Search Results - "Yakhini, Z"
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Molecular classification of cutaneous malignant melanoma by gene expression profiling
Published in Nature (London) (03-08-2000)“…The most common human cancers are malignant neoplasms of the skin. Incidence of cutaneous melanoma is rising especially steeply, with minimal progress in…”
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Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression
Published in Oncogene (25-10-2012)“…Once stimulated, the epidermal growth factor receptor (EGFR) undergoes self-phosphorylation, which, on the one hand, instigates signaling cascades, and on the…”
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Chromosomal aberrations and gene expression profiles in non-small cell lung cancer
Published in Lung cancer (Amsterdam, Netherlands) (01-05-2007)“…Summary Alterations in genomic content and changes in gene expression levels are central characteristics of tumors and pivotal to the tumorigenic process. We…”
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Tissue classification with gene expression profiles
Published in Journal of computational biology (01-01-2000)“…Constantly improving gene expression profiling technologies are expected to provide understanding and insight into cancer-related cellular processes. Gene…”
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SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance
Published in The pharmacogenomics journal (01-12-2010)“…The dose of docetaxel is currently calculated based on body surface area and does not reflect the pharmacokinetic, metabolic potential or genetic background of…”
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steroid metabolomic approach to 17α-hydroxylase/17,20 lyase deficiency
Published in Metabolomics (01-09-2010)“…The CYP17A1 gene encodes 17OHase and 17,20-lyase activities. We have previously reported an E305G mutation in CYP17A1 that was found by expression studies to…”
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Universal DNA tag systems: a combinatorial design scheme
Published in Journal of computational biology (01-01-2000)“…Custom-designed DNA arrays offer the possibility of simultaneously monitoring thousands of hybridization reactions. These arrays show great potential for many…”
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The Fine-Scale and Complex Architecture of Human Copy-Number Variation
Published in American journal of human genetics (01-03-2008)“…Despite considerable excitement over the potential functional significance of copy-number variants (CNVs), we still lack knowledge of the fine-scale…”
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Clustering gene expression patterns
Published in Journal of computational biology (1999)“…Recent advances in biotechnology allow researchers to measure expression levels for thousands of genes simultaneously, across different conditions and over…”
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Discovering local structure in gene expression data: the order-preserving submatrix problem
Published in Journal of computational biology (01-01-2003)“…This paper concerns the discovery of patterns in gene expression matrices, in which each element gives the expression level of a given gene in a given…”
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Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer
Published in Nature communications (2013)“…About one-third of oestrogen receptor alpha-positive breast cancer patients treated with tamoxifen relapse. Here we identify the nuclear receptor retinoic acid…”
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Comparative Genomic Hybridization Using Oligonucleotide Microarrays and Total Genomic DNA
Published in Proceedings of the National Academy of Sciences - PNAS (21-12-2004)“…Array-based comparative genomic hybridization (CGH) measures copy-number variations at multiple loci simultaneously, providing an important tool for studying…”
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Gene-Expression Profiles in Hereditary Breast Cancer
Published in The New England journal of medicine (22-02-2001)“…Inheritance of a mutant BRCA1 or BRCA2 gene (numbers 113705 and 600185, respectively, in Online Mendelian Inheritance in Man, a catalogue of inherited…”
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Gene Expression Analysis Reveals Matrilysin as a Key Regulator of Pulmonary Fibrosis in Mice and Humans
Published in Proceedings of the National Academy of Sciences - PNAS (30-04-2002)“…Pulmonary fibrosis is a progressive and largely untreatable group of disorders that affects up to 100,000 people on any given day in the United States. To…”
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Efficient calculation of interval scores for DNA copy number data analysis
Published in Journal of computational biology (01-03-2006)“…DNA amplifications and deletions characterize cancer genome and are often related to disease evolution. Microarray-based techniques for measuring these DNA…”
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Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction
Published in Circulation (New York, N.Y.) (23-09-2003)“…Apelin is among the most potent stimulators of cardiac contractility known. However, no physiological or pathological role for apelin-angiotensin receptor-like…”
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Molecular Classification of Familial Non-BRCA1/BRCA2 Breast Cancer
Published in Proceedings of the National Academy of Sciences - PNAS (04-03-2003)“…In the decade since their discovery, the two major breast cancer susceptibility genes BRCA1 and BRCA2, have been shown conclusively to be involved in a…”
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Pathway analysis of coronary atherosclerosis
Published in Physiological genomics (21-09-2005)“…1 Donald W. Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University, Stanford;…”
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