Search Results - "Yallop, Christopher"
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First-in-human randomized controlled trial of an oral, replicating adenovirus 26 vector vaccine for HIV-1
Published in PloS one (14-11-2018)“…Live, attenuated viral vectors that express HIV-1 antigens are being investigated as an approach to generating durable immune responses against HIV-1 in…”
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Formulation development of a live attenuated human rotavirus (RV3-BB) vaccine candidate for use in low- and middle-income countries
Published in Human vaccines & immunotherapeutics (03-07-2021)“…Formulation development was performed with the live, attenuated, human neonatal rotavirus vaccine candidate (RV3-BB) with three main objectives to facilitate…”
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Challenges in manufacturing adenoviral vectors for global vaccine product deployment
Published in Human gene therapy (01-04-2014)“…Abstract Once adenovirus vector-based vaccines are licensed for the prevention of important infectious diseases, manufacturing processes capable of reliably…”
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High throughput AS LNA qPCR method for the detection of a specific mutation in poliovirus vaccine strains
Published in Vaccine (02-04-2024)“…•AS LNA qPCR can accurately identify VP1-E295K containing samples in sPV2 batches.•The developed AS LNA qPCR for E295K mutation is highly sensitive.•LNA probes…”
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Developing a manufacturing process to deliver a cost effective and stable liquid human rotavirus vaccine
Published in Vaccine (08-04-2021)“…•A low-cost manufacturing process for a neonatal rotavirus vaccine was developed.•The formulation process developed resulted in a stable liquid vaccine at…”
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Modeling the long-term 2-8 °C stability profiles of a live, rotavirus vaccine candidate (RV3-BB) in various liquid formulations via extrapolations of real-time and accelerated stability data
Published in Biologicals (01-01-2022)“…To accelerate the formulation development of live-virus vaccine (LVV) candidates, more rapid approaches to rank-order formulations and estimate their real-time…”
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The effects of G418 on the growth and metabolism of recombinant mammalian cell lines
Published in Cytotechnology (Dordrecht) (01-03-2001)“…It is widely reported that the growth of recombinant bacteria and yeast is adversely affected by increased metabolic load caused by the maintenance of plasmid…”
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