight Aβ1-42 oligomer-induced neurotoxicity through antioxidant effects in cell membranes and mitochondria by Kimura, Atsushi Michael, Tsuji, Mayumi, Yasumoto, Taro, Mori, Yukiko, Oguchi, Tatsunori, Tsuji, Yuya, Umino, Masakazu, Umino, Asami, Nishikawa, Toru, Nakamura, Shiro, Inoue, Tomio, Kiuchi, Yuji, Yamada, Masahito, Teplow, David B., Ono, Kenjiro

“…Excessive accumulation of amyloid β-protein (Aβ) is one of the primary mechanisms that leads to neuronal death with phosphorylated tau in the pathogenesis of…”
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The Spectrum of Cerebral Amyloid Angiopathy-related Disorders by Yamada, Masahito

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Methionine homozygosity for PRNP polymorphism and susceptibility to human prion diseases by Kosami, Koki, Ae, Ryusuke, Hamaguchi, Tsuyoshi, Sanjo, Nobuo, Tsukamoto, Tadashi, Kitamoto, Tetsuyuki, Yamada, Masahito, Mizusawa, Hidehiro, Nakamura, Yosikazu

“…BackgroundNo studies have assessed the independent association of methionine homozygosity at codon 129 with the susceptibility to prion diseases, controlling…”
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Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline by Noguchi-Shinohara, Moeko, Yuki, Sohshi, Dohmoto, Chiaki, Ikeda, Yoshihisa, Samuraki, Miharu, Iwasa, Kazuo, Yokogawa, Masami, Asai, Kimiko, Komai, Kiyonobu, Nakamura, Hiroyuki, Yamada, Masahito

“…Our objective was to determine whether the consumption of green tea, coffee, or black tea influences the incidence of dementia and mild cognitive impairment…”
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Natural Phenolic Compounds as Therapeutic and Preventive Agents for Cerebral Amyloidosis by Yamada, Masahito, Ono, Kenjiro, Hamaguchi, Tsuyoshi, Noguchi-Shinohara, Moeko

“…Epidemiological studies have suggested that diets rich in phenolic compounds may have preventive effects on the development of dementia or Alzheimer's disease…”
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Effects of Melissa officinalis Extract Containing Rosmarinic Acid on Cognition in Older Adults Without Dementia: A Randomized Controlled Trial by Noguchi-Shinohara, Moeko, Hamaguchi, Tsuyoshi, Sakai, Kenji, Komatsu, Junji, Iwasa, Kazuo, Horimoto, Mai, Nakamura, Hiroyuki, Yamada, Masahito, Ono, Kenjiro

“…Previous in vitro and in vivo studies on Alzheimer's disease (AD) models have reported that rosmarinic acid (RA) can inhibit the formation of amyloid-β fibrils…”
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Variants in saposin D domain of prosaposin gene linked to Parkinson's disease by Oji, Yutaka, Hatano, Taku, Ueno, Shin-Ichi, Funayama, Manabu, Ishikawa, Kei-Ichi, Okuzumi, Ayami, Noda, Sachiko, Sato, Shigeto, Satake, Wataru, Toda, Tatsushi, Li, Yuanzhe, Hino-Takai, Tomoko, Kakuta, Soichiro, Tsunemi, Taiji, Yoshino, Hiroyo, Nishioka, Kenya, Hattori, Tatsuya, Mizutani, Yasuaki, Mutoh, Tatsuro, Yokochi, Fusako, Ichinose, Yuta, Koh, Kishin, Shindo, Kazumasa, Takiyama, Yoshihisa, Hamaguchi, Tsuyoshi, Yamada, Masahito, Farrer, Matthew J, Uchiyama, Yasuo, Akamatsu, Wado, Wu, Yih-Ru, Matsuda, Junko, Hattori, Nobutaka

“…Recently, the genetic variability in lysosomal storage disorders has been implicated in the pathogenesis of Parkinson's disease. Here, we found that variants…”
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Age at onset in genetic prion disease and the design of preventive clinical trials by Minikel, Eric Vallabh, Vallabh, Sonia M, Orseth, Margaret C, Brandel, Jean-Philippe, Haïk, Stéphane, Laplanche, Jean-Louis, Zerr, Inga, Parchi, Piero, Capellari, Sabina, Safar, Jiri, Kenny, Janna, Fong, Jamie C, Takada, Leonel T, Ponto, Claudia, Hermann, Peter, Knipper, Tobias, Stehmann, Christiane, Kitamoto, Tetsuyuki, Ae, Ryusuke, Hamaguchi, Tsuyoshi, Sanjo, Nobuo, Tsukamoto, Tadashi, Mizusawa, Hidehiro, Collins, Steven J, Chiesa, Roberto, Roiter, Ignazio, de Pedro-Cuesta, Jesús, Calero, Miguel, Geschwind, Michael D, Yamada, Masahito, Nakamura, Yosikazu, Mead, Simon

“…OBJECTIVETo determine whether preventive trials in genetic prion disease could be designed to follow presymptomatic mutation carriers to onset of disease…”
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