Search Results - "Yako, Tomohiro"

Lipid Droplet Accumulation Promotes RPE Dysfunction by Yako, Tomohiro, Otsu, Wataru, Nakamura, Shinsuke, Shimazawa, Masamitsu, Hara, Hideaki

“…Non-exudative age-related macular degeneration (AMD) is an irreversibly progressive retinal degenerative disease characterized by dysfunction and loss of…”
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Free-Radical Scavenger NSP-116 Protects the Corneal Epithelium against UV-A and Blue LED Light Exposure by Ishida, Kodai, Yako, Tomohiro, Tanaka, Miruto, Otsu, Wataru, Nakamura, Shinsuke, Shimazawa, Masamitsu, Tsusaki, Hideshi, Hara, Hideaki

“…The corneal epithelium is continuously exposed to oxygen, light, and environmental substances. Excessive exposure to those stresses is thought to be a risk…”
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Pharmacological inhibition of mitochondrial fission attenuates oxidative stress-induced damage of retinal pigmented epithelial cells by Yako, Tomohiro, Nakamura, Maho, Nakamura, Shinsuke, Hara, Hideaki, Shimazawa, Masamitsu

“…Mitochondria maintain their function by the process of mitochondrial dynamics, which involves repeated fusion and fission. It is thought that the failure of…”
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Reduced mitochondrial complex II activity enhances cell death via intracellular reactive oxygen species in STHdhQ111 striatal neurons with mutant huntingtin by Okada, Noria, Yako, Tomohiro, Nakamura, Shinsuke, Shimazawa, Masamitsu, Hara, Hideaki

“…Huntington's disease (HD) is an inherited neurodegenerative disorder caused by CAG repeat expansion in the huntingtin (HTT) gene. Here, we examined the effects…”
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Mitochondria dynamics in the aged mice eye and the role in the RPE phagocytosis by Yako, Tomohiro, Nakamura, Maho, Otsu, Wataru, Nakamura, Shinsuke, Shimazawa, Masamitsu, Hara, Hideaki

“…Aging is a predominant risk factor for various eye diseases. Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, and its…”
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A triterpenoid Nrf2 activator, RS9, promotes LC3-associated phagocytosis of photoreceptor outer segments in a p62-independent manner by Saito, Yuichi, Yako, Tomohiro, Otsu, Wataru, Nakamura, Shinsuke, Inoue, Yuki, Muramatsu, Aomi, Nakagami, Yasuhiro, Shimazawa, Masamitsu, Hara, Hideaki

“…Daily phagocytosis of shed photoreceptor outer segments (POS) by the retinal pigment epithelium (RPE) is required to sustain the visual function. Recent…”
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Crocetin protects against mitochondrial damage induced by UV-A irradiation in corneal epithelial cell line HCE-T cells by Otsu, Wataru, Yako, Tomohiro, Sugisawa, Emi, Nakamura, Shinsuke, Tsusaki, Hideshi, Umigai, Naofumi, Shimazawa, Masamitsu, Hara, Hideaki

“…The corneal epithelium is located at the outermost layer of the ocular surface and continuously exposed to environmental factors, such as ultraviolet (UV)…”
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Retinal damage alters gene expression profile in lacrimal glands of mice by Ohno, Yuta, Yako, Tomohiro, Satoh, Keitaro, Nagase, Haruna, Shitara, Akiko, Hara, Hideaki, Kashimata, Masanori

“…Early detection of such retinal diseases as glaucoma and age-related macular degeneration (AMD) is important to prevent blindness. There have been reports of…”
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Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma by Tsuji, Shohei, Nakamura, Shinsuke, Maoka, Takashi, Yamada, Tetsuya, Imai, Takahiko, Ohba, Takuya, Yako, Tomohiro, Hayashi, Masahiro, Endo, Ken, Saio, Masanao, Hara, Hideaki, Shimazawa, Masamitsu

“…Several antitumour drugs have been isolated from natural products and many clinical trials are underway to evaluate their potential. There have been numerous…”
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Exposure to excessive blue LED light damages retinal pigment epithelium and photoreceptors of pigmented mice by Nakamura, Maho, Yako, Tomohiro, Kuse, Yoshiki, Inoue, Yuki, Nishinaka, Anri, Nakamura, Shinsuke, Shimazawa, Masamitsu, Hara, Hideaki

“…To determine the characteristics of the damages of the retinal pigment epithelium (RPE) and photoreceptors of pigmented mice induced by exposure to blue light…”
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Bilberry extract and anthocyanins suppress unfolded protein response induced by exposure to blue LED light of cells in photoreceptor cell line by Ooe, Emi, Kuse, Yoshiki, Yako, Tomohiro, Sogon, Tetsuya, Nakamura, Shinsuke, Hara, Hideaki, Shimazawa, Masamitsu

“…The purpose of this study was to investigate the effects of bilberry extract with its anthocyanins on retinal photoreceptor cell damage and on the endoplasmic…”
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