Search Results - "Yalamanchili, Padmaja"

Molecular Imaging of Matrix Metalloproteinase in Atherosclerotic Lesions by Fujimoto, Shinichiro, MD, PhD, Hartung, Dagmar, MD, Ohshima, Satoru, MD, PhD, Edwards, D. Scott, PhD, Zhou, Jun, MD, Yalamanchili, Padmaja, PhD, Azure, Michael, PhD, Fujimoto, Ai, MD, PhD, Isobe, Satoshi, MD, PhD, Matsumoto, Yuji, MD, PhD, Boersma, Hendricus, PharmD, PhD, Wong, Nathan, PhD, Yamazaki, Junichi, MD, Narula, Navneet, MD, Petrov, Artiom, PhD, Narula, Jagat, MD, PhD, FACC

“…Objectives This study sought to evaluate the feasibility of noninvasive detection of matrix metalloproteinase (MMP) activity in experimental atherosclerosis…”
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Mechanism of uptake and retention of F-18 BMS-747158-02 in cardiomyocytes: A novel PET myocardial imaging agent by Yalamanchili, Padmaja, Wexler, Eric, Hayes, Megan, Yu, Ming, Bozek, Jody, Kagan, Mikhail, Radeke, Heike S., Azure, Michael, Purohit, Ajay, Casebier, David S., Robinson, Simon P.

“…BMS-747158-02 is a novel fluorine 18–labeled pyridazinone derivative designed for cardiac imaging. The uptake and retention mechanisms of F-18 BMS-747158-02 in…”
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Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling by HAILI SU, SPINALE, Francis G, HU, Xiao-Yu, AZURE, Michael, YALAMANCHILI, Padmaja, LIU, Richard, CHEESMAN, Edward H, ROBINSON, Simon, EDWARDS, D. Scott, SINUSAS, Albert J, DOBRUCKI, Lawrence W, SONG, James, JING HUA, SWETERLITSCH, Sarah, DIONE, Donald P, CAVALIERE, Patti, CHOW, Conroy, BOURKE, Brian N

“…Time-dependent activation of matrix metalloproteinases (MMPs) after myocardial infarction (MI) contributes to adverse left ventricular (LV) remodeling;…”
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Folding and Function of I Domain-deleted Mac-1 and Lymphocyte Function-associated Antigen-1 by Yalamanchili, Padmaja, Lu, Chafen, Oxvig, Claus, Springer, Timothy A.

“…In those integrins that contain it, the I domain is a major ligand recognition site. The I domain is inserted between β-sheets 2 and 3 of the predicted…”
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Synthesis and Biological Evaluation of the Mitochondrial Complex 1 Inhibitor 2-[4-(4-Fluorobutyl)benzylsulfanyl]-3-methylchromene-4-one as a Potential Cardiac Positron Emission Tomography Tracer by Radeke, Heike, Hanson, Kelley, Yalamanchili, Padmaja, Hayes, Megan, Zhang, Zhi-Qin, Azure, Michael, Yu, Ming, Guaraldi, Mary, Kagan, Mikhail, Robinson, Simon, Casebier, David

“…A series of fluorinated chromone analogs with IC50 values ranging from 9 to 133 nM for the mitochondrial complex 1 (MC-I) has been prepared. A…”
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Definition of EGF-like, Closely Interacting Modules That Bear Activation Epitopes in Integrin β Subunits by Takagi, Junichi, Beglova, Natalia, Yalamanchili, Padmaja, Blacklow, Stephen C., Springer, Timothy A.

“…Integrin β subunits contain four cysteine-rich repeats in a long extracellular stalk that connects the headpiece to the membrane. Most mAbs to integrin…”
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Assessment of 18F-labeled mitochondrial complex I inhibitors as PET myocardial perfusion imaging agents in rats, rabbits, and primates by Yu, Ming, Guaraldi, Mary, Kagan, Mikhail, Mistry, Mahesh, McDonald, Jennifer, Bozek, Jody, Yalamanchili, Padmaja, Hayes, Megan, Azure, Michael, Purohit, Ajay, Radeke, Heike, Casebier, David S., Robinson, Simon P.

“…Purpose Myocardial extractions of mitochondria complex I (MC-I) inhibitors were high and well correlated with flow. This study assessed the potential of MC-I…”
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AAV2-hAADC (Eladocagene Exuparvovec) Biodistribution and Expression: Superiority of Intraputaminal versus Intracerebroventricular and Intrathecal (Lumbar) Routes of Administration by Compton, David R, DeMarco, Steven J, Yalamanchili, Padmaja

“…Aromatic L-amino acid decarboxylase deficiency is a genetic disorder of enzyme loss with decreased neurotransmitter synthesis, and it is characterized by…”
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Molecular Imaging of Matrix Metalloproteinase in Atherosclerotic Lesions : Resolution With Dietary Modification and Statin Therapy by FUJIMOTO, Shinichiro, HARTUNG, Dagmar, BOERSMA, Hendricus, WONG, Nathan, YAMAZAKI, Junichi, NARULA, Navneet, PETROV, Artiom, NARULA, Jagat, OHSHIMA, Satoru, EDWARDS, D. Scott, JUN ZHOU, YALAMANCHILI, Padmaja, AZURE, Michael, FUJIMOTO, Ai, ISOBE, Satoshi, MATSUMOTO, Yuji

“…This study sought to evaluate the feasibility of noninvasive detection of matrix metalloproteinase (MMP) activity in experimental atherosclerosis using…”
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Effect of LX4211 on glucose homeostasis and body composition in preclinical models by Powell, David R, DaCosta, Christopher M, Smith, Melinda, Doree, Deon, Harris, Angela, Buhring, Lindsey, Heydorn, William, Nouraldeen, Amr, Xiong, Wendy, Yalamanchili, Padmaja, Mseeh, Faika, Wilson, Alan, Shadoan, Melanie, Zambrowicz, Brian, Ding, Zhi-Ming

“…Treatments that lower blood glucose levels and body weight should benefit patients with type 2 diabetes mellitus (T2DM). We developed LX4211…”
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Cleavage of Transcriptional Activator Oct-1 by Poliovirus Encoded Protease 3Cpro by Yalamanchili, Padmaja, Weidman, Kathy, Dasgupta, Asim

“…In HeLa cells, RNA polymerase II mediated transcription is severely inhibited by poliovirus infection. Both basal and activated transcription are affected to…”
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Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932) by Bagdanoff, Jeffrey T, Donoviel, Michael S, Nouraldeen, Amr, Carlsen, Marianne, Jessop, Theodore C, Tarver, James, Aleem, Saadat, Dong, Li, Zhang, Haiming, Boteju, Lakmal, Hazelwood, Jill, Yan, Jack, Bednarz, Mark, Layek, Suman, Owusu, Iris B, Gopinathan, Suma, Moran, Liam, Lai, Zhong, Kramer, Jeff, Kimball, S. David, Yalamanchili, Padmaja, Heydorn, William E, Frazier, Kenny S, Brooks, Barbara, Brown, Philip, Wilson, Alan, Sonnenburg, William K, Main, Alan, Carson, Kenneth G, Oravecz, Tamas, Augeri, David J

“…Sphingosine 1-phosphate lyase (S1PL) has been characterized as a novel target for the treatment of autoimmune disorders using genetic and pharmacological…”
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Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of ( E )-1-(4-((1 R ,2 S ,3 R )-1,2,3,4-Tetrahydroxybutyl)-1 H -imidazol-2-yl)ethanone Oxime (LX2931) and (1 R ,2 S ,3 R )-1-(2-(Isoxazol-3-yl)-1 H -imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932) by Bagdanoff, Jeffrey T., Donoviel, Michael S., Nouraldeen, Amr, Carlsen, Marianne, Jessop, Theodore C., Tarver, James, Aleem, Saadat, Dong, Li, Zhang, Haiming, Boteju, Lakmal, Hazelwood, Jill, Yan, Jack, Bednarz, Mark, Layek, Suman, Owusu, Iris B., Gopinathan, Suma, Moran, Liam, Lai, Zhong, Kramer, Jeff, Kimball, S. David, Yalamanchili, Padmaja, Heydorn, William E., Frazier, Kenny S., Brooks, Barbara, Brown, Philip, Wilson, Alan, Sonnenburg, William K., Main, Alan, Carson, Kenneth G., Oravecz, Tamas, Augeri, David J.

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Amino Acid Derived Enamides:  Synthesis and Aminopeptidase Activity by Cesati, Richard R, Dwyer, Greg, Jones, Reinaldo C, Hayes, Megan P, Yalamanchili, Padmaja, Casebier, David S

“…Recently developed copper-catalyzed coupling methodology has been applied to the synthesis of amino acid derived enamides. Bond formation proved to be strongly…”
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Synthesis and Biological Evaluation of Pyridazinone Analogues as Potential Cardiac Positron Emission Tomography Tracers by Purohit, Ajay, Radeke, Heike, Azure, Michael, Hanson, Kelley, Benetti, Richard, Su, Fran, Yalamanchili, Padmaja, Yu, Ming, Hayes, Megan, Guaraldi, Mary, Kagan, Mikhail, Robinson, Simon, Casebier, David

“…A series of fluorinated pyridazinone derivatives with IC50 values ranging from 8 to 4000 nM for the mitochondrial complex 1 (MC1) have been prepared…”
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Tu1333 Lx1033, a Second Generation Locally-Acting Serotonin Synthesis Inhibitor Demonstrates Increased Potency and Favorable Safety Profile in Preclinical Studies by Yang, Qi M, Yu, Wangsheng, Swaffield, Jonathan, Powell, David, Wilson, Alan G, Brommage, Robert, Yalamanchili, Padmaja, Heydorn, William, Main, Alan J, Zambrowicz, Brian

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Evaluation of LMI1195, a Novel 18 F-Labeled Cardiac Neuronal PET Imaging Agent, in Cells and Animal Models by Yu, Ming, Bozek, Jody, Lamoy, Melanie, Guaraldi, Mary, Silva, Paula, Kagan, Mikhail, Yalamanchili, Padmaja, Onthank, David, Mistry, Mahesh, Lazewatsky, Joel, Broekema, Matthias, Radeke, Heike, Purohit, Ajay, Cdebaca, Michael, Azure, Michael, Cesati, Richard, Casebier, David, Robinson, Simon P.

“…Background— Heart failure has been associated with impaired cardiac sympathetic neuronal function. Cardiac imaging with radiolabeled agents that are substrates…”
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Evaluation of LMI1195, a Novel 18F-Labeled Cardiac Neuronal PET Imaging Agent, in Cells and Animal Models by MING YU, BOZEK, Jody, BROEKEMA, Matthias, RADEKE, Heike, PUROHIT, Ajay, CDEBACA, Michael, AZURE, Michael, CESATI, Richard, CASEBIER, David, ROBINSON, Simon P, LAMOY, Melanie, GUARALDI, Mary, SILVA, Paula, KAGAN, Mikhail, YALAMANCHILI, Padmaja, ONTHANK, David, MISTRY, Mahesh, LAZEWATSKY, Joel

“…Heart failure has been associated with impaired cardiac sympathetic neuronal function. Cardiac imaging with radiolabeled agents that are substrates for the…”
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Radiolabeled Divalent Peptidomimetic Vitronectin Receptor Antagonists as Potential Tumor Radiotherapeutic and Imaging Agents by Harris, Thomas D, Cheesman, Edward, Harris, Anthony R, Sachleben, Richard, Edwards, D. Scott, Liu, Shuang, Bartis, Judit, Ellars, Charles, Onthank, Dave, Yalamanchili, Padmaja, Heminway, Stuart, Silva, Paula, Robinson, Simon, Lazewatsky, Joel, Rajopadhye, Milind, Barrett, John

“…The integrin receptor αvβ3 is overexpressed on the endothelial cells of growing tumors and on some tumor cells themselves. A radiolabeled αvβ3 antagonists…”
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Poliovirus 3C Protease-Mediated Degradation of Transcriptional Activator p53 Requires a Cellular Activity by Weidman, Mary K., Yalamanchili, Padmaja, Ng, Bryant, Tsai, Weimin, Dasgupta, Asim

“…Infection of HeLa cells with poliovirus leads to rapid shut-off of host cell transcription by RNA polymerase II. Previous results have suggested that both the…”
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