Search Results - "Yager, Kraig"

Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2 by Nie, Zhe, Perretta, Carin, Erickson, Philip, Margosiak, Stephen, Almassy, Robert, Lu, Jia, Averill, April, Yager, Kraig M., Chu, Shaosong

“…Structure-guided modifications to a series of pyrazolo[1,5-a][1,3,5]triazine derivatives provided pM inhibitors of protein kinase CK2 with low μM cytotoxic…”
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Discovery of (2S)‑1-[4-(2-{6-Amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]‑9H‑purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a Purine-Based Hsp90 Inhibitor by Kim, Se-Ho, Bajji, Ashok, Tangallapally, Rajendra, Markovitz, Benjamin, Trovato, Richard, Shenderovich, Mark, Baichwal, Vijay, Bartel, Paul, Cimbora, Daniel, McKinnon, Rena, Robinson, Rosann, Papac, Damon, Wettstein, Daniel, Carlson, Robert, Yager, Kraig M

“…Modulation of Hsp90 (heat shock protein 90) function has been recognized as an attractive approach for cancer treatment, since many cancer cells depend on…”
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Novel Mps1 kinase inhibitors: From purine to pyrrolopyrimidine and quinazoline leads by Bursavich, Matthew G., Dastrup, David, Shenderovich, Mark, Yager, Kraig M., Cimbora, Daniel M., Williams, Brandi, Kumar, D. Vijay

“…Mps1, also known as TTK, is a mitotic checkpoint protein kinase that has become a promising new target of cancer research. In an effort to improve the…”
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Cost‐Utility of a Prognostic Test Guiding Adjuvant Chemotherapy Decisions in Early‐Stage Non‐Small Cell Lung Cancer by Stenehjem, David D., Bellows, Brandon K., Yager, Kraig M., Jones, Joshua, Kaldate, Rajesh, Siebert, Uwe, Brixner, Diana I.

“…Background. A prognostic test was developed to guide adjuvant chemotherapy (ACT) decisions in early‐stage non‐small cell lung cancer (NSCLC) adenocarcinomas…”
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Discovery of an l-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100 by Kim, Se-Ho, Tangallapally, Rajendra, Kim, In Chul, Trovato, Richard, Parker, Daniel, Patton, J. Scott, Reeves, Leslie, Bradford, Chad, Wettstein, Daniel, Baichwal, Vijay, Papac, Damon, Bajji, Ashok, Carlson, Robert, Yager, Kraig M.

“…[Display omitted] Various types of Hsp90 inhibitors have been and continue to undergo clinical investigation. One development candidate is the purine-based,…”
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Structure-Based Design, Synthesis, and Antimicrobial Activity of Indazole-Derived SAH/MTA Nucleosidase Inhibitors by Li, Xiaoming, Chu, Sam, Feher, Victoria A, Khalili, Mitra, Nie, Zhe, Margosiak, Stephen, Nikulin, Victor, Levin, James, Sprankle, Kelly G, Tedder, Martina E, Almassy, Robert, Appelt, Krzysztof, Yager, Kraig M

“…The structure-based design, synthesis, and biological activity of a novel indazole-containing inhibitor series for S-adenosyl homocysteine/methylthioadenosine…”
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Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors by Vijay Kumar, D., Hoarau, Christophe, Bursavich, Matthew, Slattum, Paul, Gerrish, David, Yager, Kraig, Saunders, Michael, Shenderovich, Mark, Roth, Bruce L., McKinnon, Rena, Chan, Ashley, Cimbora, Daniel M., Bradford, Chad, Reeves, Leslie, Patton, Scott, Papac, Damon I., Williams, Brandi L., Carlson, Robert O.

“…Efforts to optimize biological activity, novelty, selectivity and oral bioavailability of Mps1 inhibitors, from a purine based lead MPI-0479605, are described…”
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Structure-Based Design, Synthesis, and Study of Potent Inhibitors of β-Ketoacyl-acyl Carrier Protein Synthase III as Potential Antimicrobial Agents by Nie, Zhe, Perretta, Carin, Lu, Jia, Su, Ying, Margosiak, Stephen, Gajiwala, Ketan S, Cortez, Joseph, Nikulin, Victor, Yager, Kraig M, Appelt, Krzysztof, Chu, Shaosong

“…Fatty acid biosynthesis is essential for bacterial survival. Components of this biosynthetic pathway have been identified as attractive targets for the…”
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Enantioselective Synthesis of Diverse .alpha.-Amino Phosphonate Diesters by Smith, Amos B, Yager, Kraig M, Taylor, Carol M

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Triterpene based compounds with potent anti-maturation activity against HIV-1 by Gerrish, David, Kim, In Chul, Kumar, Dange V., Austin, Harry, Garrus, Jennifer E., Baichwal, Vijay, Saunders, Michael, McKinnon, Rena S., Anderson, Mark B., Carlson, Robert, Arranz-Plaza, Esther, Yager, Kraig M.

“…Efforts towards developing orally bioavailable HIV-1 maturation inhibitors starting from betulinic acid 1 are described. SAR resulted in improved potency,…”
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Peptide Synthesis Catalyzed by an Antibody Containing a Binding Site for Variable Amino Acids by Hirschmann, Ralph, Smith, Amos B., Taylor, Carol M., Benkovic, Patricia A., Taylor, Scott D., Yager, Kraig M., Sprengeler, Paul A., Benkovic, Stephen J.

“…Monoclonal antibodies, induced with a phosphonate diester hapten, catalyzed the coupling of p-nitrophenyl esters of N-acetyl valine, leucine, and phenylalanine…”
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Asymmetric Synthesis of .alpha.-Aminophosphonates via Diastereoselective Addition of Lithium Diethyl Phosphite to Chelating Imines by Yager, Kraig M, Taylor, Carol M, Smith, Amos B

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Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors by Tedder, Martina E., Nie, Zhe, Margosiak, Stephen, Chu, Shaosong, Feher, Victoria A., Almassy, Robert, Appelt, Krzysztof, Yager, Kraig M.

“…Systematic, structure-guided modifications to a series of 6-substituted purine and deaza purine derivatives provided low nM inhibitors of the bacterial enzyme…”
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Synthetic Studies of the Pyrroloquinoline Nucleus of the Makaluvamine Alkaloids. Synthesis of the Topoisomerase II Inhibitor Makaluvamine D by White, James D, Yager, Kraig M, Yakura, Takayuki

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Investigations of an Antibody Ligase by Smithrud, David B, Benkovic, Patricia A, Benkovic, Stephen J, Taylor, Carol M, Yager, Kraig M, Witherington, Jason, Philips, Barton W, Sprengeler, Paul A, Smith, Amos B, Hirschmann, Ralph

“…Further investigation of the monoclonal antibody 16G3 has revealed that it not only couples activated amino acids to form dipeptides with high turnover rates…”
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Discovery of (2 S )-1-[4-(2-{6-Amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9 H -purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a Purine-Based Hsp90 Inhibitor by Kim, Se-Ho, Bajji, Ashok, Tangallapally, Rajendra, Markovitz, Benjamin, Trovato, Richard, Shenderovich, Mark, Baichwal, Vijay, Bartel, Paul, Cimbora, Daniel, McKinnon, Rena, Robinson, Rosann, Papac, Damon, Wettstein, Daniel, Carlson, Robert, Yager, Kraig M.

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Phosphonyltriethylammonium Salts: Novel Reactive Species for the Synthesis of Phosphonate Esters and Phosphonamides by Hirschmann, Ralph, Yager, Kraig M, Taylor, Carol M, Moore, William, Sprengeler, Paul A, Witherington, Jason, Phillips, Barton W, Smith, Amos B.. III

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Phosphonate Diester and Phosphonamide Synthesis. Reaction Coordinate Analysis by 31P NMR Spectroscopy:  Identification of Pyrophosphonate Anhydrides and Highly Reactive Phosphonylammonium Salts1 by Hirschmann, Ralph, Yager, Kraig M, Taylor, Carol M, Witherington, Jason, Sprengeler, Paul A, Phillips, Barton W, Moore, William, Smith, Amos B

“…A series of phosphonochloridates was prepared from the corresponding phosphonate monoesters, and their reactions with alcohols, amines, and the bisnucleophile…”
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Validation of a cell cycle progression score for 5-year mortality risk in patients with stage I non-small cell lung cancer by Eguchi, Takashi, Kyuichi, Kadota, Evans, Brent, Sima, Camelia S., Davis, Thaylon, Hamilton, Stephanie A., Yager, Kraig, Kolquist, Kathryn A., Jones, Joshua Timothy, Hartman, Anne-Renee, Adusumili, Prasad S.

“…Abstract only…”
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Cell cycle progression score is a marker for five-year lung cancer-specific mortality risk in patients with resected stage I lung adenocarcinoma by Eguchi, Takashi, Kadota, Kyuichi, Chaft, Jamie, Evans, Brent, Kidd, John, Tan, Kay See, Dycoco, Joe, Kolquist, Kathryn, Davis, Thaylon, Hamilton, Stephanie A, Yager, Kraig, Jones, Joshua T, Travis, William D, Jones, David R, Hartman, Anne-Renee, Adusumilli, Prasad S

“…The goals of our study were (a) to validate a molecular expression signature (cell cycle progression [CCP] score and molecular prognostic score [mPS;…”
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