Search Results - "Yakunin, Alexander F"

Heavy Metal Removal by Bioaccumulation Using Genetically Engineered Microorganisms by Diep, Patrick, Mahadevan, Radhakrishnan, Yakunin, Alexander F

“…Wastewater effluents from mines and metal refineries are often contaminated with heavy metal ions, so they pose hazards to human and environmental health…”
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One-Pot Biocatalytic Transformation of Adipic Acid to 6‑Aminocaproic Acid and 1,6-Hexamethylenediamine Using Carboxylic Acid Reductases and Transaminases by Fedorchuk, Tatiana P, Khusnutdinova, Anna N, Evdokimova, Elena, Flick, Robert, Di Leo, Rosa, Stogios, Peter, Savchenko, Alexei, Yakunin, Alexander F

“…Production of platform chemicals from renewable feedstocks is becoming increasingly important due to concerns on environmental contamination, climate change,…”
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Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutières Syndrome and HIV-1 Restriction by Beloglazova, Natalia, Flick, Robert, Tchigvintsev, Anatoli, Brown, Greg, Popovic, Ana, Nocek, Boguslaw, Yakunin, Alexander F.

“…The human HD domain protein SAMHD1 is implicated in the Aicardi-Goutières autoimmune syndrome and in the restriction of HIV-1 replication in myeloid cells…”
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Biosynthesis and Activity of Prenylated FMN Cofactors by Wang, Po-Hsiang, Khusnutdinova, Anna N, Luo, Fei, Xiao, Johnny, Nemr, Kayla, Flick, Robert, Brown, Greg, Mahadevan, Radhakrishnan, Edwards, Elizabeth A, Yakunin, Alexander F

“…Prenylated flavin mononucleotide (prFMN) is a recently discovered cofactor required by the UbiD family of reversible decarboxylases involved in ubiquinone…”
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CRISPR-induced DNA reorganization for multiplexed nucleic acid detection by Karlikow, Margot, Amalfitano, Evan, Yang, Xiaolong, Doucet, Jennifer, Chapman, Abigail, Mousavi, Peivand Sadat, Homme, Paige, Sutyrina, Polina, Chan, Winston, Lemak, Sofia, Yakunin, Alexander F., Dolezal, Adam G., Kelley, Shana, Foster, Leonard J., Harpur, Brock A., Pardee, Keith

“…Nucleic acid sensing powered by the sequence recognition of CRIPSR technologies has enabled major advancement toward rapid, accurate and deployable…”
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Structure and activity of the Cas3 HD nuclease MJ0384, an effector enzyme of the CRISPR interference by Beloglazova, Natalia, Petit, Pierre, Flick, Robert, Brown, Greg, Savchenko, Alexei, Yakunin, Alexander F

“…Clustered regularly interspaced short palindromic repeats (CRISPRs) and Cas proteins represent an adaptive microbial immunity system against viruses and…”
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Engineering a short, aldolase-based pathway for (R)-1,3-butanediol production in Escherichia coli by Nemr, Kayla, Müller, Jonas E.N., Joo, Jeong Chan, Gawand, Pratish, Choudhary, Ruhi, Mendonca, Burton, Lu, Shuyi, Yu, Xiuyan, Yakunin, Alexander F., Mahadevan, Radhakrishnan

“…Microbial processes can produce a wide range of compounds; however, producing complex and long chain hydrocarbons remains a challenge. Aldol condensation…”
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Harnessing extremophilic carboxylesterases for applications in polyester depolymerisation and plastic waste recycling by Williams, Gwion B, Ma, Hairong, Khusnutdinova, Anna N, Yakunin, Alexander F, Golyshin, Peter N

“…The steady growth in industrial production of synthetic plastics and their limited recycling have resulted in severe environmental pollution and contribute to…”
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Riboneogenesis in Yeast by Clasquin, Michelle F., Melamud, Eugene, Singer, Alexander, Gooding, Jessica R., Xu, Xiaohui, Dong, Aiping, Cui, Hong, Campagna, Shawn R., Savchenko, Alexei, Yakunin, Alexander F., Rabinowitz, Joshua D., Caudy, Amy A.

“…Glucose is catabolized in yeast via two fundamental routes, glycolysis and the oxidative pentose phosphate pathway, which produces NADPH and the essential…”
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Activity screening of environmental metagenomic libraries reveals novel carboxylesterase families by Popovic, Ana, Hai, Tran, Tchigvintsev, Anatoly, Hajighasemi, Mahbod, Nocek, Boguslaw, Khusnutdinova, Anna N., Brown, Greg, Glinos, Julia, Flick, Robert, Skarina, Tatiana, Chernikova, Tatyana N., Yim, Veronica, Brüls, Thomas, Paslier, Denis Le, Yakimov, Michail M., Joachimiak, Andrzej, Ferrer, Manuel, Golyshina, Olga V., Savchenko, Alexei, Golyshin, Peter N., Yakunin, Alexander F.

“…Metagenomics has made accessible an enormous reserve of global biochemical diversity. To tap into this vast resource of novel enzymes, we have screened over…”
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Automation assisted anaerobic phenotyping for metabolic engineering by Raj, Kaushik, Venayak, Naveen, Diep, Patrick, Golla, Sai Akhil, Yakunin, Alexander F, Mahadevan, Radhakrishnan

“…Microorganisms can be metabolically engineered to produce a wide range of commercially important chemicals. Advancements in computational strategies for strain…”
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Systematic Genetic Screens Reveal the Dynamic Global Functional Organization of the Bacterial Translation Machinery by Gagarinova, Alla, Stewart, Geordie, Samanfar, Bahram, Phanse, Sadhna, White, Carl A., Aoki, Hiroyuki, Deineko, Viktor, Beloglazova, Natalia, Yakunin, Alexander F., Golshani, Ashkan, Brown, Eric D., Babu, Mohan, Emili, Andrew

“…Bacterial protein synthesis is an essential, conserved, and environmentally responsive process. Yet, many of its components and dependencies remain…”
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Biocatalytic production of adipic acid from glucose using engineered Saccharomyces cerevisiae by Raj, Kaushik, Partow, Siavash, Correia, Kevin, Khusnutdinova, Anna N., Yakunin, Alexander F., Mahadevan, Radhakrishnan

“…Adipic acid is an important industrial chemical used in the synthesis of nylon-6,6. The commercial synthesis of adipic acid uses petroleum-derived benzene and…”
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Biocatalytic in Vitro and in Vivo FMN Prenylation and (De)carboxylase Activation by Batyrova, Khorcheska A, Khusnutdinova, Anna N, Wang, Po-Hsiang, Di Leo, Rosa, Flick, Robert, Edwards, Elizabeth A, Savchenko, Alexei, Yakunin, Alexander F

“…Reversible UbiD-like (de)­carboxylases represent a large family of mostly uncharacterized enzymes, which require the recently discovered prenylated FMN (prFMN)…”
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A Novel Family of Sequence-specific Endoribonucleases Associated with the Clustered Regularly Interspaced Short Palindromic Repeats by Beloglazova, Natalia, Brown, Greg, Zimmerman, Matthew D., Proudfoot, Michael, Makarova, Kira S., Kudritska, Marina, Kochinyan, Samvel, Wang, Shuren, Chruszcz, Maksymilian, Minor, Wladek, Koonin, Eugene V., Edwards, Aled M., Savchenko, Alexei, Yakunin, Alexander F.

“…Clustered regularly interspaced short palindromic repeats (CRISPRs) together with the associated CAS proteins protect microbial cells from invasion by foreign…”
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Toroidal Structure and DNA Cleavage by the CRISPR-Associated [4Fe-4S] Cluster Containing Cas4 Nuclease SSO0001 from Sulfolobus solfataricus by Lemak, Sofia, Beloglazova, Natalia, Nocek, Boguslaw, Skarina, Tatiana, Flick, Robert, Brown, Greg, Popovic, Ana, Joachimiak, Andrzej, Savchenko, Alexei, Yakunin, Alexander F

“…Cas4 proteins, a core protein family associated with the microbial system of adaptive immunity CRISPR, are predicted to function in the adaptation step of the…”
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Engineered nickel bioaccumulation in Escherichia coli by NikABCDE transporter and metallothionein overexpression by Diep, Patrick, Leo Shen, Heping, Wiesner, Julian A., Mykytczuk, Nadia, Papangelakis, Vladimiros, Yakunin, Alexander F., Mahadevan, Radhakrishnan

“…Mine wastewater often contains dissolved metals at concentrations too low to be economically extracted by existing technologies, yet too high for environmental…”
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Evaluating the effect of enzymatic pretreatment on the anaerobic digestibility of pulp and paper biosludge by Bonilla, Sofia, Choolaei, Zahra, Meyer, Torsten, Edwards, Elizabeth A., Yakunin, Alexander F., Allen, D. Grant

“…[Display omitted] •A new and rigorous approach for assessing the effect of enzymatic pretreatment on AD is proposed.•Enzymes can improve anaerobic digestion…”
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Structure-based mutational studies of substrate inhibition of betaine aldehyde dehydrogenase BetB from Staphylococcus aureus by Chen, Chao, Joo, Jeong Chan, Brown, Greg, Stolnikova, Ekaterina, Halavaty, Andrei S, Savchenko, Alexei, Anderson, Wayne F, Yakunin, Alexander F

“…Inhibition of enzyme activity by high concentrations of substrate and/or cofactor is a general phenomenon demonstrated in many enzymes, including aldehyde…”
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Conditional Epistatic Interaction Maps Reveal Global Functional Rewiring of Genome Integrity Pathways in Escherichia coli by Kumar, Ashwani, Beloglazova, Natalia, Bundalovic-Torma, Cedoljub, Phanse, Sadhna, Deineko, Viktor, Gagarinova, Alla, Musso, Gabriel, Vlasblom, James, Lemak, Sofia, Hooshyar, Mohsen, Minic, Zoran, Wagih, Omar, Mosca, Roberto, Aloy, Patrick, Golshani, Ashkan, Parkinson, John, Emili, Andrew, Yakunin, Alexander F., Babu, Mohan

“…As antibiotic resistance is increasingly becoming a public health concern, an improved understanding of the bacterial DNA damage response (DDR), which is…”
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