Search Results - "Yamada, Kelvin A."

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH by Satoh, Akiko, Brace, Cynthia S., Rensing, Nick, Cliften, Paul, Wozniak, David F., Herzog, Erik D., Yamada, Kelvin A., Imai, Shin-ichiro

“…The mammalian Sir2 ortholog Sirt1 plays an important role in metabolic regulation. However, the role of Sirt1 in the regulation of aging and longevity is still…”
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The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway by McDaniel, Sharon S., Rensing, Nicholas R., Thio, Liu Lin, Yamada, Kelvin A., Wong, Michael

“…Summary The ketogenic diet (KD) is an effective treatment for epilepsy, but its mechanisms of action are poorly understood. We investigated the hypothesis that…”
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Obesity and Hypertriglyceridemia Produce Cognitive Impairment by Farr, Susan A, Yamada, Kelvin A, Butterfield, D. Allan, Abdul, H. Mohammad, Xu, Lin, Miller, Nicole E, Banks, William A, Morley, John E

“…Obesity is associated with cognitive impairments. Long-term mechanisms for this association include consequences of hyperglycemia, dyslipidemia, or other…”
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Ghrelin controls hippocampal spine synapse density and memory performance by Horvath, Tamas L, Diano, Sabrina, Farr, Susan A, Benoit, Stephen C, McNay, Ewan C, da Silva, Ivaldo, Horvath, Balazs, Gaskin, F Spencer, Nonaka, Naoko, Jaeger, Laura B, Banks, William A, Morley, John E, Pinto, Shirly, Sherwin, Robert S, Xu, Lin, Yamada, Kelvin A, Sleeman, Mark W, Tschöp, Matthias H

“…The gut hormone and neuropeptide ghrelin affects energy balance and growth hormone release through hypothalamic action that involves synaptic plasticity in the…”
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Calorie restriction and glucose regulation by Yamada, Kelvin A.

“…Summary Ketogenic diets (KDs) are effective treatments for epilepsy. The mechanisms of action are poorly understood. In some experimental seizure models,…”
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FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons by Shakkottai, Vikram G, Xiao, Maolei, Xu, Lin, Wong, Michael, Nerbonne, Jeanne M, Ornitz, David M, Yamada, Kelvin A

“…Abstract A missense mutation in the fibroblast growth factor 14 ( FGF14 ) gene underlies SCA27, an autosomal dominant spinocerebellar ataxia in humans. Mice…”
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Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14 by Wozniak, David F, Xiao, Maolei, Xu, Lin, Yamada, Kelvin A, Ornitz, David M

“…Abstract Spinocerebellar ataxia 27 (SCA27) is a recently described syndrome characterized by impaired cognitive abilities and a slowly progressive ataxia…”
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Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex by Zeng, Ling-Hui, Ouyang, Yannan, Gazit, Vered, Cirrito, John R, Jansen, Laura A, Ess, Kevin C, Yamada, Kelvin A, Wozniak, David F, Holtzman, David M, Gutmann, David H, Wong, Michael

“…Abstract Mice with inactivation of the Tuberous sclerosis complex-1 ( Tsc1 ) gene in glia ( Tsc1GFAP CKO mice) have deficient astrocyte glutamate transporters…”
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Leptin contributes to slower weight gain in juvenile rodents on a ketogenic diet by LIU LIN THIO, ERBAYAT-ALTAY, Ebru, RENSING, Nicholas, YAMADA, Kelvin A

“…The ketogenic diet (KD) is an efficacious therapy for medically refractory childhood epilepsy that also slows weight gain. We tested the hypothesis that the KD…”
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Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model by Wong, Michael, Ess, Kevin C., Uhlmann, Erik J., Jansen, Laura A., Li, Wen, Crino, Peter B., Mennerick, Steven, Yamada, Kelvin A., Gutmann, David H.

“…Excessive astrocytosis in cortical tubers in tuberous sclerosis complex (TSC) suggests that astrocytes may be important for epileptogenesis in TSC. We…”
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In vivo imaging of dendritic spines during electrographic seizures by Rensing, Nicholas, Ouyang, Yannan, Yang, Xiao-Feng, Yamada, Kelvin A., Rothman, Steven M., Wong, Michael

“…Epilepsy is associated with significant neurological morbidity, including learning disabilities, motor deficits, and behavioral problems. Although the causes…”
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A physiological role for amyloid-beta protein:enhancement of learning and memory by Morley, John E, Farr, Susan A, Banks, William A, Johnson, Steven N, Yamada, Kelvin A, Xu, Lin

“…Amyloid-beta protein (Abeta) is well recognized as having a significant role in the pathogenesis of Alzheimer's disease (AD). The reason for the presence of…”
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Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo by Cirrito, John R., Yamada, Kelvin A., Finn, Mary Beth, Sloviter, Robert S., Bales, Kelly R., May, Patrick C., Schoepp, Darryle D., Paul, Steven M., Mennerick, Steven, Holtzman, David M.

“…Aggregation of the amyloid-β (Aβ) peptide in the extracellular space of the brain is central to Alzheimer's disease pathogenesis. Aβ aggregation is…”
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Prevalence of Sleep Disturbances in Children With Neurofibromatosis Type 1 by Licis, Amy K., Vallorani, Alicia, Gao, Feng, Chen, Cynthia, Lenox, Jason, Yamada, Kelvin A., Duntley, Stephen P., Gutmann, David H.

“…Children with neurodevelopmental disorders are at increased risk for sleep issues, which affect quality of life, cognitive function, and behavior. To determine…”
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Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents by Xu, Lin, Rensing, Nicholas, Yang, Xiao-Feng, Zhang, Hai Xia, Thio, Liu Lin, Rothman, Steven M, Weisenfeld, Aryan E, Wong, Michael, Yamada, Kelvin A

“…Leptin is a hormone that reduces excitability in some hypothalamic neurons via leptin receptor activation of the JAK2 and PI3K intracellular signaling…”
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Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ ob mice by Erbayat-Altay, Ebru, Yamada, Kelvin A., Wong, Michael, Thio, Liu Lin

“…Leptin modulates multiple ion channels making its net effect on brain excitability difficult to predict. One method of determining leptin's net effect on brain…”
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A ketogenic diet does not impair rat behavior or long‐term potentiation by Thio, Liu Lin, Rensing, Nicholas, Maloney, Susan, Wozniak, David F., Xiong, Chengjie, Yamada, Kelvin A.

“…Summary The effect of the ketogenic diet on behavior and cognition is unclear. We addressed this issue in rats behaviorally and electrophysiologically. We fed…”
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Ketogenic diet reduces hypoglycemia-induced neuronal death in young rats by Yamada, Kelvin A., Rensing, Nicholas, Thio, Liu Lin

“…Hypoglycemia is an important complication of insulin treatment in diabetic children and may contribute to lasting cognitive impairment. Previous studies…”
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Repetitive hypoglycemia in young rats impairs hippocampal long-term potentiation by YAMADA, Kelvin A, RENSING, Nicholas, IZUMI, Yukitoshi, DE ERAUSQUIN, Gabriel A, GAZIT, Vered, DORSEY, David A, HERRERA, Daniel G

“…Mechanisms underlying cognitive dysfunction in young diabetic children are poorly understood, and may include synaptic dysfunction from insulin-induced…”
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An animal model of generalized nonconvulsive status epilepticus: immediate characteristics and long-term effects by WONG, Michael, WOZNIAK, David F, YAMADA, Kelvin A

“…Absence seizures are traditionally believed to have no significant long-term neurological consequences, but few basic scientific studies have examined the…”
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