Search Results - "Yam, Patricia T."

Signaling mechanisms of non-conventional axon guidance cues: the Shh, BMP and Wnt morphogens by Yam, Patricia T, Charron, Frédéric

“…Highlights • The morphogens Shh, BMPs and Wnts are also axon guidance molecules. • Shh, BMPs and Wnts do not guide axons via their canonical signaling…”
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Long-Range Guidance of Spinal Commissural Axons by Netrin1 and Sonic Hedgehog from Midline Floor Plate Cells by Wu, Zhuhao, Makihara, Shirin, Yam, Patricia T., Teo, Shaun, Renier, Nicolas, Balekoglu, Nursen, Moreno-Bravo, Juan Antonio, Olsen, Olav, Chédotal, Alain, Charron, Frédéric, Tessier-Lavigne, Marc

“…An important model for axon pathfinding is provided by guidance of embryonic commissural axons from dorsal spinal cord to ventral midline floor plate (FP). FP…”
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14-3-3 Proteins Regulate a Cell-Intrinsic Switch from Sonic Hedgehog-Mediated Commissural Axon Attraction to Repulsion after Midline Crossing by Yam, Patricia T., Kent, Christopher B., Morin, Steves, Farmer, W. Todd, Alchini, Ricardo, Lepelletier, Léa, Colman, David R., Tessier-Lavigne, Marc, Fournier, Alyson E., Charron, Frédéric

“…Axons must switch responsiveness to guidance cues during development for correct pathfinding. Sonic Hedgehog (Shh) attracts spinal cord commissural axons…”
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Sonic Hedgehog Guides Axons through a Noncanonical, Src-Family-Kinase-Dependent Signaling Pathway by Yam, Patricia T., Langlois, Sébastien D., Morin, Steves, Charron, Frédéric

“…Sonic hedgehog (Shh) plays essential roles in developmental events such as cell fate specification and axon guidance. Shh induces cell fate specification…”
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Polarized Dock Activity Drives Shh-Mediated Axon Guidance by Makihara, Shirin, Morin, Steves, Ferent, Julien, Côté, Jean-François, Yam, Patricia T., Charron, Frédéric

“…In the developing spinal cord, Sonic hedgehog (Shh) attracts commissural axons toward the floorplate. How Shh regulates the cytoskeletal remodeling that…”
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Integration of shallow gradients of Shh and Netrin-1 guides commissural axons by Sloan, Tyler F W, Qasaimeh, Mohammad A, Juncker, David, Yam, Patricia T, Charron, Frédéric

“…During nervous system development, gradients of Sonic Hedgehog (Shh) and Netrin-1 attract growth cones of commissural axons toward the floor plate of the…”
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Boc Acts via Numb as a Shh-Dependent Endocytic Platform for Ptch1 Internalization and Shh-Mediated Axon Guidance by Ferent, Julien, Giguère, Fanny, Jolicoeur, Christine, Morin, Steves, Michaud, Jean-Francois, Makihara, Shirin, Yam, Patricia T., Cayouette, Michel, Charron, Frederic

“…During development, Shh attracts commissural axons toward the floor plate through a non-canonical, transcription-independent signaling pathway that…”
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Cellular Functions of the Autism Risk Factor PTCHD1 in Mice by Tora, David, Gomez, Andrea M, Michaud, Jean-Francois, Yam, Patricia T, Charron, Frédéric, Scheiffele, Peter

“…The gene ( ) is mutated in patients with autism spectrum disorders and intellectual disabilities and has been hypothesized to contribute to Sonic hedgehog…”
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The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance by Ferent, Julien, Constable, Sandii, Gigante, Eduardo D., Yam, Patricia T., Mariani, Laura E., Legué, Emilie, Liem, Karel F., Caspary, Tamara, Charron, Frédéric

“…The small GTPase Arl13b is enriched in primary cilia and regulates Sonic hedgehog (Shh) signaling. During neural development, Shh controls patterning and…”
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Numb positively regulates Hedgehog signaling at the ciliary pocket by Liu, Xiaoliang, Yam, Patricia T., Schlienger, Sabrina, Cai, Eva, Zhang, Jingyi, Chen, Wei-Ju, Torres Gutierrez, Oscar, Jimenez Amilburu, Vanesa, Ramamurthy, Vasanth, Ting, Alice Y., Branon, Tess C., Cayouette, Michel, Gen, Risako, Marks, Tessa, Kong, Jennifer H., Charron, Frédéric, Ge, Xuecai

“…Hedgehog (Hh) signaling relies on the primary cilium, a cell surface organelle that serves as a signaling hub for the cell. Using proximity labeling and…”
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Sonic Hedgehog Guides Axons via Zipcode Binding Protein 1-Mediated Local Translation by Lepelletier, Léa, Langlois, Sébastien D, Kent, Christopher B, Welshhans, Kristy, Morin, Steves, Bassell, Gary J, Yam, Patricia T, Charron, Frédéric

“…Sonic hedgehog (Shh) attracts spinal cord commissural axons toward the floorplate. How Shh elicits changes in the growth cone cytoskeleton that drive growth…”
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Actin-myosin network reorganization breaks symmetry at the cell rear to spontaneously initiate polarized cell motility by Yam, Patricia T, Wilson, Cyrus A, Ji, Lin, Hebert, Benedict, Barnhart, Erin L, Dye, Natalie A, Wiseman, Paul W, Danuser, Gaudenz, Theriot, Julie A

“…We have analyzed the spontaneous symmetry breaking and initiation of actin-based motility in keratocytes (fish epithelial cells). In stationary keratocytes,…”
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N-cadherin relocalizes from the periphery to the center of the synapse after transient synaptic stimulation in hippocampal neurons by Yam, Patricia T, Pincus, Zachary, Gupta, Gagan D, Bashkurov, Mikhail, Charron, Frédéric, Pelletier, Laurence, Colman, David R

“…N-cadherin is a cell adhesion molecule which is enriched at synapses. Binding of N-cadherin molecules to each other across the synaptic cleft has been…”
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14-3-3 proteins regulate protein kinase a activity to modulate growth cone turning responses by Kent, Christopher B, Shimada, Tadayuki, Ferraro, Gino B, Ritter, Brigitte, Yam, Patricia T, McPherson, Peter S, Charron, Frédéric, Kennedy, Timothy E, Fournier, Alyson E

“…Growth cones regulate the speed and direction of neuronal outgrowth during development and regeneration. How the growth cone spatially and temporally regulates…”
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β-arrestins Are Scaffolding Proteins Required for Shh-Mediated Axon Guidance by Sauvé, Rachelle, Morin, Steves, Yam, Patricia T, Charron, Frédéric

“…During nervous system development, Sonic hedgehog (Shh) guides developing commissural axons toward the floor plate of the spinal cord. To guide axons, Shh…”
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Extracellular phosphorylation in axon pathfinding by Yam, Patricia T., Charron, Frederic

“…The growth and guidance of axons dictate their trajectories and are critical for neural-circuit formation. Research in this issue uncovers a new mechanism for…”
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Intracellular fluid flow in rapidly moving cells by Mogilner, Alex, Yam, Patricia T, Kinkhabwala, Anika, Keren, Kinneret, Theriot, Julie A

“…Cytosolic fluid dynamics have been implicated in cell motility because of the hydrodynamic forces they induce and because of their influence on transport of…”
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Myosin II contributes to cell-scale actin network treadmilling through network disassembly by Wilson, Cyrus A., Tsuchida, Mark A., Allen, Greg M., Barnhart, Erin L., Applegate, Kathryn T., Yam, Patricia T., Ji, Lin, Keren, Kinneret, Danuser, Gaudenz, Theriot, Julie A.

“…Myosin II in cell motility In animals, most cells when on the move migrate using a crawling motion, in which the front of the cell is propelled forward by the…”
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A human DCC variant causing mirror movement disorder reveals that the WAVE regulatory complex mediates axon guidance by netrin-1-DCC by Chaudhari, Karina, Zhang, Kaiyue, Yam, Patricia T, Zang, Yixin, Kramer, Daniel A, Gagnon, Sarah, Schlienger, Sabrina, Calabretta, Sara, Michaud, Jean-Francois, Collins, Meagan, Wang, Junmei, Srour, Myriam, Chen, Baoyu, Charron, Frédéric, Bashaw, Greg J

“…The axon guidance cue netrin-1 signals through its receptor DCC (deleted in colorectal cancer) to attract commissural axons to the midline. Variants in DCC are…”
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Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor control by Schlienger, Sabrina, Yam, Patricia T, Balekoglu, Nursen, Ducuing, Hugo, Michaud, Jean-Francois, Makihara, Shirin, Kramer, Daniel K, Chen, Baoyu, Fasano, Alfonso, Berardelli, Alfredo, Hamdan, Fadi F, Rouleau, Guy A, Srour, Myriam, Charron, Frederic

“…Mirror movements (MM) disorder is characterized by involuntary movements on one side of the body that mirror intentional movements on the opposite side. We…”
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